2-phenyl-6-(2-hydroxyphenyl)-4-phenylphosphinine | 883448-62-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 2-phenyl-6-(2-hydroxyphenyl)-4-phenylphosphinine
• 英文别名: 2-(4,6-Diphenylphosphinin-2-yl)phenol
• CAS: 883448-62-2
• 化学式: C₂₃H₁₇OP
• 分子量: 340.361
• InChiKey: JJPDXJWSASKIGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-phenyl-6-(2-hydroxyphenyl)-4-phenylphosphinine 、 (R)-(1,1′-联萘-2,2′-二氧)氯膦 在 三乙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 以86%的产率得到13-[2-(4,6-Diphenylphosphinin-2-yl)phenoxy]-12,14-dioxa-13-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaene
  参考文献：
  名称：

  Chiral bidentate phosphabenzene-based ligands: synthesis, coordination chemistry, and application in Rh-catalyzed asymmetric hydrogenations

  摘要：

  Novel hydroxy-functionalized phosphabenzenes were synthesized, which provide the possibility to prepare chiral phosphabenzene-phosphites. These systems act as bidentate ligands toward rhodium centers and the corresponding metal complexes were applied in the rhodium-catalyzed asymmetric hydrogenation of prochiral substrates. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.01.049
• 作为产物：
  描述：

  2'-羟基查耳酮 在 tetrafluoroboric acid 、 氘代3-氨基-5-吗啉-4-甲基-恶唑-2-啉酮 、 三溴化硼 、 potassium carbonate 作用下， 以 乙醚 、 二氯甲烷 、 1,2-二氯乙烷 、 丙酮 、 乙腈 为溶剂， 反应 153.0h， 生成 2-phenyl-6-(2-hydroxyphenyl)-4-phenylphosphinine
  参考文献：
  名称：

  Chiral bidentate phosphabenzene-based ligands: synthesis, coordination chemistry, and application in Rh-catalyzed asymmetric hydrogenations

  摘要：

  Novel hydroxy-functionalized phosphabenzenes were synthesized, which provide the possibility to prepare chiral phosphabenzene-phosphites. These systems act as bidentate ligands toward rhodium centers and the corresponding metal complexes were applied in the rhodium-catalyzed asymmetric hydrogenation of prochiral substrates. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.01.049