1,8-二羟基-2-甲基-9,10-蒽醌 | 34425-60-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 中文名称: 1,8-二羟基-2-甲基-9,10-蒽醌
• 英文名称: 1,8-dihydroxy-2-methylanthraquinone
• 英文别名: isochrysophanol；1,8-dihydroxy-2-methyl-anthraquinone；1,8-Dihydroxy-2-methyl-anthrachinon；1,8-Dihydroxy-2-methylanthrachinon；1,8-dihydroxy-2-methylanthracene-9,10-dione
• CAS: 34425-60-0
• 化学式: C₁₅H₁₀O₄
• 分子量: 254.242
• InChiKey: OGURMTXRUQGVMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,8-二羟基-2-甲基-9,10-蒽醌 、 乙酸酐 在 硫酸 作用下， 生成 1,8-Diacetoxy-2-methyl-anthrachinon
  参考文献：
  名称：

  Eder; Siegfried, Pharmaceutica Acta Helvetiae, 1939, vol. 14, p. 34,69

  摘要：

  DOI：
• 作为产物：
  描述：

  2-bromomethyl-1,8-dimethoxy-9,10-anthracenedione 在 sodium dithionite 、 氢溴酸 作用下， 以 氯仿 、 水 、 溶剂黄146 、 乙腈 为溶剂， 生成 1,8-二羟基-2-甲基-9,10-蒽醌
  参考文献：
  名称：

  Substituent effects upon the peak potentials and reductive cleavage rate constants of hydroxy- and methoxy-substituted 9,10-anthraquinones in 50% aqueous CH3CN: do they correlate?

  摘要：

  A variety of hydroxy- and methoxy-substituted 2-(acetoxymethyl)-9,10-anthraquinones (2a-7a) were reduced electrochemically and with dithionite (S2O-4(2-)) in 50% aqueous CH3CN buffers over a wide pH range. Good to excellent yields of their corresponding reductive cleavage products, the substituted 2-methyl-9,10-anthraquinones 2b-7b, were obtained from most of these anthraquinone acetates, but only at higher pH. Rate constants for the reaction of 2-(acetoxymethyl)-9,10-anthraquinone (1a) with excess dithionite ranged from 1.0 x 10(-4) S-1 at pH values less than 7 to 4.0 x 10(-4) S-1 at a pH of 10, demonstrating that loss of acetate occurs in the rate-determining step and that cleavage occurs slower via the anthrahydroquinone of 1a than the conjugate base of the anthrahydroquinone. Substituent effects upon the reductive cleavage process were determined by measuring rate constants for those acetates that react cleanly with dithionite at pH 8. These effects, which are rationalized on the basis of resonance theory and intramolecular H bonding, correlate fairly well with the peak potentials (E(p)) of the reductive cleavage products of these acetates. Thus, electron-donating substituents on an anthraquinone acetate not only make it more difficult to reduce resulting in a more negative E(p) but also enhance the rate of acetate cleavage in the corresponding anthrahydroquinone.

  DOI：

  10.1021/jo00004a049

文献信息

• Reactions of ketene acetals-14 The use of simple mixed vinylketene acetals in the annulation of quinones
  作者：Jacques Savard、Paul Brassard

  DOI：10.1016/s0040-4020(01)91496-6

  日期：1984.1

  α,β- β, γ-unsaturated esters can be converted by strong base and chlorotrimethylsilane to the corresponding mixed vinylketene acetals which are shown to be particularly useful and generally applicable reagents for the regiospecific annulation of halogenoquinones. The reaction proceeds readily with a variety of substrates including benzoquinones.

  α，β-β，γ-不饱和酯可通过强碱和三甲基氯硅烷转化为相应的混合乙烯酮缩醛，这对于卤代醌的区域特异性环合而言是特别有用和普遍适用的试剂。该反应在包括苯醌在内的多种底物下容易进行。
• Synthesis and Bioactivities of Naturally Occurring Anthraquinones: Isochrysophanol, Isozyganein, ω-Hydroxyisochrysophanol and Morindaparvin
  作者：Javed H. Zaidi、Fazal Naeem、Rashid Iqbal、Mohammed Iqbal Choudhary、Khalid Mohammed Khan、Shahnaz Perveen、Syed T. Ali Shah、Safdar Hayat、Wolfgang Voelter

  DOI：10.1515/znb-2001-0717

  日期：2001.7.1

  Isochrysophanol, isozyganein, ω-hydroxyisochrysophanol, and morindaparvin are naturally occurring substituted anthraquinones. We report the synthesis of these compounds as well as selected biological activities.

