3,4-bis-[5-(4-cyano-phenoxy)-pentyloxy]-benzonitrile | 103278-74-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3,4-bis-[5-(4-cyano-phenoxy)-pentyloxy]-benzonitrile
• 英文别名: 3,4-Bis-[5-(4-cyan-phenoxy)-pentyloxy]-benzonitril；3,4-Bis[5-(4-cyanophenoxy)pentoxy]benzonitrile
• CAS: 103278-74-6
• 化学式: C₃₁H₃₁N₃O₄
• 分子量: 509.605
• InChiKey: GZYDCUZHXOLZJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  38
• 可旋转键数：
  16
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  108
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3,4-二羟基苯腈 、 4-[(5-bromopentyl)oxy]benzonitrile 生成 3-hydroxy-4,4'-pentanediyldioxy-di-benzonitrile 、 3,4-bis-[5-(4-cyano-phenoxy)-pentyloxy]-benzonitrile
  参考文献：
  名称：

  Davis, Journal of the Chemical Society, 1958, p. 907

  摘要：

  DOI：

文献信息

• USES OF PENTAMIDINE AND RELATED COMPOUNDS
  申请人：Berglund John Andrew

  公开号：US20100323993A1

  公开（公告）日：2010-12-23

  Methods are provided herein for treatment of myotonic dystrophy and other toxic RNA diseases in a subject. In some examples, the method comprises administration of a compound that binds a nucleotide repeat expansion in a ribonucleic acid molecule, thereby treating the disease. In additional examples, the method comprises administration of a compound that disrupts binding of muscleblind-like proteins to an RNA nucleotide repeat expansion. Compounds for use in the disclosed method include pentamidine or heptamidine or derivatives thereof. Representative compounds are described herein.

  本文提供了一种治疗肌无力萎缩症和其他毒性RNA疾病的方法。在某些例子中，该方法包括给受体注射一种化合物，该化合物能够结合核糖核酸分子中的核苷酸重复扩展，从而治疗该疾病。在其他例子中，该方法包括给受体注射一种化合物，该化合物能够破坏肌肉盲样蛋白与RNA核苷酸重复扩展的结合。用于该方法的化合物包括戊二酸二甲胺或庚二酸二甲胺或其衍生物。本文描述了代表性化合物。
• US8436049B2
  申请人：——

  公开号：US8436049B2

  公开（公告）日：2013-05-07
• [EN] USES OF PENTAMIDINE AND RELATED COMPOUNDS<br/>[FR] UTILISATIONS DE PENTAMIDINE ET DE COMPOSÉS ASSOCIÉS
  申请人：OREGON STATE

  公开号：WO2009105691A2

  公开（公告）日：2009-08-27

  Methods are provided herein for treatment of myotonic dystrophy and other toxic RNA diseases in a subject. In some examples, the method comprises administration of a compound that binds a nucleotide repeat expansion in a ribonucleic acid molecule, thereby treating the disease. In additional examples, the method comprises administration of a compound that disrupts binding of muscleblind-like proteins to an RNA nucleotide repeat expansion. Compounds for use in the disclosed method include pentamidine or heptamidine or derivatives thereof. Representative compounds are described herein.