8-羟基-2,4,6-辛三炔酰胺 | 544-44-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 8-羟基-2,4,6-辛三炔酰胺
• 英文名称: agrocybin
• 英文别名: 8-hydroxy-octa-2,4,6-triynoic acid amide；8-Hydroxy-octa-2,4,6-triinsaeure-amid；8-Hydroxy-octa-2,4,6-triinamid；8-hydroxyocta-2,4,6-triynamide
• CAS: 544-44-5
• 化学式: C₈H₅NO₂
• mdl: MFCD01711072
• 分子量: 147.133
• InChiKey: OXONWCQUZYDTNF-UHFFFAOYSA-N

物化性质

• 熔点：
  140° (conflagrates)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  8-羟基-2,4,6-辛三炔酰胺 在 palladium on barium sulfate 氢气 作用下， 以 甲醇 为溶剂， 生成 8-Hydroxy-7-methoxy-octanoic acid amide
  参考文献：
  名称：

  Tetra-acetylenic metabolites from Mycena viridimarginata

  摘要：

  DOI：

  10.1016/s0031-9422(00)80765-7
• 作为产物：
  描述：

  methyl 8-hydroxyocta-2,4,6-triynoate 在 ammonium hydroxide 作用下， 生成 8-羟基-2,4,6-辛三炔酰胺
  参考文献：
  名称：

  Ashworth et al., Journal of the Chemical Society, 1958, p. 950,952

  摘要：

  DOI：

文献信息

• ENZYME INHIBITING COMPOUNDS AND METHODS
  申请人：The Board of Trustees of the University of Illinois

  公开号：US20140100198A1

  公开（公告）日：2014-04-10

  The invention provides compounds, compositions, and methods for studying the Rohmer pathway and for treating bacterial infections or parasitic infections. The parasitic infection can be a protozoan infection, such as malaria. The compounds and compositions can also be used as antibiotics, for example, to kill bacteria or parasites, or to inhibit bacterial or parasite growth. The invention further provides inhibitors of isoprenoid biosynthesis enzymes, and methods of inhibiting the activity of isoprenoid biosynthesis enzymes. The compounds can be, for example, alkynes or allenes that bind to a unique Fe of an Fe 4 S 4 cluster of an isoprenoid biosynthesis enzyme.

  本发明提供了化合物、组合物和方法，用于研究Rohmer途径和治疗细菌感染或寄生虫感染。寄生虫感染可以是原虫感染，例如疟疾。这些化合物和组合物也可以用作抗生素，例如杀死细菌或寄生虫，或抑制细菌或寄生虫的生长。本发明还提供异戊二烯生物合成酶的抑制剂，以及抑制异戊二烯生物合成酶活性的方法。这些化合物可以是例如炔烃或联烯，它们与异戊二烯生物合成酶的Fe4S4簇的独特Fe结合。
• ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF
  申请人：Moderna Therapeutics, Inc.

  公开号：EP2755986A1

  公开（公告）日：2014-07-23
• US8609638B2
  申请人：——

  公开号：US8609638B2

  公开（公告）日：2013-12-17
• [EN] PIROMYCES EQUI CARBOHYDRATE BINDING DOMAINS<br/>[FR] DOMAINES DE FIXATION GLUCIDIQUES DE PIROMYCES EQUI
  申请人：BABRAHAM INST

  公开号：WO2000061760A1

  公开（公告）日：2000-10-19

  Novel carbohydrate binding domains are described which bind to galactomannan, beta glucan, arabinoxylan and cellulose. The domains can selectively discriminate in their binding activity between xylans, arabinoxylans and galactomannans of different plant species and can be used to selectively target agents to particular plant species.
• [EN] ENZYME INHIBITING COMPOUNDS AND METHODS<br/>[FR] COMPOSÉS ET PROCÉDÉS INHIBITEURS D'ENZYME
  申请人：UNIV ILLINOIS

  公开号：WO2011044505A2

  公开（公告）日：2011-04-14

  The invention provides compounds, compositions, and methods for studying the Rohmer pathway and for treating bacterial infections or parasitic infections. The parasitic infection can be a protozoan infection, such as malaria. The compounds and compositions can also be used as antibiotics, for example, to kill bacteria or parasites, or to inhibit bacterial or parasite growth. The invention further provides inhibitors of isoprenoid biosynthesis enzymes, and methods of inhibiting the activity of isoprenoid biosynthesis enzymes. The compounds can be, for example, alkynes or allenes that bind to a unique Fe of an Fe4S4 cluster of an isoprenoid biosynthesis enzyme.