(2,3-Dimethylbutan-2-yl)(trimethyl)silane | 90420-68-1

• 分子结构分类: 有机化合物 - 碳氢化合物衍生物
• 英文名称: (2,3-Dimethylbutan-2-yl)(trimethyl)silane
• 英文别名: 2,3-dimethylbutan-2-yl(trimethyl)silane
• CAS: 90420-68-1
• 化学式: C₉H₂₂Si
• 分子量: 158.359
• InChiKey: ISDKMLJDJZKLPW-UHFFFAOYSA-N

物化性质

• 沸点：
  151.5±9.0 °C(Predicted)
• 密度：
  0.742±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.76
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (2,3-Dimethylbutan-2-yl)(trimethyl)silane 、 phenyl 2-O-benzoyl-3-O-benzyl-1-thio-α-L-idopyranoside 在 吡啶 、 4-二甲氨基吡啶 作用下， 以85%的产率得到phenyl 2-O-benzoyl-3-O-benzyl-6-O-(dimethylthexysilyl)-1-thio-α-L-idopyranoside
  参考文献：
  名称：

  Toward the Solid-Phase Synthesis of Heparan Sulfate Oligosaccharides: Evaluation of Iduronic Acid and Idose Building Blocks

  摘要：

  Glycan arrays have been established as the premier technical platform for assessing the specificity of carbohydrate binding proteins, an important step in functional glycomics research. Access to large libraries of well-characterized oligosaccharides remains a major bottleneck of glycan array research, and this is particularly true for glycosaminoglycans (GAGs), a class of linear sulfated polysaccharides which are present on most animal cells. Solid-supported synthesis is a potentially powerful tool for the accelerated synthesis of relevant GAG libraries with variations in glycan sequence and sulfation pattern. We have evaluated a series of iduronic acid and idose donors, including a couple of novel n-pentenyl orthoester donors in the sequential assembly of heparan sulfate precursors from monosaccharide building blocks in solution and on a polystyrene resin. The systematic study of donor and acceptor performance up to the trisaccharide stage in solution and on the solid support have resulted in a general strategy for the solid-phase assembly of this important class of glycans.

  DOI：

  10.1021/jo400467g
• 作为产物：
  描述：

  甲基锂 、 hexamethylsilirane 在 lithium bromide 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 0.25h， 以18%的产率得到(2,3-Dimethylbutan-2-yl)(trimethyl)silane
  参考文献：
  名称：

  Hexamethylsilirane

  摘要：

  DOI：

  10.1016/0022-328x(84)85140-2

文献信息

• Hexamethylsilirane. Simple, isolable silacyclopropane
  作者：Dietmar Seyferth、Dennis C. Annarelli

  DOI：10.1021/ja00841a048

  日期：1975.4
• SEYFERTH, D.;WISEMAN, G. H.;ANNARELLI, D. C.;SHANNON, M. L., J. ORGANOMET. CHEM., 1984, 264, N 1-2, 149-153
  作者：SEYFERTH, D.、WISEMAN, G. H.、ANNARELLI, D. C.、SHANNON, M. L.

  DOI：——

  日期：——
• Toward the Solid-Phase Synthesis of Heparan Sulfate Oligosaccharides: Evaluation of Iduronic Acid and Idose Building Blocks
  作者：Nerea Guedes、Pawel Czechura、Begoña Echeverria、Ada Ruiz、Olatz Michelena、Manuel Martin-Lomas、Niels-Christian Reichardt

  DOI：10.1021/jo400467g

  日期：2013.7.19

  Glycan arrays have been established as the premier technical platform for assessing the specificity of carbohydrate binding proteins, an important step in functional glycomics research. Access to large libraries of well-characterized oligosaccharides remains a major bottleneck of glycan array research, and this is particularly true for glycosaminoglycans (GAGs), a class of linear sulfated polysaccharides which are present on most animal cells. Solid-supported synthesis is a potentially powerful tool for the accelerated synthesis of relevant GAG libraries with variations in glycan sequence and sulfation pattern. We have evaluated a series of iduronic acid and idose donors, including a couple of novel n-pentenyl orthoester donors in the sequential assembly of heparan sulfate precursors from monosaccharide building blocks in solution and on a polystyrene resin. The systematic study of donor and acceptor performance up to the trisaccharide stage in solution and on the solid support have resulted in a general strategy for the solid-phase assembly of this important class of glycans.
• Hexamethylsilirane
  作者：Dietmar Seyferth、Gary H. Wiseman、Dennis C. Annarelli、Mark L. Shannon

  DOI：10.1016/0022-328x(84)85140-2

  日期：1984.3