p-methoxyphenyl (4-O-acetyl-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-glucopyranoside)-(1→4)-(3,6-O-dibenzyl-2-deoxy-2-phthalimido-β-glucopyranoside)-(1→3)-2,3,4-tri-O-(4-methylbenzoyl)-β-D-glucoside | 1430068-21-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: p-methoxyphenyl (4-O-acetyl-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-glucopyranoside)-(1→4)-(3,6-O-dibenzyl-2-deoxy-2-phthalimido-β-glucopyranoside)-(1→3)-2,3,4-tri-O-(4-methylbenzoyl)-β-D-glucoside
• 英文别名: [(2R,3R,4S,5R,6S)-2-[[(2R,3R,4R,5S,6R)-5-[(2S,3R,4R,5S,6R)-5-acetyloxy-3-(1,3-dioxoisoindol-2-yl)-4-phenylmethoxy-6-(phenylmethoxymethyl)oxan-2-yl]oxy-3-(1,3-dioxoisoindol-2-yl)-4-phenylmethoxy-6-(phenylmethoxymethyl)oxan-2-yl]oxymethyl]-6-(4-methoxyphenoxy)-4,5-bis[(4-methylbenzoyl)oxy]oxan-3-yl] 4-methylbenzoate
• CAS: 1430068-21-5
• 化学式: C₉₅H₈₈N₂O₂₃
• 分子量: 1625.74
• InChiKey: MMKQSEGLHGVZHX-DTJVLVHNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.1
• 重原子数：
  120
• 可旋转键数：
  35
• 环数：
  15.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  282
• 氢给体数：
  0
• 氢受体数：
  23

反应信息

• 作为产物：
  描述：

  [(2R,3S,4R,5R,6S)-5-(1,3-dioxoisoindol-2-yl)-6-[(2R,3S,4R,5R,6S)-5-(1,3-dioxoisoindol-2-yl)-6-fluoro-4-phenylmethoxy-2-(phenylmethoxymethyl)oxan-3-yl]oxy-4-phenylmethoxy-2-(phenylmethoxymethyl)oxan-3-yl] acetate 、 Bz(4-Me)(-2)[Bz(4-Me)(-3)][Bz(4-Me)(-4)]Glc(b)-O-Ph(4-OMe) 在 hafnium(IV) trifluoromethanesulfonate 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以85%的产率得到p-methoxyphenyl (4-O-acetyl-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-glucopyranoside)-(1→4)-(3,6-O-dibenzyl-2-deoxy-2-phthalimido-β-glucopyranoside)-(1→3)-2,3,4-tri-O-(4-methylbenzoyl)-β-D-glucoside
  参考文献：
  名称：

  Hafnium(IV) Tetratriflate as a Glycosyl Fluoride Activation Reagent

  摘要：

  Hafnium(IV) tetratriflate was found to be a activator of glycosyl fluoride. The protocol was operationally simple and was widely applicable to a variety of substrates in both solid-phase and solution-phase glycosylation reactions.

  DOI：

  10.1021/jo400282x