methyl 2-(tosylamino)hex-5-enoate | 750638-86-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 2-(tosylamino)hex-5-enoate
• 英文别名: Methyl 2-[(4-methylphenyl)sulfonylamino]hex-5-enoate
• CAS: 750638-86-9
• 化学式: C₁₄H₁₉NO₄S
• 分子量: 297.375
• InChiKey: XBPXOJCFVABJCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  80.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  一氧化碳 、 methyl 2-(tosylamino)hex-5-enoate 在 二(氰基苯)二氯化钯 、 三苯基硅烷 作用下， 以 三氟甲苯 为溶剂， 反应 0.17h， 生成 methyl (2R,5S)-1-(4-methylphenyl)sulfonyl-5-(2-oxoethyl)pyrrolidine-2-carboxylate 、
  参考文献：
  名称：

  Development of Oxidative Formylation and Ketonylation Reactions

  摘要：

  The first oxidative formylation and oxidative ketonylation of alkenylamines and alkenyl alcohols is demonstrated. A range of substrates that participate in this process are provided. Oxidative formylation was found to proceed optimally with the use of triphenylsilane as the hydride source. Oxidative ketonylation was feasible with a number of organometallic partners, especially dialkylzinc or organostannanes. An interesting finding regarding the fate of various acylpalladium intermediates is discussed.

  DOI：

  10.1055/s-0029-1218663
• 作为产物：
  描述：

  对甲苯磺酰氯 、 Methyl 2-aminohex-5-enoate 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以241 mg的产率得到methyl 2-(tosylamino)hex-5-enoate
  参考文献：
  名称：

  Development of Oxidative Formylation and Ketonylation Reactions

  摘要：

  The first oxidative formylation and oxidative ketonylation of alkenylamines and alkenyl alcohols is demonstrated. A range of substrates that participate in this process are provided. Oxidative formylation was found to proceed optimally with the use of triphenylsilane as the hydride source. Oxidative ketonylation was feasible with a number of organometallic partners, especially dialkylzinc or organostannanes. An interesting finding regarding the fate of various acylpalladium intermediates is discussed.

  DOI：

  10.1055/s-0029-1218663