Trifluoromethylpyrroloindole carboxylic ester derivatives represented by general formulae (1) and (2) having an antitumor activity, optically active isomers thereof, and pharmacologically acceptable salts thereof, wherein R represents lower alkyl; R¹ represents an α-amino acid residue, etc.; R² represents hydrogen, a hydroxyl-protecting group, etc.; and Y represents halogen, arylsulfonyloxy, etc.
通式(1)和(2)代表的具有抗肿瘤活性的三
氟甲基
吡咯吲哚羧酸酯衍
生物、其光学活性异构体及其药理上可接受的盐,其中R代表低级烷基;R¹代表
α-氨基酸残基等;R²代表氢、羟基保护基等;Y代表卤素、芳基磺酰氧基等。