5-Bromo-3-[(Z)-4-(4-chloro-phenyl)-6-p-tolyl-pyrimidin-2-ylimino]-1,3-dihydro-indol-2-one | 251983-28-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-Bromo-3-[(Z)-4-(4-chloro-phenyl)-6-p-tolyl-pyrimidin-2-ylimino]-1,3-dihydro-indol-2-one
• 英文别名: 5-bromo-3-[4-(4-chlorophenyl)-6-(4-methylphenyl)pyrimidin-2-yl]imino-1H-indol-2-one
• CAS: 251983-28-5
• 化学式: C₂₅H₁₆BrClN₄O
• 分子量: 503.785
• InChiKey: YDAKLJJQIJKKCH-UHFFFAOYSA-N

物化性质

• 密度：
  1.53±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  哌啶 、 聚合甲醛 、 5-Bromo-3-[(Z)-4-(4-chloro-phenyl)-6-p-tolyl-pyrimidin-2-ylimino]-1,3-dihydro-indol-2-one 以 四氢呋喃 为溶剂， 以81%的产率得到(3Z)-5-bromo-3-[4-(4-chlorophenyl)-6-(p-tolyl)pyrimidin-2-yl]imino-1-(1-piperidylmethyl)indolin-2-one
  参考文献：
  名称：

  Syrltllesis and Alltituberculous activity of N-Mannich bases of 3-[4-(4 chloropheny1)-6-(4-methylphesyl) pyrimidin-2-yl] iminoisatin derivatives

  摘要：

  结核病正在全球范围内复苏。

  DOI：

  10.3797/scipharm.aut-02-05
• 作为产物：
  描述：

  5-溴靛红 、 4-(4-chlorophenyl)-6-(4-methylphenyl)-2-aminopyrimidine 以 乙醇 、 溶剂黄146 为溶剂， 以57%的产率得到5-Bromo-3-[(Z)-4-(4-chloro-phenyl)-6-p-tolyl-pyrimidin-2-ylimino]-1,3-dihydro-indol-2-one
  参考文献：
  名称：

  Syrltllesis and Alltituberculous activity of N-Mannich bases of 3-[4-(4 chloropheny1)-6-(4-methylphesyl) pyrimidin-2-yl] iminoisatin derivatives

  摘要：

  结核病正在全球范围内复苏。

  DOI：

  10.3797/scipharm.aut-02-05

文献信息

• Synthesis and antimicrobial activity of Schiff and Mannich bases of isatin and its derivatives with pyrimidine
  作者：S.N Pandeya、D Sriram、G Nath、E De Clercq

  DOI：10.1016/s0014-827x(99)00075-0

  日期：1999.9

  Isatin and its derivatives have been reacted with 4-(4'-chlorophenyl)-6-(4"-methyl phenyl)-2-aminopyrimidine to form Schiff bases and the N-Mannich bases of these compounds were synthesized by reacting them with formaldehyde and several secondary amines. Investigation of antimicrobial activity of the compounds was made by the agar dilution method against 28 pathogenic bacteria, eight pathogenic fungi and anti-HIV activity against replication of HIV-I (III B) in MT-4 cells. The compounds are significantly active against bacteria and fungi. (C) 1999 Elsevier Science S.A. All rights reserved.
• Syrltllesis and Alltituberculous activity of N-Mannich bases of 3-[4-(4 chloropheny1)-6-(4-methylphesyl) pyrimidin-2-yl] iminoisatin derivatives
  作者：Sriram D.、Yogeeswari P.、Pandeya S.N.、Ananthan S.

  DOI：10.3797/scipharm.aut-02-05

  日期：——

  Tuberculosis is making a worldwide resurgence [...]

  结核病正在全球范围内复苏。