N-benzoyl-anthranilic acid p-anisidide | 73343-44-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzoyl-anthranilic acid p-anisidide
• 英文别名: N-Benzoyl-anthranilsaeure-p-anisidid；N-Benzoyl-anthranilsaeure-(4-methoxy-anilid)；2-benzamido-N-(4-methoxyphenyl)benzamide
• CAS: 73343-44-9
• 化学式: C₂₁H₁₈N₂O₃
• 分子量: 346.386
• InChiKey: LXBJYZZMIIFFAG-UHFFFAOYSA-N

物化性质

• 熔点：
  233 °C
• 沸点：
  404.7±30.0 °C(Predicted)
• 密度：
  1.277±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-benzoyl-anthranilic acid p-anisidide 在 zinc(II) chloride 作用下， 反应 0.17h， 以10%的产率得到3-(4-methoxyphenyl)-2-phenylquinazolin-4(3H)-one
  参考文献：
  名称：

  Synthesis and anti-inflammatory activity of 2,3-diaryl-4(3H)-quinazolinones

  摘要：

  DOI：

  10.1007/s10593-006-0201-4
• 作为产物：
  描述：

  2-(苯甲酰基氨基)苯甲酸 在 氯化亚砜 作用下， 生成 N-benzoyl-anthranilic acid p-anisidide
  参考文献：
  名称：

  Familial Aggregation of 7-Year Changes in Musculoskeletal Fitness

  摘要：

  The purpose of this study was to determine the degree of familial resemblance in baseline and 7-year changes in musculoskeletal fitness. Data front the 1981 Canada Fitness Survey and the Campbell's Survey 7-year follow-up were used. The sample consisted of 1264 people (635 males and 629 females) between the ages of 7 and 69 years for whom measurements of musculoskeletal fitness were available at baseline. A subsample of 834 people had measurements at both baseline and 7-year follow-up. Sit-and-reach trunk flexibility, number of push-ups without time limit, number of sit-ups in 60 seconds, and hand-grip strength were used as indicators of musculoskeletal fitness. The data were adjusted for the effects of age and body mass index (and baseline level of the variable for changes) by using regression procedures, and they were standardized to zero mean and unit variance within each of the four sex-by-generation groups (fathers, mothers, sons, and daughters), Familial correlation models were fitted to the data by using the computer software SEGPATH. The results indicate significant familial resemblance for all indicators of musculoskeletal fitness for baseline measures and 7-year changes. The heritabilities, or the percentages of the total variance attributable to heredity, were 64% for trunk flexibility, 37% for push-ups, 59% for sit-ups, and 48% for grip strength. Similarly, heritabilities for the change scores were 48% for trunk flexibility, 52% for push-ups, 41% for sit-ups, and 32% for grip strength. The results suggest that familial, and perhaps genetic, factors are important in explaining the variance in musculoskeletal fitness not only cross-sectionally but also for changes over time.

  DOI：

  10.1093/gerona/56.12.b497

文献信息

• Synthesis and anti-inflammatory activity of 2,3-diaryl-4(3H)-quinazolinones
  作者：M. R. Yadav、S. T. Shirude、A. Parmar、R. Balaraman、R. Giridhar

  DOI：10.1007/s10593-006-0201-4

  日期：2006.8
• Familial Aggregation of 7-Year Changes in Musculoskeletal Fitness
  作者：P. T. Katzmarzyk、N. Gledhill、L. Perusse、C. Bouchard

  DOI：10.1093/gerona/56.12.b497

  日期：2001.12.1

  The purpose of this study was to determine the degree of familial resemblance in baseline and 7-year changes in musculoskeletal fitness. Data front the 1981 Canada Fitness Survey and the Campbell's Survey 7-year follow-up were used. The sample consisted of 1264 people (635 males and 629 females) between the ages of 7 and 69 years for whom measurements of musculoskeletal fitness were available at baseline. A subsample of 834 people had measurements at both baseline and 7-year follow-up. Sit-and-reach trunk flexibility, number of push-ups without time limit, number of sit-ups in 60 seconds, and hand-grip strength were used as indicators of musculoskeletal fitness. The data were adjusted for the effects of age and body mass index (and baseline level of the variable for changes) by using regression procedures, and they were standardized to zero mean and unit variance within each of the four sex-by-generation groups (fathers, mothers, sons, and daughters), Familial correlation models were fitted to the data by using the computer software SEGPATH. The results indicate significant familial resemblance for all indicators of musculoskeletal fitness for baseline measures and 7-year changes. The heritabilities, or the percentages of the total variance attributable to heredity, were 64% for trunk flexibility, 37% for push-ups, 59% for sit-ups, and 48% for grip strength. Similarly, heritabilities for the change scores were 48% for trunk flexibility, 52% for push-ups, 41% for sit-ups, and 32% for grip strength. The results suggest that familial, and perhaps genetic, factors are important in explaining the variance in musculoskeletal fitness not only cross-sectionally but also for changes over time.