p-Benzyloxy-n-dodecylbenzol | 56441-73-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: p-Benzyloxy-n-dodecylbenzol
• 英文别名: 1-Dodecyl-4-phenylmethoxybenzene
• CAS: 56441-73-7
• 化学式: C₂₅H₃₆O
• 分子量: 352.56
• InChiKey: WQHGXWCYVMOXDT-UHFFFAOYSA-N

物化性质

• 沸点：
  180-190 °C(Press: 0.3 Torr)
• 密度：
  0.947±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.5
• 重原子数：
  26
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-十二烷基苯酚 、 氯化苄 在 sodium ethanolate 作用下， 生成 p-Benzyloxy-n-dodecylbenzol
  参考文献：
  名称：

  Hypolipidemic analogs of ethyl 4-benzyloxybenzoate

  摘要：

  A series of compounds related to ethyl 4-benzyloxybenzoate was synthesized and evaluated for potential hypolipidemic activity in rats. Structure--activity relationships are discussed in terms of cholesterol-lowering activity together with effects on weight gain and liver lipids. A number of the compounds inhibited cholesterol and free fatty acid biosynthesis from [1-14C]acetate in rat liver slices in vitro. Ethyl 4-benzyloxybenzoate, ethyl-4-benzyloxybenzoic acid, ethyl 4-p-bromobenzyloxybenzoates, and 4-o-methoxybenzyloxyphenyl acetate exhibited the most favorable spectrum of activity.

  DOI：

  10.1021/jm00221a007

文献信息

• Comparisons of Photo-Fries Rearrangements of 4-Dodecylphenyl Phenylacetate and Two Structurally Related Esters in Hexane and Polyethylene Cages. How Important Are Anchoring Chains?†
  作者：Chuping Luo、Philippe Passin、Richard G. Weiss

  DOI：10.1562/2005-05-26-ra-546

  日期：——

  Abstract Photo-Fries rearrangements of 4-dodecylphenyl phenylacetate have been investigated in polyethylene films with 0–71% crystallinity and in hexane over a range of temperatures. The results are compared to those reported previously from phenyl phenylacetate and 1-naphthyl tetradecanoate to assess the influence of a long alkyl chain on the in-cage motions of the intermediate singlet radical pairs

  摘要 4-十二烷基苯基乙酸酯的 Photo-Fries 重排已在 0-71% 结晶度的聚乙烯薄膜和己烷中在一定温度范围内进行了研究。将结果与先前报道的苯基乙酸酯和 1-萘基十四烷酸酯进行比较，以评估长烷基链对中间单线态自由基对的笼内运动的影响。结果表明，可以通过明智地放置长链取代基和选择特定的聚乙烯类型作为反应基质来调节紧密单线态自由基对的反应性和选择性。