isopropyl 2-chloroacrylate | 44811-29-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: isopropyl 2-chloroacrylate
• 英文别名: 2-chloro-acrylic acid isopropyl ester；2-Chlor-acrylsaeure-isopropylester；Chloro isopropyl acrylate；propan-2-yl 2-chloroprop-2-enoate
• CAS: 44811-29-2
• 化学式: C₆H₉ClO₂
• 分子量: 148.589
• InChiKey: IFUUJJJOOHDTAT-UHFFFAOYSA-N

物化性质

• 沸点：
  47 °C(Press: 6 Torr)
• 密度：
  1.0810 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  isopropyl 2-chloroacrylate 、 N-甲氧基苯甲酰胺 在 silver hexafluoroantimonate 、 dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer 、 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 12.0h， 以86%的产率得到isopropyl 2-methoxy-1-oxo-1,2-dihydroisoquinoline-3-carboxylate
  参考文献：
  名称：

  铑 (III) 催化 (4 + 2) 环化合成异喹诺酮、1,2-苯并噻嗪和萘并[1',2':4,5]咪唑并[1,2-a]吡啶衍生物

  摘要：

  在这项研究中，我们报告了一种新颖且有效的合成方法，通过Rh(III) 催化的 (4 + 2) 苯甲酰胺与未报道的偶联试剂 2-氯丙烯酸甲酯的环化来构建异喹诺酮支架。因此，其他有价值的1,2-苯并噻嗪和萘并[1',2':4,5]咪唑并[1,2- a ]吡啶衍生物也通过类似的合成方案获得。因此，我们开发的方法以高产率和反应多功能性为特色。

  DOI：

  10.1021/acs.joc.2c01376
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium carbonate 、 对苯二酚 、 甘油 作用下， 生成 isopropyl 2-chloroacrylate
  参考文献：
  名称：

  Production of alpha-haloacrylic compounds

  摘要：

  公开号：

  US02434229A1

文献信息

• Manufacture of halogenated organic acids containing three carbon atoms and derivatives thereof
  申请人：ICI LTD

  公开号：US02233835A1

  公开（公告）日：1941-03-04

  514,619. Organic acids and their derivatives. McLEISH, N., CRAWFORD, J. W: C., and IMPERIAL CHEMICAL INDUSTRIES, Ltd. Feb. 10, 1938, Nos. 4264, 5209, and 8051. [Class 2 (iii)] Chlorine-containing organic acids or functional derivatives thereof such as the metal salts, esters and chlorides, are prepared by causing formaldehyde or a polymer thereof to react with trichlorethylene in the presence of sulphuric acid of not less than 80 per cent. concentration, and subsequently heating the reaction mixture to a temperature of at least 80‹ C. and preferably to at least 120‹ C. in the presence of water and (or) an alcohol. A compound COCl.CHCl.CH2HSO4 appears to be first formed, which on gentle heating is converted to an acid or ester still containing the -CH2HSO4 grouping, but on stronger heating gives a hydroxy acid, an unsaturated acid or esters of such acids. If the amount of water present is at least 1.5 times the weight of sulphuric acid, chlorohydracrylic acid is produced, and if the amount of water is less than this, alpha-chloracrylic compounds mainly result, or the chlorohydracrylic acid may be dehydrated to form chloracrylic acid. Esters may be prepared by adding methyl, ethyl, propyl, isopropyl, n-butyl, secondary butyl, n-amyl, benzyl, #-phenyl ethyl alcohol or cyclic alcohols such as cyclohexanol and methyl cyclohexanol. Polymerization of the acids or esters is prevented during reaction by a small amount of resorcinol, hydroquinone, pyrogallol, copper, sulphur or tannic acid. Salts may be prepared by treating the crude acids with oxides, hydroxides or carbonates of sodium, potassium, lithium, barium, strontium, calcium, magnesium, iron, copper, lead, zinc or mercury. Examples are given of the preparation of alpha-chloracrylic acid, its barium salt and its methyl, ethyl, n-propyl, isopropyl and n-butyl esters, alpha-chloracrylic chloride, chlorohydracrylic acid and its ethyl-ester. Methyl-alpha, #-dichloropropionate is also formed in the reactions.

