9H-dibenzo[b,f][1,2,4]triazolo[4,3-d][1,4]diazepin-6-amine | 1217508-99-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 9H-dibenzo[b,f][1,2,4]triazolo[4,3-d][1,4]diazepin-6-amine
• CAS: 1217508-99-0
• 化学式: C₁₄H₁₁N₅
• 分子量: 249.275
• InChiKey: XXOLHHRRIZKCQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.57
• 重原子数：
  19.0
• 可旋转键数：
  0.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68.76
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  9H-dibenzo[b,f][1,2,4]triazolo[4,3-d][1,4]diazepin-6-amine 在 盐酸 、 sodium nitrite 、 氢溴酸 、 铜 作用下， 生成 6-bromo-9H-dibenzo[b,f][1,2,4]triazolo[4,3-d][1,4]diazepine
  参考文献：
  名称：

  Triazolo derivatives of dibenzodiazepines as potential c.n.s. Active drug

  摘要：

  The synthesis of a number of substituted triazolo derivatives of Dibenzodiazepines are reported. The medicinal properties were evaluated through various pharmacological assessments applied on albino mice of either sex taking clozapine as standard drug. A triazolo derivatives having substitution at 8-positions Dibenzodiazepines was found to have for better CNS depressant activity properties as compared to the basic Dibenzodiazepines moeity and among other 8-subsituted derivatives amino substitution exhibited 70 - 80 % antiepileptic properties.

  DOI：

  10.1515/hc.2009.15.2.141
• 作为产物：
  描述：

  甲酸 、 生成 9H-dibenzo[b,f][1,2,4]triazolo[4,3-d][1,4]diazepin-6-amine
  参考文献：
  名称：

  Triazolo derivatives of dibenzodiazepines as potential c.n.s. Active drug

  摘要：

  The synthesis of a number of substituted triazolo derivatives of Dibenzodiazepines are reported. The medicinal properties were evaluated through various pharmacological assessments applied on albino mice of either sex taking clozapine as standard drug. A triazolo derivatives having substitution at 8-positions Dibenzodiazepines was found to have for better CNS depressant activity properties as compared to the basic Dibenzodiazepines moeity and among other 8-subsituted derivatives amino substitution exhibited 70 - 80 % antiepileptic properties.

  DOI：

  10.1515/hc.2009.15.2.141