Synthesis and Evaluation of a Series of Novel 2-[(4-Chlorophenoxy)methyl]- benzimidazoles as Selective Neuropeptide Y Y1 Receptor Antagonists
作者:Hamideh Zarrinmayeh、Anne M. Nunes、Paul L. Ornstein、Dennis M. Zimmerman、M. Brian Arnold、Douglas A. Schober、Susan L. Gackenheimer、Robert F. Bruns、Philip A. Hipskind、Thomas C. Britton、Buddy E. Cantrell、Donald R. Gehlert
DOI:10.1021/jm9706630
日期:1998.7.1
Methyl substitution was used to probe where substitution on the aromatic ring was best tolerated. In this fashion, the C-4 was chosen for the substitution of the second aminoalkyl functionality. Synthesis of such compounds with a phenoxy tether using the 4-hydroxybenzimidazole 11 was pursued because of their relative ease of synthesis. Functionalization of the hydroxy group of 45 with a series of piperidinylalkyl
合成了一系列从吲哚2衍生出来的新型苯并咪唑(BI),并将其作为选择性神经肽Y(NPY)Y1受体拮抗剂进行评估,目的是开发抗肥胖药。在我们的SAR方法中,C-2处的(4-氯苯氧基)甲基保持恒定,并合成了一系列在N-1处被各种哌啶基烷基取代的BI,以鉴定哌啶环氮相对于N的最佳间距和方向苯并咪唑。发现33中的3-(3-哌啶基)丙基最大程度地增加了对Y1受体的亲和力。由于NPY的Arg33和Arg35与Y1受体结合的至关重要,因此探索了将额外的氨基烷基官能团结合到33的结构中的方法。甲基取代被用来探测芳香环上的取代最能被容忍的地方。以这种方式,选择C-4来取代第二个氨基烷基官能团。由于4-羟基苯并咪唑11的合成相对容易,因此进行了使用苯氧基系链的此类化合物的合成。用一系列哌啶基烷基将45的羟基官能化,得到二元苯并咪唑55-62。其中,BI 56的Ki值为0.0017 microM,是33的Ki的4