  514,619. 有机酸及其衍生物。麦克利什（McLEISH，N.），克劳福德（CRAWFORD，J. W. C.）和帝国化学工业有限公司（IMPERIAL CHEMICAL INDUSTRIES, Ltd.）。1938年2月10日，编号4264、5209和8051。[2类（iii）] 含氯有机酸或其功能衍生物，如金属盐、酯和氯化物，是通过使甲醛或其聚合物在不少于80％浓度的硫酸存在下与三氯乙烯反应，随后在水和（或）醇的存在下将反应混合物加热至至少80℃，最好至少120℃而制备的。似乎首先形成了一个COCl.CHCl.CH2HSO4化合物，轻轻加热后转化为仍然含有-CH2HSO4基团的酸或酯，但在更强的加热下会产生羟基酸、不饱和酸或这些酸的酯。如果存在的水量至少是硫酸重量的1.5倍，则产生氯水化丙烯酸，如果水量小于此，则主要产生α-氯丙烯酸化合物，或氯水化丙烯酸可以脱水形成氯丙烯酸。可以通过添加甲基、乙基、丙基、异丙基、正丁基、次丁基、正戊基、苄基、#-苯乙醇或环醇（如环己醇和甲基环己醇）来制备酯。在反应过程中，通过少量的间苯二酚、醌、邻苯二酚、铜、硫或丹宁酸防止酸或酯的聚合。可以通过用氧化物、氢氧化物或碳酸盐处理钠、钾、锂、钡、锶、钙、镁、铁、铜、铅、锌或汞的粗酸来制备盐。给出了制备α-氯丙烯酸、其钡盐及其甲基、乙基、正丙基、异丙基和正丁基酯、α-氯丙烯酰氯、氯水化丙烯酸及其乙酯的示例。在反应中还生成甲基-α，#-二氯丙酸酯。
• Method for production of a sealed coating for surfaces of buildings comprising a cross-linked sealed silicone membrane, adhesive and ready-to-use kit for application of said method
  申请人：——

  公开号：US20040234786A1

  公开（公告）日：2004-11-25

  The invention relates to a method for production of a sealed surface coating, for buildings (floor/wall/ceiling), of the type where a series of layers, or elements are fixed on the surface, comprising, starting from the surface, optionally at least one primer adhesive layer, at least one watertight polymer membrane, (optionally at least one woven or non-woven fibrous material layer), at least one layer of adhesive and at least one external cover, characterised in that (a) the sealed membrane is chosen from those which may be obtained from a an aqueous dispersion of silicone oil(s), (b) the adhesive applied comprises at least one adhesion promoter (C′), (c) the aqueous dispersion of silicone oil(s) is applied as a film to the surface, (d) the cross-linking of the silicone layer occurs subsequently, preferably at an ambient temperature, (e) the application of at last one layer of adhesive with added adhesion promoter (C′) is then applied, preferably by surface coating on the cross-linked silicone film and finally the external cover is applied.

  本发明涉及一种用于建筑物（地板/墙壁/天花板）密封表面涂层的生产方法，其中在表面固定一系列层或元素，包括从表面开始，可选地至少一种底漆粘合层，至少一种防水聚合物膜层，（可选地至少一种编织或非编织纤维材料层），至少一种粘合层和至少一种外部覆盖层，其特征在于（a）密封膜是从硅油水分散液中获得的膜之一，（b）应用的粘合剂包括至少一种粘附剂（C'），（c）硅油水分散液被涂覆在表面上形成一膜，（d）硅层的交联随后发生，最好在室温下进行，（e）然后应用至少一层添加粘附剂（C'）的粘合剂，最好通过在交联的硅膜上进行表面涂层，最后应用外部覆盖层。
• Aqueous dispersion based of viscous silicone oils crosslinkable by condensation into an adhering elastomer for use in particular as sealants or paints, preparation method
  申请人：——

  公开号：US20040054070A1

  公开（公告）日：2004-03-18

  The invention concerns an aqueous dispersion of viscous silicone oils capable of being crosslinked into an elastomer by water elimination (condensation). The invention aims at obtaining an aqueous silicone dispersion corresponding to an optimal compromise in terms of adherence of the crosslinked elastomer on all types of supports, and the colloidal stability of the dispersion during preparation and storage. Said aqueous dispersion comprises a viscous silicone oil A, optionally a crosslinking agent B, optionally an adhesion promoter C (silane), a filler D, a catalyst E, an emulsifier F, optionally a functional additive G and water. Said dispersion is characterised in that the filler D is input into the process for obtaining the dispersion, in the form of an aqueous suspension of at least a hydrophilic compound (CaCO3SiO2, TiO2, Al2/H2O, organic polymer latex). The invention also concerns the preparation of said particularly stable dispersion since it has a residual emulsion rate T not less than 70%. The invention is useful for producing concentrated sealants and elastomer coating for insulating polymer foam (polyurethane).

