Reaction of hydrogen fluoride in pyridine solution with -cyano-2 and -amido-2-aziridines. Preparation of β-fluoro α-amino acids and esters by means of acidic hydrolysis and alcoholysis of β-fluoro-α-aminonitriles and/or β-fluoro-α-amino acid amides
作者:Ayicoué Ayi、Roger Guedj
DOI:10.1016/s0022-1139(00)85554-2
日期:1983.11
The addition of hydrogen fluoride generated from pyridinium poly(hydrogen fluoride) ( Olah's reagent) to some -2-cyano and -2-amido aziridines has been examined.
已研究了将吡啶鎓聚氟化氢(奥拉试剂)产生的氟化氢添加到某些-2-氰基和-2-氨基氮丙啶上。
Deoxyradiofluorination Reaction from β-Hydroxy-α-aminoesters: an Entry to [<sup>18</sup>
F]Fluoroaminoesters under Mild Conditions
作者:Marine Morlot、Fabienne Gourand、Cécile Perrio
DOI:10.1002/ejoc.201900300
日期:2019.6.23
Deoxyradiofluorination of β‐hydroxy‐α‐aminoesters was successfully achieved at room temperature using [18F]fluoride anion. The reaction involved an aziridinium intermediate and yielded the corresponding [18F]fluorinated α or β‐aminoesters in good radiochemical yields. Regioselectivity was dependent on the nature of substituents R1–R4.