(5R,6R,8R,9S)-8-phenyl-5,9,10-trimethyl-1,3,7-trioxa-10-azaspiro[5.5]undecan-11-one | 916607-05-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: (5R,6R,8R,9S)-8-phenyl-5,9,10-trimethyl-1,3,7-trioxa-10-azaspiro[5.5]undecan-11-one
• 英文别名: (2R,3S,6R,11R)-3,4,11-trimethyl-2-phenyl-1,7,9-trioxa-4-azaspiro[5.5]undecan-5-one
• CAS: 916607-05-1
• 化学式: C₁₆H₂₁NO₄
• 分子量: 291.347
• InChiKey: FQKRNXKRDXVKIS-DSPQJCBJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  48
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (5R,6R,8R,9S)-8-phenyl-5,9,10-trimethyl-1,3,7-trioxa-10-azaspiro[5.5]undecan-11-one 在 三氟化硼乙醚 、 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Enantioselective Synthesis of Functionalized Medium-Sized Oxacycles

  摘要：

  Enantioselective routes to functionalized, seven-, eight-, and nine-membered oxacycles that are amenable to further elaboration have been developed. Salient features of the methodology include highly diastereoselective and regioselective transformations of an ephedrine-derived epoxy morpholinone to functionalized precursors of the oxacycles. The ephedrine scaffold exerts remote stereocontrol in the functionalization of the appended oxacycle.

  DOI：

  10.1021/ol062484v
• 作为产物：
  描述：

  5S,6R-4,5-dimethyl-6-phenyl-morpholin-2,3-dione 在 硫酸 、 三氟化硼乙醚 、 溶剂黄146 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 29.0h， 生成 (5R,6R,8R,9S)-8-phenyl-5,9,10-trimethyl-1,3,7-trioxa-10-azaspiro[5.5]undecan-11-one
  参考文献：
  名称：

  Enantioselective Synthesis of Functionalized Medium-Sized Oxacycles

  摘要：

  Enantioselective routes to functionalized, seven-, eight-, and nine-membered oxacycles that are amenable to further elaboration have been developed. Salient features of the methodology include highly diastereoselective and regioselective transformations of an ephedrine-derived epoxy morpholinone to functionalized precursors of the oxacycles. The ephedrine scaffold exerts remote stereocontrol in the functionalization of the appended oxacycle.

  DOI：

  10.1021/ol062484v