1H-吡咯-2,3-二甲酸 | 1125-32-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 中文名称: 1H-吡咯-2,3-二甲酸
• 中文别名: 1H-吡咯-2,3-二羧酸
• 英文名称: 1H-pyrrole-2,3-dicarboxylic acid
• 英文别名: pyrrol-2,3-di-carboxylic acid；pyrrole 2,3-dicarboxylic acid；pyrrole-2,3-dicarboxylic acid；Pyrrol-2,3-dicarbonsaeure；Pyrrol-dicarbonsaeure-2,3
• CAS: 1125-32-2
• 化学式: C₆H₅NO₄
• mdl: MFCD09991931
• 分子量: 155.11
• InChiKey: OEUSNWDYXDEXDR-UHFFFAOYSA-N

物化性质

• 熔点：
  225 °C (decomp)
• 沸点：
  480.7±30.0 °C(Predicted)
• 密度：
  1.671±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  90.4
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 海关编码：
  2933990090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  1H-吡咯-2,3-二甲酸 在 甲醇 、 sodium hydride 作用下， 以 二甲基亚砜 为溶剂， 反应 2.0h， 生成 Dimethyl 1-methyl-1H-pyrrole-2,3-dicarboxylate
  参考文献：
  名称：

  Caffeoylmalic and two pyrrole acids fromParietaria officinalis

  摘要：

  DOI：

  10.1016/0031-9422(90)80203-s
• 作为产物：
  描述：

  pyrrole-2,3-dicarboxylic acid 3-ethyl ester 在 氢氧化钾 作用下， 生成 1H-吡咯-2,3-二甲酸
  参考文献：
  名称：

  Nicolaus; Mangoni, Gazzetta Chimica Italiana, 1956, vol. 86, p. 757,762

  摘要：

  DOI：

文献信息

• Heteroaryl- phenyl heterobicyclic factor Xa inhibitors
  申请人：——

  公开号：US20020119986A1

  公开（公告）日：2002-08-29

  The present application describes heteroaryl-phenyl heterobicycles and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.

  本申请描述了杂芳基苯基杂双环及其衍生物，或其药用盐形式，可作为凝血因子Xa的抑制剂。
• Prodrugs Based on Gemcitabine Structure and Synthetic Methods and Applications Thereof
  申请人：Xue Xiaoxia

  公开号：US20120088908A1

  公开（公告）日：2012-04-12

  Prodrugs based on gemcitabine structure shown in formula (I) as well as their synthetic method and application are disclosed in the present invention, wherein the definitions for the groups of a, b, c, d, E, Z and V are described in the specification. By modifying the N 4 group, the solubility, the bioavailability and the organ specificity of the prodrugs are improved. Therefore, the fast metabolism problem is overcome for the produced prodrugs compounds. Intestinal toxicity induced by gemcitabine is decreased. Thereby, the prodrugs can be delivered by oral administration in clinics and further improve their anti-tumor, anti-cancer, anti-infection and diffusion preventing capability, and can also specifically act on liver or colon. The synthetic method is simple and adapted to industrial production.

  基于吉西他滨结构的前药，如式（I）所示，以及它们的合成方法和应用在本发明中被揭示，其中a、b、c、d、E、Z和V的定义在说明书中描述。通过修改N4基团，改善了前药的溶解性、生物利用度和器官特异性。因此，生产的前药化合物克服了快速代谢问题。吉西他滨引起的肠道毒性减少。因此，前药可以通过口服在临床中投递，并进一步提高其抗肿瘤、抗癌、抗感染和扩散预防能力，还可以特异性地作用于肝脏或结肠。合成方法简单，适用于工业生产。
• MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME
  申请人：TABATA Masayoshi

  公开号：US20110224343A1

  公开（公告）日：2011-09-15

  The present invention provides a modifier for aromatic polyesters which enhances the melt fluidity of aromatic polyesters without a significant decrease in the heat resistance of the aromatic polyesters, and an aromatic polyester resin composition including the modifier for aromatic polyesters. The present invention relates to a modifier for aromatic polyesters comprising polyhydric phenol residues and residues of aromatic polycarboxylic acid, acid halide or acid anhydride thereof, and the modifier comprises a material having a structure composed of a first residue selected from the group consisting of divalent residues represented by Formula (I): —Ar—W 1 x —Ar— and by Formula (II): —Ar—, the first residues being bonded to two identical or different second residues selected from the group consisting of monovalent residues represented by Formula (III): and monovalent residues represented by Formula (IV): —O—C(O)—R 7 —.

  本发明提供了一种用于芳香族聚酯的改性剂，可以增强芳香族聚酯的熔融流动性，而不明显降低芳香族聚酯的耐热性，以及包括该改性剂的芳香族聚酯树脂组合物。本发明涉及一种用于芳香族聚酯的改性剂，包括多羟基酚残基和芳香族多羧酸、酸卤或其酸酐残基，该改性剂包括具有以下结构的材料：第一残基，选择自由式(I)所代表的二价残基：—Ar—W1x—Ar—和自由式(II)所代表的：—Ar—，第一残基与选择自由式(III)所代表的单价残基：和自由式(IV)所代表的单价残基：—O—C(O)—R7—的两个相同或不同的第二残基结合。
• [EN] ELECTROCHEMICAL REDUCTIVE CARBOXYLATION OF UNSATURATED ORGANIC SUBSTRATES IN IONICALLY CONDUCTIVE MEDIUMS<br/>[FR] CARBOXYLATION RÉDUCTRICE ÉLECTROCHIMIQUE DE SUBSTRATS ORGANIQUES INSATURÉS DANS DES MILIEUX CONDUCTEURS D'IONS
  申请人：UNIV MICHIGAN STATE

  公开号：WO2019023532A1

  公开（公告）日：2019-01-31

  The disclosure relates to methods for electrochemical reductive carboxylation of an unsaturated organic substrate to form a dicarboxylic organic product. The unsaturated organic substrate is electrochemically reduced with a carbon dioxide reactant in an ionically conductive, water-immiscible reactant medium to form the dicarboxylic organic product. The dicarboxylic organic product is recovered in an aqueous product medium. Example dicarboxylic organic products include phthalic acid, naphthalenedicarboxylic acid, furan-2,5-dicarboxylic acid, thiophene-2,5-dicarboxylic acid, pyrrole-2,5-dicarboxylic acid, adipic acid, suberic acid, sebacic acid, and 1,12-dodecanedioic acid.

  该披露涉及一种电化学还原羧化方法，用于将不饱和有机底物电化学还原为二羧基有机产物。将不饱和有机底物与二氧化碳反应物在离子导电性、不溶于水的反应介质中进行电化学还原，形成二羧基有机产物。将二羧基有机产物在水性产物介质中回收。示例二羧基有机产物包括邻苯二甲酸、萘二甲酸、呋喃-2,5-二甲酸、噻吩-2,5-二甲酸、吡咯-2,5-二甲酸、己二酸、癸二酸、癸二酸、癸二酸和1,12-十二二酸。
• [EN] NITROGEN CONTAINING HETEROBICYCLES AS FACTOR XA INHIBITORS<br/>[FR] HETEROBICYCLIQUES CONTENANT DE L'AZOTE UTILISES COMME INHIBITEURS DU FACTEUR XA
  申请人：DU PONT PHARM CO

  公开号：WO2000039131A1

  公开（公告）日：2000-07-06

  The present application describes nitrogen containing heterobicyclics and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.

  本申请描述了含氮杂双环及其衍生物，或其药学上可接受的盐形式，它们可用作因子Xa的抑制剂。