(3S)-N-benzyloxycarbonyl-3-aminomethyl-1-nitroheptane | 1445444-34-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3S)-N-benzyloxycarbonyl-3-aminomethyl-1-nitroheptane
• 英文别名: benzyl N-methyl-N-[(3S)-1-nitroheptan-3-yl]carbamate
• CAS: 1445444-34-7
• 化学式: C₁₆H₂₄N₂O₄
• 分子量: 308.378
• InChiKey: MZUXEFYFNQIOSO-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  75.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (3S)-N-benzyloxycarbonyl-3-aminomethyl-1-nitroheptane 在 溶剂黄146 、 sodium nitrite 作用下， 以 二甲基亚砜 为溶剂， 反应 20.0h， 以69%的产率得到(3S)-3-(methyl{[(phenylmethyl)oxy]carbonyl}amino)heptanoic acid
  参考文献：
  名称：

  A Mild Multistep Conversion of N-Protected α-Amino Acids into N-Protected β3-Amino Acids Utilizing the Nef Reaction

  摘要：

  Current methods of homologation of alpha-amino acids to beta-amino acids have limitations. To overcome these shortfalls the Nef reaction has been utilized in the multistep synthesis of beta(3)-amino acids from alpha-amino acids. In this approach, N-protected amino aldehydes, easily accessed from alpha-amino acids, were transformed into the N-protected.gamma-amino nitroalkanes. The Nef reaction was then used to smoothly convert the nitroalkanes into the corresponding N-protected beta(3)-amino acids without notable racemization.

  DOI：

  10.1055/s-0032-1318344
• 作为产物：
  描述：

  Z-n-me-l-2-氨基己酸 在 N-甲基吗啉 、 4-二甲氨基吡啶 、 potassium fluoride 、 sodium tetrahydroborate 、 草酰氯 、 二甲基亚砜 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 乙醇 、 二氯甲烷 、 水 、 异丙醇 为溶剂， 反应 13.17h， 生成 (3S)-N-benzyloxycarbonyl-3-aminomethyl-1-nitroheptane
  参考文献：
  名称：

  A Mild Multistep Conversion of N-Protected α-Amino Acids into N-Protected β3-Amino Acids Utilizing the Nef Reaction

  摘要：

  Current methods of homologation of alpha-amino acids to beta-amino acids have limitations. To overcome these shortfalls the Nef reaction has been utilized in the multistep synthesis of beta(3)-amino acids from alpha-amino acids. In this approach, N-protected amino aldehydes, easily accessed from alpha-amino acids, were transformed into the N-protected.gamma-amino nitroalkanes. The Nef reaction was then used to smoothly convert the nitroalkanes into the corresponding N-protected beta(3)-amino acids without notable racemization.

  DOI：

  10.1055/s-0032-1318344

文献信息

• A Mild Multistep Conversion of N-Protected α-Amino Acids into N-Protected β3-Amino Acids Utilizing the Nef Reaction
  作者：Andrew Hughes、Brad Sleebs、Nghi Nguyen

  DOI：10.1055/s-0032-1318344

  日期：——

  Current methods of homologation of alpha-amino acids to beta-amino acids have limitations. To overcome these shortfalls the Nef reaction has been utilized in the multistep synthesis of beta(3)-amino acids from alpha-amino acids. In this approach, N-protected amino aldehydes, easily accessed from alpha-amino acids, were transformed into the N-protected.gamma-amino nitroalkanes. The Nef reaction was then used to smoothly convert the nitroalkanes into the corresponding N-protected beta(3)-amino acids without notable racemization.