2r,6c-bis-(4-methoxy-phenethyl)-1-methyl-piperidine | 47550-86-7

• 分子结构分类: 有机化合物 - 生物碱及其衍生物
• 英文名称: 2r,6c-bis-(4-methoxy-phenethyl)-1-methyl-piperidine
• 英文别名: 2r,6c-Bis-(4-methoxy-phenaethyl)-1-methyl-piperidin；(2R,6S)-2,6-bis[2-(4-methoxyphenyl)ethyl]-1-methylpiperidine
• CAS: 47550-86-7
• 化学式: C₂₄H₃₃NO₂
• 分子量: 367.532
• InChiKey: LGWKVDLUCCAJJF-SZPZYZBQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 、 溶剂黄146 、 铂 作用下， 生成 2r,6c-bis-(4-methoxy-phenethyl)-1-methyl-piperidine
  参考文献：
  名称：

  Piperidine derivatives and process for the manufacture of the same

  摘要：

  公开号：

  US02355659A1

文献信息

• 2,6-disubstituted piperidines and piperazine compounds
  申请人：——

  公开号：US20040266824A1

  公开（公告）日：2004-12-30

  The present invention is directed to 2,6-disubstituted piperidine and piperazine analogs having the following general formula: 1 which are used to treat diseases of the central nervous system, drug abuse, and withdrawal therefrom as well as treating eating disorders.

  本发明涉及具有以下一般式的2,6-二取代哌啶和哌嗪类似物：1，用于治疗中枢神经系统疾病、药物滥用及其戒断，以及治疗进食障碍。
• Lobelane analogues as novel ligands for the vesicular monoamine transporter-2
  作者：Guangrong Zheng、Linda P. Dwoskin、Agripina G. Deaciuc、Jun Zhu、Marlon D. Jones、Peter A. Crooks

  DOI：10.1016/j.bmc.2005.04.013

  日期：2005.6

  A series of lobelane analogues has been synthesized and their structure-activity relationships at the vesicular monoamine transporter-2 (VMAT2) have been evaluated. The most potent analogues in this series were the cis-2,6-piperidino analogues, 25b, 27b, 28b, and 30b, with K-i ranging from 430 to 580 nM.. (c) 2005 Elsevier Ltd. All rights reserved.
• Piperidine derivatives and process for the manufacture of the same
  申请人：HOFFMANN LA ROCHE

  公开号：US02355659A1

  公开（公告）日：1944-08-15
• US7368443B2
  申请人：——

  公开号：US7368443B2

  公开（公告）日：2008-05-06
• PIPERIDINE DERIVATIVES. PART 1. LOBELAN AND RELATED COMPOUNDS
  作者：JOHN LEE、WERNER FREUDENBERG

  DOI：10.1021/jo01188a007

  日期：1944.11