2-(2-甲硫基嘧啶-4-基)丙二醛 | 77168-37-7

• 物质功能分类: 医药中间体 - 嘧啶类化合物
• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 中文名称: 2-(2-甲硫基嘧啶-4-基)丙二醛
• 中文别名: 2-[2-甲基硫代-4-嘧啶基]-丙二醛
• 英文名称: 2-(2'-methylthiopyrimidin-4'-yl)malonaldehyde
• 英文别名: 2-(2-methanesulfanylpyrimidin-4-yl)-malonaldehyde；2-(2-(Methylthio)pyrimidin-4-yl)malonaldehyde；2-(2-methylsulfanylpyrimidin-4-yl)propanedial
• CAS: 77168-37-7
• 化学式: C₈H₈N₂O₂S
• 分子量: 196.23
• InChiKey: ARQRGYFOBLEOBL-UHFFFAOYSA-N

物化性质

• 沸点：
  340.2±32.0 °C(Predicted)
• 密度：
  1.30

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  85.2
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 海关编码：
  2933599090

反应信息

• 作为反应物：
  描述：

  2-(2-甲硫基嘧啶-4-基)丙二醛 在 一水合肼 作用下， 以 甲醇 、 水 为溶剂， 以86%的产率得到2-(methylthio)-4-(1H-pyrazol-4-yl)pyrimidine
  参考文献：
  名称：

  Brown, Desmond J.; Cowden, William B.; Grigg, Geoffrey W., Australian Journal of Chemistry, 1980, vol. 33, # 10, p. 2291 - 2298

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲基-2-甲硫基嘧啶 、 N,N-二甲基甲酰胺 在 光气 作用下， 生成 2-(2-甲硫基嘧啶-4-基)丙二醛
  参考文献：
  名称：

  Brown, Desmond J.; Cowden, William B.; Grigg, Geoffrey W., Australian Journal of Chemistry, 1980, vol. 33, # 10, p. 2291 - 2298

  摘要：

  DOI：

文献信息

• Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
  申请人：——

  公开号：US20020111353A1

  公开（公告）日：2002-08-15

  The present invention provides compounds of formula I: 1 wherein G is a small group selected from hydrogen or C 1-3 alkyl, Q is pyridine or pyrimidine, and R 1 -R 3 are as defined in the specification. These compounds are selective JNK inhibitors showing good activity against the three isoforms of JNK (JNK1, JNK2 and JNK3) and relatively low activity against p38 kinase. The compounds are therefore useful for treating JNK-mediated diseases, especially neurodegenerative diseases in which all three JNK isoforms are implicated.

  本发明提供了I式化合物：1其中G是氢或C1-3烷基中的小基团，Q是吡啶或嘧啶，R1-R3如规范中所定义。这些化合物是选择性JNK抑制剂，对JNK的三个亚型（JNK1、JNK2和JNK3）表现出良好的活性，并对p38激酶的活性相对较低。因此，这些化合物可用于治疗JNK介导的疾病，特别是所有三个JNK亚型都涉及的神经退行性疾病。
• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。
• INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP1343781B1

  公开（公告）日：2008-09-03
• BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Nuevolution A/S

  公开号：EP2558577A1

  公开（公告）日：2013-02-20
• BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Gouliaev Alex Haahr

  公开号：US20130281324A1

  公开（公告）日：2013-10-24

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.