BocTyr(OBoc)OiPr | 663935-35-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: BocTyr(OBoc)OiPr
• 英文别名: Boc-Tyr(Boc)-OiPr；propan-2-yl (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-[4-[(2-methylpropan-2-yl)oxycarbonyloxy]phenyl]propanoate
• CAS: 663935-35-1
• 化学式: C₂₂H₃₃NO₇
• 分子量: 423.507
• InChiKey: CWNUDJXPHTWDMO-KRWDZBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  30
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  BocTyr(OBoc)OiPr 在 哌啶 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以85%的产率得到N-tert-butoxycarbonyl-L-tyrosine isopropyl ester
  参考文献：
  名称：

  Base-labile tert-butoxycarbonyl (Boc) group on phenols

  摘要：

  Phenols are deprotected with weak bases from their tert-butoxycarbonyl (Boc) derivatives. Boc deprotection with bases can avoid side reactions during the deprotection with acids. We note the lability of the Boc to bases and are able to utilize it as a new cleavage condition for synthetic studies. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.11.008
• 作为产物：
  描述：

  Boc-L-酪氨酸 在 4-二甲氨基吡啶 、 TEA 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 生成 BocTyr(OBoc)OiPr
  参考文献：
  名称：

  Base-labile tert-butoxycarbonyl (Boc) group on phenols

  摘要：

  Phenols are deprotected with weak bases from their tert-butoxycarbonyl (Boc) derivatives. Boc deprotection with bases can avoid side reactions during the deprotection with acids. We note the lability of the Boc to bases and are able to utilize it as a new cleavage condition for synthetic studies. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.11.008

文献信息

• Base-labile tert-butoxycarbonyl (Boc) group on phenols
  作者：Kozo Nakamura、Takero Nakajima、Hiroshi Kayahara、Eisaku Nomura、Hisaji Taniguchi

  DOI：10.1016/j.tetlet.2003.11.008

  日期：2004.1

  Phenols are deprotected with weak bases from their tert-butoxycarbonyl (Boc) derivatives. Boc deprotection with bases can avoid side reactions during the deprotection with acids. We note the lability of the Boc to bases and are able to utilize it as a new cleavage condition for synthetic studies. (C) 2003 Elsevier Ltd. All rights reserved.