6-phenyl-1-(4-tolylsulfonyl)-1,6-dihydropyridine-2,5-dione | 235787-78-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-phenyl-1-(4-tolylsulfonyl)-1,6-dihydropyridine-2,5-dione
• 英文别名: 1-(4-methylphenyl)sulfonyl-2-phenyl-2H-pyridine-3,6-dione
• CAS: 235787-78-7
• 化学式: C₁₈H₁₅NO₄S
• 分子量: 341.387
• InChiKey: VMBSLZZAPMYPED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  79.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-phenyl-1-(4-tolylsulfonyl)-1,6-dihydropyridine-2,5-dione 在 sodium azide 、 sodium acetate 作用下， 以 甲醇 、 溶剂黄146 为溶剂， 以77%的产率得到3-amino-6-phenyl-1-(4-tolylsulfonyl)-1,6-dihydropyridine-2,5-dione
  参考文献：
  名称：

  1,4-Reductive Addition of Hydrazoic Acid to γ-Oxo-α,β-unsaturated δ-Lactones and -Lactams: A Convenient Route to α-Amino-γ-oxo-α,β-unsaturated δ-Lactones and -Lactams

  摘要：

  gamma-Oxo-alpha,beta-unsaturated delta-lactones and lactams, which are easily accessible from their corresponding 2-furylcarbinols, were used as substrates for the 1,4-reductive addition of hydrazoic acid. The outcome of the reaction is the formation, in high yields, of the corresponding alpha-amino-gamma-oxo-alpha,beta-unsaturated delta-lactones and -lactams, compounds of great biological and synthetic interest.

  DOI：

  10.1002/(sici)1099-0690(199906)1999:6<1449::aid-ejoc1449>3.0.co;2-9
• 作为产物：
  描述：

  2-[叠氮基(苯基)甲基]呋喃 在 palladium on activated charcoal jones reagent 、 氢气 、 三乙胺 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 氯仿 、 乙酸乙酯 、 丙酮 为溶剂， 20.0 ℃ 、100.0 kPa 条件下， 反应 3.92h， 生成 6-phenyl-1-(4-tolylsulfonyl)-1,6-dihydropyridine-2,5-dione
  参考文献：
  名称：

  1,4-Reductive Addition of Hydrazoic Acid to γ-Oxo-α,β-unsaturated δ-Lactones and -Lactams: A Convenient Route to α-Amino-γ-oxo-α,β-unsaturated δ-Lactones and -Lactams

  摘要：

  gamma-Oxo-alpha,beta-unsaturated delta-lactones and lactams, which are easily accessible from their corresponding 2-furylcarbinols, were used as substrates for the 1,4-reductive addition of hydrazoic acid. The outcome of the reaction is the formation, in high yields, of the corresponding alpha-amino-gamma-oxo-alpha,beta-unsaturated delta-lactones and -lactams, compounds of great biological and synthetic interest.

  DOI：

  10.1002/(sici)1099-0690(199906)1999:6<1449::aid-ejoc1449>3.0.co;2-9