[(2R)-1-oxaspiro[2.4]heptan-2-yl]methanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 英文名称: [(2R)-1-oxaspiro[2.4]heptan-2-yl]methanol
• 化学式: C₇H₁₂O₂
• 分子量: 128.171
• InChiKey: YBFNAIRUPOFXGX-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  cyclopentylidenacetaldehyde 在 sodium tetrahydroborate 、 C₂₄H₃₃NOSi 作用下， 以 甲醇 、 水 为溶剂， 反应 48.67h， 生成 [(2R)-1-oxaspiro[2.4]heptan-2-yl]methanol 、 [(2S)-1-oxaspiro[2.4]heptan-2-yl]methanol
  参考文献：
  名称：

  Asymmetric epoxidation of α,β-unsaturated aldehydes catalyzed by a spiro-pyrrolidine-derived organocatalyst

  摘要：

  The asymmetric epoxidation of alpha,beta-unsaturated aldehydes, catalyzed by a spiro-pyrrolidine (SPD)-derived organocatalyst, has been accomplished with good diastereoselectivities (up to dr >20:1) and with high to excellent enantioselectivities (up to 99% ee). (C) 2016 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2016.02.009

文献信息

• Asymmetric epoxidation of α,β-unsaturated aldehydes catalyzed by a spiro-pyrrolidine-derived organocatalyst
  作者：Ming-Hui Xu、Yong-Qiang Tu、Jin-Miao Tian、Fu-Min Zhang、Shao-Hua Wang、Shi-Heng Zhang、Xiao-Ming Zhang

  DOI：10.1016/j.tetasy.2016.02.009

  日期：2016.4

  The asymmetric epoxidation of alpha,beta-unsaturated aldehydes, catalyzed by a spiro-pyrrolidine (SPD)-derived organocatalyst, has been accomplished with good diastereoselectivities (up to dr >20:1) and with high to excellent enantioselectivities (up to 99% ee). (C) 2016 Elsevier Ltd. All rights reserved.