succinimidyl 3-[(4-formylphenyl)methylamino]propanoate | 1015700-99-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: succinimidyl 3-[(4-formylphenyl)methylamino]propanoate
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 3-(4-formyl-N-methylanilino)propanoate
• CAS: 1015700-99-8
• 化学式: C₁₅H₁₆N₂O₅
• 分子量: 304.302
• InChiKey: PZNGVXKCYCSQBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  84
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 N-(4-formyl-phenyl)-N-methyl-β-alanine 在 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以79%的产率得到succinimidyl 3-[(4-formylphenyl)methylamino]propanoate
  参考文献：
  名称：

  Diamine Catalyzed Hemicyanine Dye Formation from Nonfluorescent Precursors through DNA Programmed Chemistry

  摘要：

  A hemicyanine fluorescent dye was generated by a diamine-catalyzed, DNA-templated, aldol-type condensation from nonfluorescent precursors. Studies of reaction rate and yield as a function of catalyst structure indicated the diamine catalyst operates in a concerted mechanism on both reaction components. Our findings expand the scope of reactions that can be performed by DPC and demonstrate that de novo chemical synthesis of labels can be coupled to biological recognition events in a homogeneous format with essentially no background.

  DOI：

  10.1021/ja0753602

文献信息

• Biodetection by nucleic acid-templated chemistry
  申请人：Coull M. James

  公开号：US20070154899A1

  公开（公告）日：2007-07-05

  The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid templated chemistry, for example, by generating fluorescent, chemiluminescent and/or chromophoric signals.
• BIODETECTION BY NUCLEIC ACID-TEMPLATED CHEMISTRY
  申请人：Coull James M.

  公开号：US20130084561A1

  公开（公告）日：2013-04-04

  The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid templated chemistry, for example, by generating fluorescent, chemiluminescent and/or chromophoric signals.
• Diamine Catalyzed Hemicyanine Dye Formation from Nonfluorescent Precursors through DNA Programmed Chemistry
  作者：Yumei Huang、James M. Coull

  DOI：10.1021/ja0753602

  日期：2008.3.1

  A hemicyanine fluorescent dye was generated by a diamine-catalyzed, DNA-templated, aldol-type condensation from nonfluorescent precursors. Studies of reaction rate and yield as a function of catalyst structure indicated the diamine catalyst operates in a concerted mechanism on both reaction components. Our findings expand the scope of reactions that can be performed by DPC and demonstrate that de novo chemical synthesis of labels can be coupled to biological recognition events in a homogeneous format with essentially no background.