Butanedioic acid, hydroxy-, disilver(1+) salt | 90313-71-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: Butanedioic acid, hydroxy-, disilver(1+) salt
• 英文别名: silver L(-)malate；disilver malate；L-malic acid ; disilver L malate；L-Aepfelsaeure; Disilber-L-malat
• CAS: 90313-71-6；106311-08-4
• 化学式: 2Ag*C₄H₄O₅
• 分子量: 347.809
• InChiKey: ANJANNGSLRNEMH-DKWTVANSSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -3.77
• 重原子数：
  10.0
• 可旋转键数：
  3.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  100.49
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  cis-[PtI₂(5,7-di-tert-butyl-1,2,4-triazolo[1,5-a]pyrimidine)₂] 、 Butanedioic acid, hydroxy-, disilver(1+) salt 以 丙酮 为溶剂， 反应 168.0h， 以92%的产率得到cis-[Pt(C₄H₄O₅)(5,7-di-tert-butyl-1,2,4-triazolo[1,5-a]pyrimidine)₂]
  参考文献：
  名称：

  Structure-cytotoxicity relationship for different types of mononuclear platinum(II) complexes with 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine

  摘要：

  To compare the in vitro cytotoxicity of platinum(II) complexes with 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine (dbtp), three complexes were prepared: cis-[PtI2(dbtp)(2)] (1). cis-[Pt(NO3)(2)(dbtP)(2)] (2) and cis-[Pt(C4H4O5)(dbtp)(2)] (3). The coordination compounds have been structurally characterized by IR; H-1, C-13, N-15, Pt-195 NMR and single-crystal X-ray diffraction (1). Spectroscopic studies reveal the monodentate coordination of the heterocycle ligand (dbtp) via N(3) to platinum(II) ions. In addition, the crystal structure of (1) shows that the platinum(II) ion is located in nearly square-planar PtI2N2 environments with two heterocycle ligands (dbtp) arranged in a head-to-head orientation. The complexes have been screened for their cytotoxicity against two human cells: non-small cell lung carcinoma (A549) and breast cancer (T47D). All of the complexes demonstrated a significant antiproliferative activity against both cell lines. On the basis of these results, it is concluded that the cytotoxicity of the studied compounds against T47D follows the order: (3) < (1) < (2). (C) 2012 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.jinorgbio.2012.05.005

文献信息

• Synthesis, Cytotoxicity, Induction of Apoptosis, and Interaction with DNA of Dinuclear Platinum(II) Complexes
  作者：Gang Xu、Chuanzhu Gao、Shaohua Gou、Zhe Cao

  DOI：10.1002/cmdc.201200332

  日期：2012.11

  Six dicarboxylato‐bridged dinuclear platinum(II) complexes S1–S6, with a newly designed chiral ligand, 2‐[(1R,2R)‐2‐aminocyclohexyl]amino}propanoic acid (HL), were prepared and spectrally characterized. The in vitro cytotoxicity of all resulting platinum(II) complexes was evaluated against human HCT‐116, MCF‐7, and HepG‐2 tumor cell lines. The results show that all compounds exhibit positive biological

  制备了六个具有新设计的手性配体2-[（（1 R，2 R）-2-氨基环己基]氨基}丙酸（HL）的二羧基桥连双核铂（II）配合物S1 - S6，并对其进行了光谱表征。评估了所有所得铂（II）配合物对人HCT-116，MCF-7和HepG-2肿瘤细胞系的体外细胞毒性。结果表明，所有化合物均对HCT-116和MCF-7细胞系具有积极的生物学活性，其中的复合物S3，S4和S5，以琥珀酸酯及其衍生物为桥，显示出比阳性对照更好的活性。此外，双染流式细胞术实验表明，目标化合物通过诱导细胞凋亡来抑制肿瘤细胞的生长。凝胶电泳实验证明了该化合物提示pET22b质粒DNA降解的能力几乎与奥沙利铂相同。