1-Butyl-5-methyl-1,2,4-triazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-Butyl-5-methyl-1,2,4-triazole
• 化学式: C₇H₁₃N₃
• 分子量: 139.2
• InChiKey: VXMGSUISZDGWMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-丁基-1H-1,2,4-三唑 、 碘甲烷 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以41%的产率得到1-Butyl-5-methyl-1,2,4-triazole
  参考文献：
  名称：

  Selective Reactivity of sp³ and sp² Carbanions of 1-Substituted 1,2,4-Triazoles. A Comparative Approach

  摘要：

  The regioselectivity of lithiation reactions of 1-n-alkyl-, 1-allyl-, and 1-propargyl-1H-1,2,4-triazoles was studied in terms of the products formed by sequential treatment with BuLi and a range of electrophiles.

  DOI：

  10.1021/jo9800659

文献信息

• DRUG COMBINATIONS COMPRISING A DGAT INHIBITOR AND A PPAR-AGONIST
  申请人：Linders Joannes Theodorus Maria

  公开号：US20110112111A1

  公开（公告）日：2011-05-12

  The present invention relates to combinations of a DGAT inhibitor and a peroxisome proliferator-activator receptor (PPAR) agonist or a prodrug thereof. The invention further relates to methods for preparing such combinations, pharmaceutical compositions comprising said combinations as well as the use as a medicament of said combinations. The present invention also relates to novel DGAT inhibitors. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicament of said compounds.

  本发明涉及一种DGAT抑制剂和过氧化物酶体增殖激活受体（PPAR）激动剂或其前药的组合物。本发明还涉及制备这种组合物的方法，以及包含该组合物的制药组合物和该组合物作为药物的用途。本发明还涉及新型的DGAT抑制剂。本发明还涉及制备这种化合物的方法，以及包含该化合物的制药组合物和该化合物作为药物的用途。
• PIPERIDINE/PIPERAZINE DERIVATIVES
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2152271B1

  公开（公告）日：2015-10-21
• VERFAHREN ZUR VERBESSERUNG DER HYDROLYSESTABILITÄT IONISCHER FLÜSSIGKEITEN
  申请人：BASF SE

  公开号：EP2229365A1

  公开（公告）日：2010-09-22
• Drug combinations comprising a DGAT inhibitor and a PPAR-agonist
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2296659B1

  公开（公告）日：2016-12-21
• METHOD FOR IMPROVING THE HYDROLYSIS STABILITY OF IONIC LIQUIDS
  申请人：Degen Georg

  公开号：US20100267596A1

  公开（公告）日：2010-10-21

  The present invention relates to a method for improving the hydrolysis stability of an ionic liquid (IL), in which at least one tertiary amine or one quaternary ammonium compound different from the ionic liquid (IL) is added to an ionic liquid (IL).