6-(4-chloro-phenyl)-1,3-dimethyl-1,7-dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione | 41482-18-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 6-(4-chloro-phenyl)-1,3-dimethyl-1,7-dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione
• 英文别名: 6-(4-chlorophenyl)-1,3-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-dione
• CAS: 41482-18-2
• 化学式: C₁₄H₁₂ClN₃O₂
• 分子量: 289.721
• InChiKey: JFHCWTMYWDWOKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  56.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-氯苄基三苯基氯化磷蓊盐 在 sodium hydride 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 0.67h， 生成 6-(4-chloro-phenyl)-1,3-dimethyl-1,7-dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione
  参考文献：
  名称：

  Synthesis of pyrrolo[2,3-d]pyrimidine-2,4-diones by sunlight photolysis of N-(5-vinyluracil-6-yl)sulfilimines

  摘要：

  Uracil derivatives having a vinyl group at the C-5 position and a sulfilimine moiety at the C-6 position were prepared and cyclized to 1,3,6-trisubstituted pyrrolo[2,3-d]pyrimidine-2,4-diones by sunlight photolysis in good yields. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.06.054

文献信息

• Synthesis of pyrrolo[2,3-d]pyrimidine-2,4-diones by sunlight photolysis of N-(5-vinyluracil-6-yl)sulfilimines
  作者：Nobuaki Matsumoto、Masahiko Takahashi

  DOI：10.1016/j.tetlet.2005.06.054

  日期：2005.8

  Uracil derivatives having a vinyl group at the C-5 position and a sulfilimine moiety at the C-6 position were prepared and cyclized to 1,3,6-trisubstituted pyrrolo[2,3-d]pyrimidine-2,4-diones by sunlight photolysis in good yields. (c) 2005 Elsevier Ltd. All rights reserved.