6-氨基-4-羟基-己酸 | 102014-43-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 中文名称: 6-氨基-4-羟基-己酸
• 英文名称: 6-amino-4-hydroxy-hexanoic acid
• 英文别名: 6-Amino-4-hydroxy-hexansaeure；6-Amino-4-hydroxyhexanoic acid
• CAS: 102014-43-7
• 化学式: C₆H₁₃NO₃
• mdl: MFCD19205049
• 分子量: 147.174
• InChiKey: HLSZGDRVQUSUIE-UHFFFAOYSA-N

物化性质

• 熔点：
  194 °C
• 沸点：
  364.0±32.0 °C(Predicted)
• 密度：
  1.189±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.4
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  83.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-nitro-4-oxo-hexanoic acid 在 水 、 铂 作用下， 生成 6-氨基-4-羟基-己酸
  参考文献：
  名称：

  Moldenhauer et al., Justus Liebigs Annalen der Chemie, 1953, vol. 583, p. 37,49

  摘要：

  DOI：

文献信息

• Dornow et al., Justus Liebigs Annalen der Chemie, 1954, vol. 588, p. 62,67
  作者：Dornow et al.

  DOI：——

  日期：——
• A HIGH YIELD ROUTE FOR THE PRODUCTION OF COMPOUNDS FROM RENEWABLE SOURCES
  申请人：Zymochem Inc.

  公开号：EP3047030A2

  公开（公告）日：2016-07-27
• MICROORGANISMS AND METHODS FOR THE PRODUCTION OF BIOSYNTHESIZED TARGET PRODUCTS HAVING REDUCED LEVELS OF BYPRODUCTS
  申请人：Genomatica, Inc.

  公开号：EP3314002A1

  公开（公告）日：2018-05-02
• HIGH YIELD ROUTE FOR THE PRODUCTION OF COMPOUNDS FROM RENEWABLE SOURCES
  申请人：ZYMOCHEM INC.

  公开号：US20170044551A1

  公开（公告）日：2017-02-16

  Provided herein are methods, compositions, and non-naturally occurring microbial organism for preparing compounds such as 1-butanol, butyric acid, succinic acid, 1,4-butanediol, 1-pentanol, pentanoic acid, glutaric acid, 1,5-pentanediol, 1-hexanol, hexanoic acid, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, ε-Caprolactone, 6-amino-hexanoic acid, ε-Caprolactam, hexamethylenediamine, linear fatty acids and linear fatty alcohols that are between 7-25 carbons long, linear alkanes and linear α-alkenes that are between 6-24 carbons long, sebacic acid and dodecanedioic acid comprising: a) converting a C N aldehyde and pyruvate to a C N+3 β-hydroxyketone intermediate through an aldol addition; and b) converting the C N+3 β-hydroxyketone intermediate to the compounds through enzymatic steps, or a combination of enzymatic and chemical steps.
• HIGH YIELD ROUTE FOR THE PRODUCTION OF 1, 6-HEXANEDIOL
  申请人：ZYMOCHEM, INC.

  公开号：US20200255840A1

  公开（公告）日：2020-08-13

  Provided herein are methods, compositions, and non-naturally occurring microbial organism for preparing compounds such as 1-butanol, butyric acid, succinic acid, 1,4-butanediol, 1-pentanol, pentanoic acid, glutaric acid, 1,5-pentanediol, 1-hexanol, hexanoic acid, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, ε-Caprolactone, 6-amino-hexanoic acid, ε-Caprolactam, hexamethylenediamine, linear fatty acids and linear fatty alcohols that are between 7-25 carbons long, linear alkanes and linear α-alkenes that are between 6-24 carbons long, sebacic acid and dodecanedioic acid comprising: a) converting a C N aldehyde and pyruvate to a C N+3 β-hydroxyketone intermediate through an aldol addition; and b) converting the C N+3 β-hydroxyketone intermediate to the compounds through enzymatic steps, or a combination of enzymatic and chemical steps.