N-methyl-11-bromoundecylamide | 34639-53-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-methyl-11-bromoundecylamide
• 英文别名: 11-bromo-N-methylundecanamide；N-Methyl-11-bromundecanamid
• CAS: 34639-53-7
• 化学式: C₁₂H₂₄BrNO
• 分子量: 278.233
• InChiKey: BFKNAMAMYOLEBX-UHFFFAOYSA-N

物化性质

• 沸点：
  388.9±15.0 °C(Predicted)
• 密度：
  1.132±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-methyl-11-bromoundecylamide 在 氢氧化钾 作用下， 以 乙醇 、 溶剂黄146 为溶剂， 反应 16.0h， 生成 N-methyl-11-hydroxyundecylamide
  参考文献：
  名称：

  Robinson, Derek I.; Sherrington David C.; Suckling, Colin J., Journal of Chemical Research, Miniprint, 1985, # 5, p. 1701 - 1728

  摘要：

  DOI：
• 作为产物：
  描述：

  11-溴十一酸 在 草酰氯 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 7.0h， 生成 N-methyl-11-bromoundecylamide
  参考文献：
  名称：

  Replacing −CH₂CH₂– with −CONH– Does Not Significantly Change Rates of Charge Transport through Ag^TS-SAM//Ga₂O₃/EGaIn Junctions

  摘要：

  This paper describes physical-organic studies of charge transport by tunneling through self-assembled monolayers (SAMs), based on systematic variations of the structure of the molecules constituting the SAM. Replacing a -CH2CH2- group with a -CONH- group changes the dipole moment and polarizability of a portion of the molecule and has, in principle, the potential to change the rate of charge transport through the SAM. In practice, this substitution produces no significant change in the rate of charge transport across junctions of the structure Ag-TS-S(CH2)(m)X(CH2)(n)H//Ga2O3/EGaIn (TS = template stripped, X = -CH2CH2- or -CONH-, and EGaIn = eutectic alloy of gallium and indium). Incorporation of the amide group does, however, increase the yields of working (non-shorting) junctions (when compared to n-alkanethiolates of the same length). These results suggest that synthetic schemes that combine a thiol group on one end of a molecule with a group, R, to be tested, on the other (e.g., HS similar to CONH similar to R) using an amide-based coupling provide practical routes to molecules useful in studies of molecular electronics.

  DOI：

  10.1021/ja301778s

文献信息

• ZWITTERIONIC NANOPARTICLES
  申请人：FRAUNHOFER-INSTITUT FÜR ANGEWANDTE POLYMERFOSCHUNG IAP

  公开号：US20190367807A1

  公开（公告）日：2019-12-05

  The present invention relates to a zwitterionic nanoparticle, the zwitterionic nanoparticle comprising at least one nanoparticle and a zwitterionic case enclosing the nanoparticle. Furthermore, the present invention relates to a composition, a method of binding a zwitterionic nanoparticle and the use of a zwitterionic nanoparticle.

  本发明涉及一种带有至少一个纳米粒子和包围该纳米粒子的带电离子外壳的带电离子纳米粒子。此外，本发明涉及一种组合物，一种结合带电离子纳米粒子的方法以及使用带电离子纳米粒子。
• Metallation reactions. Part X. Allylic metallation in the presence of amide groups: long range interactions
  作者：S. Glily-Terry、J. Klein

  DOI：10.1039/j39710003821

  日期：——

  butyl-lithium in ether or in hexane α to the amide groups and/or at the doubly allylic position, without addition to the carbonyl group. The ratio of the products depends on the solvent. Metallations of NN-dimethyl-linoleamine were also obtained. The positions of carbonation of these lithium derivatives revealed a long-range effect of the functional groups. A series of octadecanoic acids with one additional

  亚油酸的N-甲基酰胺通过丁基锂在醚或己烷α中金属化成酰胺基团和/或在双烯丙基位置，而不加羰基。产物的比例取决于溶剂。的Metallations NN也得到二甲基linoleamine。这些锂衍生物的碳酸化位置揭示了官能团的长期作用。为了比较，制备了在链的各个位置具有一个另外的羧基的一系列十八烷酸。在酰胺的四甲基乙二胺具有共轭的两个双键的存在下的金属化产物将丁基锂加成到二烯上。
• Synthesis of Chimeric 7α-Substituted Estradiol Derivatives Linked to Cholesterol and Cholesterylamine
  作者：Stephen L. Hussey、Enfei He、Blake R. Peterson

  DOI：10.1021/ol0171261

  日期：2002.2.1

  We report the synthesis of 7alpha-substituted beta-estradiol derivatives bearing side chains terminated with cholesterol and 3beta-cholesterylamine. These chimeric compounds were designed to exhibit high affinity for estrogen receptors (ERs) and cellular plasma membranes to potentially enable regulated uptake of ERs by mammalian cells. Evaluation with recombinant yeast reporting compound-mediated ER dimerization revealed potencies similar to the antiestrogen ICI 182780. Compounds that efficiently deliver dominant negative ERs into cells may provide novel therapeutics against breast cancers.
• VERWENDUNG EINES ZWITTERIONISCHE NANOPARTIKEL
  申请人：Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

  公开号：EP3571262B1

  公开（公告）日：2022-12-21
• [DE] ZWITTERIONISCHE NANOPARTIKEL<br/>[EN] ZWITTERIONIC NANOPARTICLES<br/>[FR] NANOPARTICULES ZWITTERIONIQUES
  申请人：FRAUNHOFER INST FUER ANGEWANDTE POLYMERFOSCHUNG IAP

  公开号：WO2018134344A1

  公开（公告）日：2018-07-26

  Die vorliegende Erfindung betrifft ein zwitterionisches Nanopartikel, wobei das zwitterionische Nanopartikel wenigstens ein Nanopartikel und eine zwitterionische Hülle aufweist, die das Nanopartikel umschließt. Darüber hinaus betrifft die vorliegende Erfindung eine Zusammensetzung, ein Verfahren zur Anbindung eines zwitterionischen Nanopartikels und die Verwendung eines zwitterionischen Nanopartikels.