  本发明涉及一种粘性有机硅油的水分散体，能够通过水消除（缩合）交联成弹性体。本发明旨在获得一种水性有机硅分散体，以在制备和储存期间实现交联弹性体对所有类型支撑物的粘附和分散稳定性的最佳折衷。所述水性分散体包括粘性有机硅油A，可选交联剂B，可选粘附剂C（硅烷），填料D，催化剂E，乳化剂F，可选功能性添加剂G和水。所述分散体的特征在于，填料D以至少一种亲水化合物（CaCO3SiO2，TiO2，Al2/H2O，有机聚合物乳液）的水悬浮液的形式输入到获得分散体的过程中。本发明还涉及制备该特别稳定分散体的方法，因为它具有不少于70％的残留乳化率T。本发明有助于生产浓缩密封剂和用于绝缘聚合物泡沫（聚氨酯）的弹性体涂层。
• INK COMPOSITION, INKJET RECORDING METHOD AND PROCESS FOR PRODUCING MOLDED PRINTED MATERIAL
  申请人：MOCHIZUKI Kyohei

  公开号：US20110242191A1

  公开（公告）日：2011-10-06

  An ink composition is provided that includes (Component a) an open-chain and/or cyclic ether bond-containing monofunctional (meth)acrylate, (Component b) one or more monofunctional ethylenically unsaturated compounds selected from the group consisting of a polycyclic aliphatic group-containing monofunctional (meth)acrylate and N-vinyl-2-caprolactam, (Component c) a polymerization initiator, (Component e) a polyfunctional (meth)acrylate at no greater than 10 wt % relative to the ink composition, and (Component f) a fluorine-substituted hydrocarbon group- or siloxane structure-containing polymer, the ratio by weight of (Component a)/(Component b) being 0.7 to 1.9. There are also provided an inkjet recording method that includes (a 1 ) an image formation step of forming an image above a recording medium by discharging the ink composition by an inkjet method and (b 1 ) a curing step of curing the ink composition by irradiating the obtained image with actinic radiation to thus obtain a cured image above the recording medium, and a process for producing a molded printed material that includes (a 2 ) an image formation step of forming an image above a recording medium by discharging the ink composition by an inkjet method, (b 2 ) a curing step of curing the ink composition by irradiating the obtained image with actinic radiation to thus obtain a printed material having a cured image above the recording medium, and (c 2 ) a molding step of molding the printed material.

  提供了一种墨水组合物，包括（组分a）一种开链和/或环状醚键含有单官能基（甲基）丙烯酸酯，（组分b）一种或多种单官能基乙烯基不饱和化合物，所述化合物选自包含多环脂肪族基的单官能基（甲基）丙烯酸酯和N-乙烯基-2-己内酰胺的群组，（组分c）一种聚合引发剂，（组分e）一种多官能基（甲基）丙烯酸酯，相对于墨水组合物不大于10重量％，以及（组分f）一种含有氟代烃基或硅氧烷结构的聚合物，其中（组分a）/（组分b）的重量比为0.7到1.9。还提供了一种喷墨记录方法，包括（a1）通过喷墨方法排放墨水组合物形成记录介质上的图像形成步骤和（b1）通过照射获得的图像进行光致固化的固化步骤，从而在记录介质上获得固化图像，以及一种生产模塑印刷材料的过程，包括（a2）通过喷墨方法排放墨水组合物形成记录介质上的图像形成步骤，（b2）通过照射获得的图像进行光致固化的固化步骤，从而在记录介质上获得具有固化图像的印刷材料，以及（c2）模塑印刷材料的模塑步骤。
• Stable allergenic extracts and methods
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0107832A2

  公开（公告）日：1984-05-09

  A storage-stable, high potency allergenic extract is prepared by ultrafiltration, retaining fractions having molecular weights of from 1000 to 100,000, and treating the solution with gel polymer and/or carbon absorbents. The extract is dried to a moisture content of less than one weight percent water. The purified solution and aqueous reconstituted solutions of the dried extract provide a transparent, colorless solution which has greatly increased stability, remaining transparent and colorless for extended periods.

  通过超滤，保留分子量在 1000 到 100,000 之间的馏分，并用凝胶聚合物和/或碳吸收剂处理溶液，制备出储存稳定的高活性过敏原提取物。提取物经干燥后，水分含量小于 1%。纯化后的溶液和干燥提取物的重配水溶液可提供透明无色的溶液，其稳定性大大提高，可长时间保持透明无色。