Acetic acid (5S,7R,8S,9S,10R)-8,9-diacetoxy-7-acetoxymethyl-3-naphthalen-2-yl-1,6-dioxa-4-thia-2-aza-spiro[4.5]dec-2-en-10-yl ester | 854603-00-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Acetic acid (5S,7R,8S,9S,10R)-8,9-diacetoxy-7-acetoxymethyl-3-naphthalen-2-yl-1,6-dioxa-4-thia-2-aza-spiro[4.5]dec-2-en-10-yl ester
• CAS: 854603-00-2
• 化学式: C₂₅H₂₅NO₁₀S
• 分子量: 531.54
• InChiKey: MBBRCIVGGOBUFQ-JAWPICGBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.68
• 重原子数：
  37.0
• 可旋转键数：
  6.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  136.02
• 氢给体数：
  0.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  Acetic acid (5S,7R,8S,9S,10R)-8,9-diacetoxy-7-acetoxymethyl-3-naphthalen-2-yl-1,6-dioxa-4-thia-2-aza-spiro[4.5]dec-2-en-10-yl ester 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 0.42h， 以72%的产率得到(5S,6R,7S,8R,9R)-9-(hydroxymethyl)-3-naphthalen-2-yl-1,10-dioxa-4-thia-2-azaspiro[4.5]dec-2-ene-6,7,8-triol
  参考文献：
  名称：

  β-d-Galactopyranosyl-thiohydroximates and d-galactopyranosylidene-spiro-oxathiazoles: synthesis and enzymatic evaluation against E. colid-galactosidase

  摘要：

  By reaction with arylhydroximoyl chlorides, 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-galactopyranose was converted to the corresponding beta-D-galactopyranosyl-thiohydroximates, which gave predominantly (1S)-D-galactopyranosylidene-spiro-oxathiazoles on illumination in the presence of NBS. Conventional O-deacetylation of both thiohydroximates and oxathiazoles gave weak inhibitors of E. coli D-galactosidase (K-i 1.1-11.1 mM). (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2005.02.021
• 作为产物：
  描述：

  2,3,4,6-四-O-乙酰基-1-硫代-BETA-D-吡喃半乳糖 在 N-溴代丁二酰亚胺(NBS) 、 三乙胺 作用下， 以 二氯甲烷 、 氯仿 为溶剂， 反应 1.25h， 生成 Acetic acid (5S,7R,8S,9S,10R)-8,9-diacetoxy-7-acetoxymethyl-3-naphthalen-2-yl-1,6-dioxa-4-thia-2-aza-spiro[4.5]dec-2-en-10-yl ester
  参考文献：
  名称：

  β-d-Galactopyranosyl-thiohydroximates and d-galactopyranosylidene-spiro-oxathiazoles: synthesis and enzymatic evaluation against E. colid-galactosidase

  摘要：

  By reaction with arylhydroximoyl chlorides, 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-galactopyranose was converted to the corresponding beta-D-galactopyranosyl-thiohydroximates, which gave predominantly (1S)-D-galactopyranosylidene-spiro-oxathiazoles on illumination in the presence of NBS. Conventional O-deacetylation of both thiohydroximates and oxathiazoles gave weak inhibitors of E. coli D-galactosidase (K-i 1.1-11.1 mM). (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2005.02.021