N-[4-(4-cyanophenoxy)-butyl]-diethylamine | 46926-57-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-[4-(4-cyanophenoxy)-butyl]-diethylamine
• 英文别名: 4-[4-(diethylamino)butoxy]benzonitrile
• CAS: 46926-57-2
• 化学式: C₁₅H₂₂N₂O
• 分子量: 246.352
• InChiKey: NBCMGDKWRZNVRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  36.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-[4-(4-cyanophenoxy)-butyl]-diethylamine 、 Lithium aluminium hydride 生成 4-[4-(diethylamino)butoxy]benzylamine
  参考文献：
  名称：

  Imidazoquinazoline derivatives

  摘要：

  本发明涉及由公式（I）表示的咪唑喹噁啉衍生物：##STR1## 其中，R.sup.1代表氢、取代或未取代的低碳基、环烷基、取代或未取代的芳基甲基、取代或未取代的芳基、取代或未取代的杂芳基甲基或取代或未取代的杂芳基，R.sup.2和R.sup.3分别表示氢、取代或未取代的低碳基、取代或未取代的芳基甲基、取代或未取代的芳基、取代或未取代的杂芳基甲基或取代或未取代的杂芳基，或R.sup.2和R.sup.3结合表示含有一个氮原子的杂环基，R.sup.4代表氢或取代或未取代的低碳基，X代表O或S，Y代表单键或O，n代表0、1、2或3，以及其药学上可接受的盐。

  公开号：

  US05698560A1
• 作为产物：
  描述：

  4-(4-溴丁氧基)苯甲腈 、 二乙胺 以 乙醇 为溶剂， 生成 N-[4-(4-cyanophenoxy)-butyl]-diethylamine
  参考文献：
  名称：

  一些芳氧基烷基胺，N-芳基乙二胺和相关化合物作为厌食剂。

  摘要：

  DOI：

  10.1021/jm00291a015

文献信息

• Non-imidazole aryloxy (or arylthio) alkylamines as histamine H3-receptor antagonists and their therapeutic applications
  申请人：SOCIETE CIVILE BIOPROJET

  公开号：EP0978512A1

  公开（公告）日：2000-02-09

  Compounds of formula (I): and their use for preparing medicaments acting as antagonists at the H3-receptors of histamine.

  式(I)的化合物及其用于制备作为组胺H3受体拮抗剂的药物。
• Non-imidazole alkylamines as histamine H3-receptor ligands and their therapeutic applications
  申请人：——

  公开号：US20040220225A1

  公开（公告）日：2004-11-04

  Use of a compound of formula (A), wherein: 1 W is a residue which imparts antagonistic and/or agonistic activity at histamine H 3 -receptors when attached to an imidazole ring in 4(5) position; R 1 and R 2 may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H 3 -receptors of histamine.

  使用式(A)的化合物，其中：1W是一个残基，当附加在咪唑环的4(5)位时，赋予组合物在组胺H3受体上的拮抗和/或激动活性；R1和R2可以相同也可以不同，分别独立地表示较低的烷基或环烷基，或者与它们所连接的氮原子一起，表示饱和的含氮环(i)、非芳香性不饱和含氮环(ii)、吗啡环或N-取代哌嗪环，用于制备在组胺H3受体上作为拮抗剂和/或激动剂的药物。
• Non-imidazole alkylamines as histamine H3- receptor ligands and their therapeutic applications
  申请人：Schwartz Jean-Charles

  公开号：US20060247223A1

  公开（公告）日：2006-11-02

  Use of a compound of formula (A), wherein: W is a residue which imparts antagonistic and/or agonistic activity at histamine H 3 -receptors when attached to an imidazole ring in 4(5) position; R 1 and R 2 may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H 3 -receptors of histamine.

  使用公式（A）中的化合物，其中： W是一个残留物，当附加到咪唑环的4（5）位时，赋予组织胺H3受体的拮抗和/或激动活性； R1和R2可以相同也可以不同，并且独立地表示较低的烷基或环烷基，或者与它们附着的氮原子一起，表示饱和的含氮环（i）如定义，非芳香性不饱和含氮环（ii）如定义，吗啉基或N-取代的哌嗪基，如定义，用于制备作为组织胺H3受体的拮抗剂和/或激动剂的药物。
• NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS
  申请人：SCHWARTZ Jean-Charles

  公开号：US20110281844A1

  公开（公告）日：2011-11-17

  Use of a compound of formula (A), wherein: W is a residue which imparts antagonistic and/or agonistic activity at histamine H 3 -receptors when attached to an imidazole ring in 4(5) position; R 1 and R 2 may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H 3 -receptors of histamine.

  使用公式（A）中的化合物，其中： W是一个残基，当连接到咪唑环的4（5）位置时，赋予组合物在组胺H3受体上的拮抗和/或激动活性；R1和R2可能相同也可能不同，且分别独立地代表较低的烷基或环烷基，或者与它们连接的氮原子一起，代表饱和的含氮环（i），如所定义，非芳香性不饱和含氮环（ii），如所定义，吗啡啶基团，或所定义的N-取代哌嗪基团，以制备在组胺H3受体上作为拮抗剂和/或激动剂的药物。
• IMIDAZOQUINAZOLINE DERIVATIVES
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP0758653A1

  公开（公告）日：1997-02-19

  Imidazoquinazoline derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein R1 represents hydrogen, optionally substituted lower alkyl, etc.; R2 and R3 are the same or different and each represents hydrogen, optionally substituted lower alkyl, optionally substituted aralkyl, optionally substituted aryl, etc., or R2 and R3 together form an optionally substituted nitrogenous heterocycle; R4 represents hydrogen or optionally substituted lower alkyl; X represents O or S; Y represents a single bond or O; and n is 0, 1, 2 or 3.

  由通式(I)代表的咪唑喹唑啉衍生物或其药理上可接受的盐，其中R1代表氢、任选取代的低级烷基等；R2和R3相同或不同，各自代表氢、任选取代的低级烷基、任选取代的芳烷基、任选取代的芳基等，或R2和R3一起形成任选取代的含氮杂环；R4代表氢或任选取代的低级烷基；X代表O或S；Y代表单键或O；n为0、1、2或3。