(2-hydroxy-4-methoxyphenyl)-morpholin-4-ylmethanone | 53930-84-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-hydroxy-4-methoxyphenyl)-morpholin-4-ylmethanone
• 英文别名: (2-hydroxy-4-methoxyphenyl)(morpholino)methanone；2-hydroxy-4-methoxy-benzoic acid morpholide
• CAS: 53930-84-0
• 化学式: C₁₂H₁₅NO₄
• mdl: MFCD08524367
• 分子量: 237.255
• InChiKey: OECXXBUSZDYBMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2-hydroxy-4-methoxyphenyl)-morpholin-4-ylmethanone 在 叔丁基过氧化氢 、 copper diacetate 作用下， 以 癸烷 、 乙腈 为溶剂， 反应 1.0h， 以84%的产率得到2-methoxy-5-(morpholine-4-carbonyl)cyclohexa-2,5-diene-1,4-dione
  参考文献：
  名称：

  Synthesis of functionalized carbamates and quinones via sequential oxidation of salicylaldehydes using TBHP as the oxidant

  摘要：

  A sequential oxidative approach was designed to functionalize salicylaldehyde derivatives and provide corresponding bi-functional amide-carbamate and amide-quinone units. A combination of metal/metal free conditions and TBHP as the external oxidant provided the products in moderate to excellent yields (49-91%). (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.09.080
• 作为产物：
  描述：

  吗啉基(4-甲氧基苯基)甲酮 在 正丁基锂 、 双氧水 、 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 2.56h， 生成 (2-hydroxy-4-methoxyphenyl)-morpholin-4-ylmethanone
  参考文献：
  名称：

  取代吗啉苯甲酰胺的原位锂化原位硼化

  摘要：

  吗啉酰胺是Weinreb酰胺作为有机金属物种酰化剂的廉价且安全的替代品。在此，已经研究了18种邻位间和对位取代的吗啉苯甲酰胺的原位锂化/硼化。18种底物中的10种提供了所需的硼酸酯作为主要异构体（> 90％的区域选择性），分离出的粗品收率为68％至93％。随后通过激酶抑制剂的合成说明了此类构件的合成可用性。

  DOI：

  10.1016/j.tet.2017.02.002

文献信息

• 2-Phenyl-imidazo (4,5-b)pyridines and salts thereof
  申请人：Boehringer Ingelheim GmbH

  公开号：US03985891A1

  公开（公告）日：1976-10-12

  Compounds of the isomeric formulas ##SPC1## Wherein R.sub.1 is alkoxy of 1 to 4 carbon atoms, allyloxy, benzyloxy, methoxy-ethoxy, methylthio, methylsulfinyl, methylsulfonyl or methylsulfinylethoxy, R.sub.2 is hydrogen, hydroxyl, methyl, methoxy, ethoxy, fluorine, chlorine, (alkyl of 1 to 4 carbon atoms)-thio, (alkyl of 1 to 4 carbon atoms)-sulfinyl, (alkyl of 1 to 4 carbon atoms)-sulfonyl, dimethylamino or Z-A-O- where A is alkylene of 2 to 3 carbon atoms, and Z is chlorine, hydroxyl, methylthio, ethylthio, methylsulfinyl; ethylsulfinyl, methylsulfonyl, ethylsulfonyl, methylamino, dimethylamino, diethylamino, phenethylamino, N-methyl-phenethylamino or N-methyl-dimethoxyphenethylamino, R.sub.3 is hydrogen or methoxy, Or any two of R.sub.1, R.sub.2 and R.sub.3 together are methylenedioxy, and R.sub.5 is hydrogen, chlorine or methyl, And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as cardiotonics, anticoagulants and for altering the blood pressure.

  具有异构分子式的化合物##SPC1##，其中R.sub.1是1至4个碳原子的烷氧基，烯丙氧基，苄氧基，甲氧基乙氧基，甲硫基，甲硫醇基，甲磺酰基或甲硫基乙氧基，R.sub.2是氢，羟基，甲基，甲氧基，乙氧基，氟，氯，（1至4个碳原子的烷基）硫基，（1至4个碳原子的烷基）亚砜基，（1至4个碳原子的烷基）磺酰基，二甲基氨基或Z-A-O-其中A是2至3个碳原子的烷基，Z是氯，羟基，甲硫基，乙硫基，甲亚砜基；乙亚砜基，甲磺酰基，乙磺酰基，甲氨基，二甲基氨基，二乙基氨基，苯乙基氨基，N-甲基-苯乙基氨基或N-甲基-二甲氧基苯乙基氨基，R.sub.3是氢或甲氧基，或R.sub.1，R.sub.2和R.sub.3中的任意两个共同为亚甲二氧基，R.sub.5是氢，氯或甲基，以及其非毒性、药理学上可接受的酸盐；这些化合物以及盐可用作心力衰竭药、抗凝剂和改变血压的药物。
• [EN] SMALL MOLECULE INHIBITORS OF VIRAL REPLICATION<br/>[FR] INHIBITEURS À PETITES MOLÉCULES DE RÉPLICATION VIRALE
  申请人：UNIV PRINCETON

  公开号：WO2020231979A1

  公开（公告）日：2020-11-19

  Provided herein are methods involving a compound of the following structural formula: (I) or a pharmaceutically acceptable salt thereof, wherein values for the variables are as described herein. For example, methods for inhibiting replication of a virus, treating a viral infection, inhibiting heat shock protein 90 and treating a heat shock protein 90-mediated disease or condition using a compound of Structural Formula I are provided.
• Ortho lithiation-in situ borylation of substituted morpholine benzamides
  作者：Anna Cederbalk、Morten Lysén、Jan Kehler、Jesper L. Kristensen

  DOI：10.1016/j.tet.2017.02.002

  日期：2017.3

  Morpholine amides are cheap and safe alternative to Weinreb amides as acylating agents of organometallic species. Herein, the in-situ lithiation/borylation of 18 ortho- meta- and para-substituted morpholine benzamides has been investigated. 10 of the 18 substrates provided the desired boronic esters as the major isomer (>90% regioselectivity) in crude isolated yields ranging from 68 to 93%. The synthetic

  吗啉酰胺是Weinreb酰胺作为有机金属物种酰化剂的廉价且安全的替代品。在此，已经研究了18种邻位间和对位取代的吗啉苯甲酰胺的原位锂化/硼化。18种底物中的10种提供了所需的硼酸酯作为主要异构体（> 90％的区域选择性），分离出的粗品收率为68％至93％。随后通过激酶抑制剂的合成说明了此类构件的合成可用性。
• Synthesis of functionalized carbamates and quinones via sequential oxidation of salicylaldehydes using TBHP as the oxidant
  作者：K. Rajendra Prasad、P. Suresh、B. Ravikumar、N. Veera Reddy、K. Rajender Reddy

  DOI：10.1016/j.tetlet.2014.09.080

  日期：2014.11

  A sequential oxidative approach was designed to functionalize salicylaldehyde derivatives and provide corresponding bi-functional amide-carbamate and amide-quinone units. A combination of metal/metal free conditions and TBHP as the external oxidant provided the products in moderate to excellent yields (49-91%). (C) 2014 Elsevier Ltd. All rights reserved.