2-Hydroxy-3-octyl-benzoesaeure, '3-Octyl-salicylsaeure' | 15417-04-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Hydroxy-3-octyl-benzoesaeure, '3-Octyl-salicylsaeure'
• 英文别名: n-Octylhydroxybenzoic acid；2-hydroxy-3-octylbenzoic acid
• CAS: 15417-04-6
• 化学式: C₁₅H₂₂O₃
• 分子量: 250.338
• InChiKey: APJQIANWLQBIFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Hydroxy-3-octyl-benzoesaeure, '3-Octyl-salicylsaeure' 、 3-氨基二氢-2(3H)-呋喃酮盐酸盐(1:1) 在 N-羟基-7-氮杂苯并三氮唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以81%的产率得到2-hydroxy-3-octyl-N-[(3S)-2-oxooxolan-3-yl]benzamide
  参考文献：
  名称：

  Novel synthetic analogs of the Pseudomonas autoinducer

  摘要：

  Release of virulence factors in Pseudomonas aeruginosa is regulated by two N-acylhomoserine lactones, PAI-I and PAI-2, that activate the respective transcription factors LasR and RhlR. With the goal of developing novel therapeutic agents, we synthesized constrained analogs of PAI-I and evaluated them in P. aeruginosa, Two of the novel analogs bound to LasR and showed agonist activity in LasR stimulation of a lasI-lacZ reporter construct. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00626-5
• 作为产物：
  描述：

  3-溴-2-甲氧基苯甲酸甲酯 在 palladium diacetate 、 BBr₃-SMe 、 三乙胺 、 三(邻甲基苯基)磷 作用下， 以 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 72.0h， 生成 2-Hydroxy-3-octyl-benzoesaeure, '3-Octyl-salicylsaeure'
  参考文献：
  名称：

  Novel synthetic analogs of the Pseudomonas autoinducer

  摘要：

  Release of virulence factors in Pseudomonas aeruginosa is regulated by two N-acylhomoserine lactones, PAI-I and PAI-2, that activate the respective transcription factors LasR and RhlR. With the goal of developing novel therapeutic agents, we synthesized constrained analogs of PAI-I and evaluated them in P. aeruginosa, Two of the novel analogs bound to LasR and showed agonist activity in LasR stimulation of a lasI-lacZ reporter construct. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00626-5

文献信息

• [EN] UV ABSORBING COMPOUNDS<br/>[FR] COMPOSÉS ABSORBANT LES UV
  申请人：FUJIFILM MFG EUROPE BV

  公开号：WO2009038463A1

  公开（公告）日：2009-03-26

  The invention relates to new, highly efficient UV - absorbing compounds, a process for their manufacturing and to uses of these UV - absorbing compounds. The UV - absorbing compounds are in particular UV - A - absorbing compounds according to Formula (VI) or (VII): R2CH2 - N(R17)-(CR12)m-N(R17)-CH2R2 (VI) N(R17)3-n[(CR12)m-N(R17)-CH2R2]n} (VII)

  这项发明涉及新型高效UV吸收化合物，其制造过程以及这些UV吸收化合物的用途。这些UV吸收化合物特别是根据化学式（VI）或（VII）的UV-A吸收化合物：R2CH2 - N(R17)-(CR12)m-N(R17)-CH2R2（VI）N(R17)3-n[(CR12)m-N(R17)-CH2R2]n}（VII）
• Cosmetic compositions
  申请人：——

  公开号：US20020106385A1

  公开（公告）日：2002-08-08

  The invention relates to cosmetic compositions comprising a combination of non-emulsifying and emulsifying crosslinked siloxane elastomers.

  这项发明涉及包含非乳化和乳化交联硅氧烷弹性体的化妆品组合物。
• Oil agent and lubricant agent, moisturizer and external preparation composition containing the same
  申请人：Takeda Kyoichi

  公开号：US20080200544A1

  公开（公告）日：2008-08-21

  The present invention provides an oil agent having water solubility and oil solubility, as well as suppressed stickiness when applied to skin to exhibit excellent feeling of use, and also provides a lubricating agent, a moisturizing agent and an external preparation containing said oil agent. The oil agent of the present invention comprises a dibasic acid ester compound of general formula I: wherein R 1 is an alkylene group having a carbon number of 2-4, which may be mono- or poly substituted, R 2 and R 3 are, independently of each other, an alkyl group having a carbon number of 1-4, which may be mono- or poly substituted, n and m are, independently of each other, an integer of 0-4 with m+n≧1 (provided that the cases wherein both of R 2 and R 3 are an ethyl group and both of n and m are 1 are excluded).

  本发明提供了一种具有水溶性和油溶性的油剂，当涂抹在皮肤上时，具有抑制粘性，展现出优秀的使用感受，同时提供了一种润滑剂、保湿剂和含有该油剂的外用制剂。本发明的油剂包括一种一般式I的二元酸酯化合物：其中R1是碳数为2-4的烷基基团，可以是单取代或多取代，R2和R3分别是碳数为1-4的烷基基团，可以是单取代或多取代，n和m分别是0-4的整数，满足m+n≥1（排除R2和R3均为乙基基团，n和m均为1的情况）。
• Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor
  申请人：Medinox, Inc.

  公开号：US20030181495A1

  公开（公告）日：2003-09-25

  The present invention provides novel combinations of dithiocarbamate disulfide dimers with other active agents. In one method, the disulfide derivative of a dithiocarbamate is coadministered with a thiazolidinedione for the treatment of diabetes. In another embodiment, In another embodiment, invention combinations further comprise additional active agents such as, for example, metformin, insulin, sulfonylureas, and the like. In another embodiment, the present invention relates to compositions and formulations useful in such therapeutic methods.

  本发明提供了二硫代氨基甲酸盐二硫化二聚体与其他活性药剂的新组合。在一种方法中，二硫代氨基甲酸盐的二硫化衍生物与噻唑烷二酮联合用于治疗糖尿病。在另一实施例中，该发明的组合进一步包括额外的活性药剂，例如二甲双胍、胰岛素、磺酰脲类药物等。在另一实施例中，本发明涉及用于这种治疗方法的组合物和配方。
• [EN] N-ARALKYLCARBONYL-PIPERAZINE AND -HOMOPIPERAZINE COMPOUNDS AND PERSONAL CARE COMPOSITIONS COMPRISING THE SAME<br/>[FR] COMPOSÉS DE N-ARALKYLCARBONYLE-PIPÉRAZINE ET N-ARALKYLCARBONYLE-HOMOPIPÉRAZINE ET COMPOSITIONS DE SOINS PERSONNELS LES COMPRENANT
  申请人：UNILEVER PLC

  公开号：WO2016173817A1

  公开（公告）日：2016-11-03

  A personal care composition comprising N-aralkylcarbonyl-piperazine and/or - homopiperazines. When such compounds are used in personal care compositions, they have been unexpectedly to enhance cell proliferation and epidermal thickness, traits associated with younger, healthy looking skin.

  一种包含N-芳基羰基哌嗪和/或-N-同源哌嗪的个人护理组合物。当这些化合物用于个人护理组合物中时，它们被意外地发现可以促进细胞增殖和表皮厚度增加，这些特征与年轻、健康肌肤有关。