N4-甲基-4,5-嘧啶二胺 | 13784-17-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: N4-甲基-4,5-嘧啶二胺
• 中文别名: 甜菜安；N4甲基-4,5-二氨基嘧啶
• 英文名称: 5-amino-4-methylaminopyrimidine
• 英文别名: N⁴-methyl-pyrimidine-4,5-diamine；N⁴-methyl-pyrimidine-4,5-diyldiamine；N⁴-Methyl-pyrimidin-4,5-diyldiamin；4-Methylamino-5-aminopyrimidin；4,5-Pyrimidinediamine, N4-methyl-(9CI)；4-N-methylpyrimidine-4,5-diamine
• CAS: 13784-17-3
• 化学式: C₅H₈N₄
• 分子量: 124.145
• InChiKey: KLPOQSPEGNLKIY-UHFFFAOYSA-N

物化性质

• 熔点：
  207-210 °C
• 沸点：
  312.4±27.0 °C(Predicted)
• 密度：
  1.271±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  63.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2933599090

反应信息

• 作为反应物：
  描述：

  N4-甲基-4,5-嘧啶二胺 在 甲醇 、 硫酸 、 水 、 硝酸 、 sodium methylate 作用下， 生成 5,8-dimethyl-5,8-dihydro-pteridine-6,7-dione
  参考文献：
  名称：

  Albert et al., Journal of the Chemical Society, 1956, p. 2066,2070

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氯-N-甲基-5-硝基-4-氨基嘧啶 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以98%的产率得到N4-甲基-4,5-嘧啶二胺
  参考文献：
  名称：

  NOVEL CEPHALOSPORIN DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF

  摘要：

  公开号：

  EP2706062B1

文献信息

• Purine studies. Part 24. Preparation of 1,6- and 7,8-dihydro-derivatives of 8-trifluoromethylpurines by reduction
  作者：Adrien Albert

  DOI：10.1039/p19810002974

  日期：——

  (1a) was converted by catalytic hydrogentation entirely to the 1,6-dihydro-derivative (3a), whereas 9-methyl-8-trifluoromethypurine (1b) produced a 2 : 1 mixture of the 1,6-(3b) and 7,8-(5) dihydroderivatives. The new hydrogenated purines are characterised by unusual stability. Physical properties are discussed and compared with those of analogues from several other heterocyclic series.

  通过催化加氢将8-三氟甲基嘌呤（1a）完全转化为1,6-二氢衍生物（3a），而9-甲基-8-三氟甲基嘌呤（1b）则生成了1：6-（3b）的2：1混合物）和7,8-（5）二氢衍生物。新的氢化嘌呤具有非同寻常的稳定性。讨论了物理性质，并将其与其他几个杂环系列的类似物进行了比较。
• Brown, Journal of Applied Chemistry, 1957, vol. 7, p. 109,112
  作者：Brown

  DOI：——

  日期：——
• 643. Pteridine derivatives. Part III. Bisdihydropurinyls
  作者：W. E. Fidler、H. C. S. Wood

  DOI：10.1039/jr9560003311

  日期：——
• Purine studies. Part I. Stability to acid and alkali. Solubility. Ionization. Comparison with pteridines
  作者：Adrien Albert、D. J. Brown

  DOI：10.1039/jr9540002060

  日期：——
• Conditioning of Skeletal Muscles in Adult and Old Mice for Protection From Contraction-Induced Injury
  作者：S. V. Brooks、J. A. Opiteck、J. A. Faulkner

  DOI：10.1093/gerona/56.4.b163

  日期：2001.4.1

  The purpose of this study was to design a conditioning program that protected muscles in both adult and old mice from a protocol of contractions that previously caused a significant number of damaged fibers and a deficit in force, Hind-limb dorsiflexor muscles of adult (7 months) and old (22 months) female B6D2F1 mice were exposed once a week to a protocol of repeated forced stretches while maximally activated in vivo. By week 4, muscles of adult, but not old, mice showed no force deficit. Conditioning was continued for 6 weeks, when both age groups showed no force deficit for two consecutive weeks. Three days after the sixth contraction protocol, when morphological damage and force deficits are most severe, the numbers of damaged fibers in muscles of adult and old mice were not different from those in uninjured control muscles and the force deficits were reduced dramatically compared with unconditioned muscles. We conclude that muscles of both adult and old mice conditioned successfully, but muscles of old mice conditioned more slowly than those of adult mice.