  异黄酚、isozyganein、ω-羟基异黄酚和morindaparvin 是天然存在的取代蒽醌。我们报告了这些化合物的合成以及选定的生物活性。
• METHOD FOR MANUFACTURING SUBSTRATE AND METHOD FOR MANUFACTURING LIGHT EMITTING ELEMENT USING SAME
  申请人：Toray Industries, Inc.

  公开号：EP3369780A1

  公开（公告）日：2018-09-05

  The present invention provides a method of producing a substrate on the surface of which the curved surface pattern is carved, using a resin composition that can afford a cured film which can be formed into a resist pattern in curved surface shape, which does not cause resist burning and carbonization even in high-output dry etching processing subject to a high temperature, and which has good etching selectivity and post-etching removability. The present invention is a method of producing a patterned substrate, the method including the steps of: providing, on a substrate, a coating film of a resin composition including (A) an alkali-soluble resin selected from the group consisting of polyimides, polyamideimides, polyimide precursors, polyamideimide precursors, polybenzoxazoles, polybenzoxazole precursors, copolymers of at least two of the resins, and copolymers of at least one of the resins and another structural unit, (B) a photoacid generator, and (C) at least one compound selected from the group consisting of epoxy compounds and oxetane compounds; forming a pattern of the coating film; patterning the substrate through etching using the pattern of the coating film as a mask; and removing the coating film of the resin composition.

  本发明提供了一种在其表面雕刻弧形表面图案的基板的生产方法，该方法使用的树脂组合物可以提供一种固化膜，该固化膜可以形成弧形表面形状的抗蚀剂图案，即使在高温的高输出干蚀刻加工中也不会导致抗蚀剂烧焦和碳化，并且具有良好的蚀刻选择性和蚀刻后可去除性。本发明是一种生产图案化基板的方法，该方法包括以下步骤：在基底上提供一层树脂组合物的涂膜，该树脂组合物包括 (A) 碱溶性树脂，该树脂选自由以下组成的组(A) 至少两种树脂的共聚物，以及至少一种树脂和另一种结构单元的共聚物； (B) 光酸发生器；以及 (C) 至少一种选自由环氧化合物和氧杂环丁烷化合物组成的组中的化合物；形成涂膜图案；使用涂膜图案作为掩膜，通过蚀刻对基底进行图案化；以及去除树脂组合物的涂膜。
• Method for manufacturing substrate and method for manufacturing light emitting element using same
  申请人：TORAY INDUSTRIES, INC.

  公开号：US10418521B2

  公开（公告）日：2019-09-17

  A method of producing a patterned substrate includes the steps of: providing, on a substrate, a coating film of a resin composition including (A) an alkali-soluble resin selected from the group consisting of polyimides, polyamideimides, polyimide precursors, polyamideimide precursors, polybenzoxazoles, polybenzoxazole precursors, copolymers of at least two of the resins, and copolymers of at least one of the resins and another structural unit, (B) a photoacid generator, and (C) at least one compound selected from the group consisting of epoxy compounds and oxetane compounds; forming a pattern of the coating film; patterning the substrate through etching using the pattern of the coating film as a mask; and removing the coating film of the resin composition.

  一种生产图案化基底的方法包括以下步骤在基底上提供一层树脂组合物涂膜，该树脂组合物包括 (A) 碱溶性树脂，该树脂选自由聚酰亚胺、聚酰胺酰亚胺、聚酰亚胺前体、聚酰胺酰亚胺前体、聚苯并恶唑、聚苯并恶唑前体、至少两种树脂的共聚物和至少一种树脂与另一结构单元的共聚物组成的组(A) 至少两种树脂的共聚物，以及至少一种树脂和另一种结构单元的共聚物； (B) 光酸发生器；以及 (C) 至少一种选自由环氧化合物和氧杂环丁烷化合物组成的组中的化合物；形成涂膜图案；使用涂膜图案作为掩膜，通过蚀刻对基底进行图案化；以及去除树脂组合物的涂膜。
• Bioactive extract, fraction of Cassia occidentalis and formulation thereof for bone regeneration
  申请人：COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

  公开号：US11304927B2

  公开（公告）日：2022-04-19

  The present invention relates to a bioactive extract, fraction of Cassia occidentalis and formulation thereof for bone regeneration and treatment of glucocorticoid induced musculo-skeletal diseases and associated electrolyte imbalances.

  本发明涉及一种生物活性提取物、决明子馏分及其制剂，用于骨再生和治疗糖皮质激素诱发的肌肉骨骼疾病及相关的电解质失衡。