ethyl 2-{4-[3-amino-5-(4-fluorophenoxy)phenoxy]phenyl}-2-(benzyloxycarbonylamino)acetate | 1428901-23-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 2-{4-[3-amino-5-(4-fluorophenoxy)phenoxy]phenyl}-2-(benzyloxycarbonylamino)acetate
• 英文别名: Ethyl 2-[4-[3-amino-5-(4-fluorophenoxy)phenoxy]phenyl]-2-(phenylmethoxycarbonylamino)acetate；ethyl 2-[4-[3-amino-5-(4-fluorophenoxy)phenoxy]phenyl]-2-(phenylmethoxycarbonylamino)acetate
• CAS: 1428901-23-8
• 化学式: C₃₀H₂₇FN₂O₆
• 分子量: 530.553
• InChiKey: ANXSHEVWHOKFCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  39
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  3,5-二氟硝基苯 在 盐酸 、 potassium phosphate 、 bis(tri-tert-butylphosphine)palladium(0) 、 铁粉 、 碳酸氢钠 、 氯化铵 、 caesium carbonate 、 锌 作用下， 以 乙二醇二甲醚 、 乙醇 、 N,N-二甲基乙酰胺 、 水 、 乙酸乙酯 、 甲苯 为溶剂， 反应 60.0h， 生成 ethyl 2-{4-[3-amino-5-(4-fluorophenoxy)phenoxy]phenyl}-2-(benzyloxycarbonylamino)acetate
  参考文献：
  名称：

  PHENYL DERIVATIVE

  摘要：

  公开号：

  EP2762466B1

文献信息

• MOLECULAR TEMPLATE AND METHOD FOR PRODUCING SAME
  申请人：Hitachi, Ltd.

  公开号：EP2762884A1

  公开（公告）日：2014-08-06

  The method and apparatus for detecting a chemical substance of the present invention perform the detection of a chemical substance by capturing the chemical substance with a capturing body prepared by utilizing a molecular template. The present invention provides a chemical sensor easy to use for general consumers at home as well as for medical personnel (medical doctors, medical technicians and nurses). In particular, an object of the present invention is to diagnose the symptom of stress disorder by detecting, with high sensitivity, a steroid hormone such as cortisol closely related to stress disorder, and to herewith contribute to the prevention and early treatment of stress disorder. The present invention provides a molecular template for a steroid hormone, including a polymer to interact with the steroid hormone. The polymer preferably includes, in the polymerization unit thereof, two or more functional groups to interact with the steroid hormone.

  本发明的化学物质检测方法和装置是通过利用分子模板制备的捕捉体捕捉化学物质来进行化学物质检测的。本发明提供了一种易于使用的化学传感器，不仅适用于普通家庭消费者，也适用于医务人员（医生、医疗技术人员和护士）。特别是，本发明的目的是通过高灵敏度地检测与应激障碍密切相关的类固醇激素（如皮质醇）来诊断应激障碍症状，从而有助于预防和早期治疗应激障碍。本发明提供了一种类固醇激素的分子模板，包括一种与类固醇激素相互作用的聚合物。聚合物最好在其聚合单元中包括两个或两个以上与类固醇激素相互作用的官能团。
• Phenyl derivative
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：US10117861B2

  公开（公告）日：2018-11-06

  The compound of the formula (I-1): wherein all the symbols have the same meanings as described in the specification, has two cyclic groups, particularly phenoxy groups at specific substitution positions and thus has high human S1P2 antagonistic activity. The compound may therefore be used as a therapeutic agent for S1P2-mediated diseases such as diseases resulting from vascular constriction, fibrosis, and respiratory diseases.

  式 (I-1) 的化合物： 其中所有符号的含义与说明书中所述的相同，具有两个环状基团，特别是特定取代位置上的苯氧基，因此具有较高的人体 S1P2 拮抗活性。因此，该化合物可用作 S1P2 介导的疾病（如血管收缩、纤维化和呼吸系统疾病引起的疾病）的治疗剂。
• Molecular Template and Method for Producing Same
  申请人：Takeuchi Toshifumi

  公开号：US20140227798A1

  公开（公告）日：2014-08-14

  The method and apparatus for detecting a chemical substance of the present invention perform the detection of a chemical substance by capturing the chemical substance with a capturing body prepared by utilizing a molecular template. The present invention provides a chemical sensor easy to use for general consumers at home as well as for medical personnel (medical doctors, medical technicians and nurses). In particular, an object of the present invention is to diagnose the symptom of stress disorder by detecting, with high sensitivity, a steroid hormone such as cortisol closely related to stress disorder, and to herewith contribute to the prevention and early treatment of stress disorder. The present invention provides a molecular template for a steroid hormone, including a polymer to interact with the steroid hormone. The polymer preferably includes, in the polymerization unit thereof, two or more functional groups to interact with the steroid hormone.
• CHEMICAL ANALYSIS APPARATUS
  申请人：HITACHI, LTD.

  公开号：US20180196017A1

  公开（公告）日：2018-07-12

  Provided is a chemical analysis apparatus configured to quickly quantify and detect target molecules at low costs with high-sensitivity. A chemical analysis apparatus 600 includes a pretreating unit 60 in which a capturing body 61 that captures a target molecule using a molecularly imprinted polymer interacting with the target molecule included in a specimen is accommodated, a specimen introducing unit 62 that supplies the specimen to the pretreating unit 60 , a desorbing liquid supplying unit 67 that supplies a desorbing liquid, which desorbs the target molecule from the capturing body 61 , to the pretreating unit 60 , and a quantifying unit 65 that quantifies the target molecules desorbed from the capturing body 61 using the desorbing liquid.
• US8975409B2
  申请人：——

  公开号：US8975409B2

  公开（公告）日：2015-03-10