methyl 1-diphenylmethylaminoethyl phosphinate | 437608-54-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 1-diphenylmethylaminoethyl phosphinate
• 英文别名: N-benzhydryl-1-[methoxy(oxido)phosphaniumyl]ethanamine
• CAS: 437608-54-3
• 化学式: C₁₆H₂₀NO₂P
• 分子量: 289.314
• InChiKey: LAAAMWNZYCNMGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  44.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl α-butylacrylate 、 methyl 1-diphenylmethylaminoethyl phosphinate 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 生成 Methyl 2-[[1-(benzhydrylamino)ethyl-methoxyphosphoryl]methyl]hexanoate
  参考文献：
  名称：

  A Convenient One-Pot Synthesis of Phosphino-Dipeptide Analogs

  摘要：

  A general "one-pot" synthetic method is described for the preparation of phosphinodipeptides of type 1, in 60-80% overall yield, allowing the variation of the substituents in alpha and/or beta position to the phosphorus atom and also in a position to the nitrogen atom.

  DOI：

  10.1080/10426500212259
• 作为产物：
  描述：

  methyl hypophosphite 、 N-benzhydrylethanimine 以 甲醇 为溶剂， 反应 1.0h， 生成 methyl 1-diphenylmethylaminoethyl phosphinate
  参考文献：
  名称：

  A Convenient One-Pot Synthesis of Phosphino-Dipeptide Analogs

  摘要：

  A general "one-pot" synthetic method is described for the preparation of phosphinodipeptides of type 1, in 60-80% overall yield, allowing the variation of the substituents in alpha and/or beta position to the phosphorus atom and also in a position to the nitrogen atom.

  DOI：

  10.1080/10426500212259

文献信息

• Preparation of phosphinodipeptide analogs as building blocks for pseudopeptides synthesis
  作者：Henri-Jean Cristau、Agnès Coulombeau、Arielle Genevois-Borella、Frédéric Sanchez、Jean-Luc Pirat

  DOI：10.1016/s0022-328x(01)01238-4

  日期：2002.2

  A simple and effective preparation of phosphinodipeptides, in good overall yields, has been developed, This one pot procedure, allowing the variation of the substituents in alpha and/or beta position to the phosphorus atom and also in alpha position to the nitrogen atom, consists in the addition of alkyl hypophosphites to imines. followed by Michael-addition on acrylates. To show the value of phosphinodipeptides analogs I as synthetic intermediates, selective deprotections of the three functional groups are described. (C) 2002 Elsevier Science B.V. All rights reserved.
• A Convenient One-Pot Synthesis of Phosphino-Dipeptide Analogs
  作者：Jean-Luc Pirat、Agnes Coulombeau、Arielle Genevois-Borella、Henri-Jean Cristau

  DOI：10.1080/10426500212259

  日期：2002.6.1

  A general "one-pot" synthetic method is described for the preparation of phosphinodipeptides of type 1, in 60-80% overall yield, allowing the variation of the substituents in alpha and/or beta position to the phosphorus atom and also in a position to the nitrogen atom.