O³,O⁴-dimethyl-D-mannitol | 17288-98-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: O³,O⁴-dimethyl-D-mannitol
• 英文别名: O³,O⁴-Dimethyl-D-mannit；D-manno-3,4-Dimethoxy-hexan-1,2,5,6-tetraol；3,4-di-O-methyl-D-mannitol；3.4-Di-O-methyl-D-mannitol；3,4-Di-O-methyl-D-mannit；3,4-di-O-methylmannitol；(2R,3R,4R,5R)-3,4-dimethoxyhexane-1,2,5,6-tetrol
• CAS: 17288-98-1
• 化学式: C₈H₁₈O₆
• 分子量: 210.227
• InChiKey: SRZHBUXJTKNDRG-WCTZXXKLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  O³,O⁴-dimethyl-D-mannitol 在 sodium periodate 、 水 作用下， 生成 O²,O³-dimethyl-D-arabinose
  参考文献：
  名称：

  Synthesis and Characterization of 2,3-Di-O-methyl-D-arabinose¹

  摘要：

  DOI：

  10.1021/ja01511a045
• 作为产物：
  描述：

  O¹,O²;O⁵,O⁶-diisopropylidene-O³,O⁴-dimethyl-D-mannitol 在 溶剂黄146 作用下， 以 水 为溶剂， 反应 2.0h， 生成 O³,O⁴-dimethyl-D-mannitol
  参考文献：
  名称：

  Explorations into the Potential of Chiral Sulfonium Reagents to Effect Asymmetric Halonium Additions to Isolated Alkenes

  摘要：

  While methods for the racemic dihalogenation and halohydroxylation of alkenes have been known for decades, enantioselective variants of these processes remain elusive. Initial attempts were made to overcome this long-standing challenge by exploring the potential of chiral, crystalline, sulfur-derived halonium reagents to accomplish the asymmetric dichlorination and iodohydroxylation of 1,2-dihydronaphthalene. Asymmetric dichlorination of this substrate was achieved in 57% yield and 14% enantiomeric excess (ee), but asymmetric iodohydroxylation was much more successful, giving 67% yield and 63% ee. Thorough studies were made of these processes, including investigation of various chiral sulfide derivatives, their substrate scopes, and the reaction conditions.

  DOI：

  10.1055/s-0033-1338865

文献信息

• Linear scaffolds for multivalent targeting of melanocortin receptors
  作者：Dilani Chathurika Dehigaspitiya、Bobbi L. Anglin、Kara R. Smith、Craig S. Weber、Ronald M. Lynch、Eugene A. Mash

  DOI：10.1039/c5ob01779c

  日期：——

  copies of the tetrapeptide His-DPhe-Arg-Trp were attached to scaffolds based on ethylene glycol, glycerol, and D-mannitol by means of the copper-assisted azide–alkyne cyclization. The abilities of these compounds to block binding of a probe at the melanocortin 4 receptor were evaluated using a competitive binding assay. All of the multivalent molecules studied exhibited 30- to 40-fold higher apparent

  通过铜辅助的叠氮化物-炔烃环化作用，将带有1、2、3或4个四肽His - D Phe-Arg-Trp拷贝的分子连接到基于乙二醇，甘油和D-甘露醇的支架上。使用竞争性结合测定法评估了这些化合物阻断探针在黑皮质素4受体上结合的能力。与单价对照相比，所有研究的多价分子均表现出高30至40倍的表观亲和力。这些结果与受体二聚体的二价结合是一致的。没有获得三价或四价结合的证据。与三价或四价结合相反，二价结合所需的配位体间距不同可能是这些结果的原因。
• 1,6-Dimesyl-3,4-dimethyl-D-mannitol and a process for the preparation
  申请人：Gyogyszerkutato Intezet

  公开号：US04235803A1

  公开（公告）日：1980-11-25

  The invention relates to 1,6-dimesyl-3,4-dimethyl-D-mannitol of the formula (I), ##STR1## wherein Ms is mesyl and Me is methyl. This compound is a potent cytostatic agent which can be used to advantage in the therapy of various tumorous diseases. 1,6-Dimesyl-3,4-dimethyl-D-mannitol is prepared according to the invention by subjecting 3,4-dimethyl-D-mannitol to partial mesylation followed by acylation, and splitting off the acyl groups of the resulting compound of the general formula (III), ##STR2## wherein Ms and Me are as defined above and R is a saturated lower aliphatic group, with an acidic alcohol.

  本发明涉及公式（I）的1,6-双甲磺酰-3,4-二甲基-D-甘露醇，其中Ms为甲磺酰，Me为甲基。该化合物是一种有效的细胞毒素，可用于治疗各种肿瘤疾病。根据本发明，通过对3,4-二甲基-D-甘露醇进行部分甲基化后进行酰化，并用酸性醇分离所得化合物的酰基，制备1,6-双甲磺酰-3,4-二甲基-D-甘露醇。化合物的通用公式为（III），其中Ms和Me如上所定义，R为饱和的低级脂肪基。
• POLYSULFATED GLYCOSIDES AND SALTS THEREOF
  申请人：Kuszmann János

  公开号：US20110118198A1

  公开（公告）日：2011-05-19

  The invention relates to polysulfated glycosides of formula (I), the pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions containing these compounds as active ingredients. Furthermore the invention provides a method of preventing, treating or alleviating the symptoms of acute and chronic inflammatory disorders of the airways of mammals—including asthma and asthma-related pathologies.

  本发明涉及公式（I）的多硫酸化糖苷，其药学上可接受的盐，以及包含这些化合物作为活性成分的制药组合物。此外，本发明提供了一种预防、治疗或缓解哺乳动物呼吸道急性和慢性炎症性疾病症状的方法，包括哮喘和哮喘相关病理。
• [EN] POLYSULFATED GLYCOSIDES AND SALTS THEREOF<br/>[FR] GLYCOSIDES POLYSULFATES ET SELS DE CEUX-CI
  申请人：IVAX CORP

  公开号：WO2006017726A3

  公开（公告）日：2006-04-20
• Mercuration of Monoallyl Ethers of Polyols¹
  作者：L. H. Werner、C. R. Scholz

  DOI：10.1021/ja01639a031

  日期：1954.5