2-(1,3-benzodioxol-5-yl)-2-methylpropan-1-ol | 80854-18-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 2-(1,3-benzodioxol-5-yl)-2-methylpropan-1-ol
• 英文别名: 2-(3,4-methylenedioxyphenyl)-2-methylpropyl alcohol；2,2-Dimethyl-2-(3,4-methylenedioxyphenyl)ethanol
• CAS: 80854-18-8
• 化学式: C₁₁H₁₄O₃
• 分子量: 194.23
• InChiKey: PPGNSVHWVIRQLC-UHFFFAOYSA-N

物化性质

• 沸点：
  293.7±29.0 °C(Predicted)
• 密度：
  1.178±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(1,3-benzodioxol-5-yl)-2-methylpropan-1-ol 在 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 以71%的产率得到2-(1,3-benzodioxol-5-yl)-2-methylpropanal
  参考文献：
  名称：

  SUBSTITUTED CATHECHOLS AS INHIBITORS OF IL-4 AND IL-5 FOR THE TREATMENT BRONCHIAL ASTHMA

  摘要：

  本发明涉及通式1的化合物，用于通过抑制IL-4或IL-5途径的抑制治疗支气管哮喘。本发明还涉及使用通式1的化合物通过抑制IL-4或IL-5途径的抑制治疗支气管哮喘。本发明还涉及通过口服、鼻内、或吸入途径向需要治疗的哺乳动物给予化合物或所述组合物来抑制IL-4或IL-5途径以治疗哮喘的方法。通式1的化合物可用于减少周围血管和支气管炎症。

  公开号：

  US20140135393A1
• 作为产物：
  描述：

  苯并[1,3]二氧代l-5-乙酸甲酯 在 lithium aluminium tetrahydride 、 正丁基锂 、 二异丙胺 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 生成 2-(1,3-benzodioxol-5-yl)-2-methylpropan-1-ol
  参考文献：
  名称：

  SUBSTITUTED CATHECHOLS AS INHIBITORS OF IL-4 AND IL-5 FOR THE TREATMENT BRONCHIAL ASTHMA

  摘要：

  本发明涉及通式1的化合物，用于通过抑制IL-4或IL-5途径的抑制治疗支气管哮喘。本发明还涉及使用通式1的化合物通过抑制IL-4或IL-5途径的抑制治疗支气管哮喘。本发明还涉及通过口服、鼻内、或吸入途径向需要治疗的哺乳动物给予化合物或所述组合物来抑制IL-4或IL-5途径以治疗哮喘的方法。通式1的化合物可用于减少周围血管和支气管炎症。

  公开号：

  US20140135393A1

文献信息

• [EN] INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE (PI3) AND INDUCERS OF NITRIC OXIDE (NO)<br/>[FR] INHIBITEURS DE LA PHOSPHATIDYLINOSITOL-3-KINASE (PI3) ET INDUCTEURS D'OXYDE NITRIQUE (NO)
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2010079423A1

  公开（公告）日：2010-07-15

  The present invention relates to compounds of general formula 1 for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention also relates to the use of compound of general formula 1 for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention further relates to a method of treating malignancy by inhibition of PI3-Akt pathway and or induction of NO by administration of compound or said composition to a mammal in need thereof.

  本发明涉及通式1的化合物，通过抑制PI3-Akt通路和/或诱导NO来治疗恶性肿瘤。本发明还涉及使用通式1的化合物通过抑制PI3-Akt通路和/或诱导NO来治疗恶性肿瘤。本发明还涉及通过向需要该治疗的哺乳动物给予该化合物或该组合物来抑制PI3-Akt通路和/或诱导NO治疗恶性肿瘤的方法。
• 2-Arylpropyl ether or thioether derivatives and insecticidal and
  申请人：Mitsuitoatsu Chemicals Inc.

  公开号：US04397864A1

  公开（公告）日：1983-08-09

  The present invention relates to 2-arylpropyl ether or thioether derivatives represented by the following general formula [I]: ##STR1## wherein Ar stands for an aryl group, R stands for a methyl or ethyl group, Y stands for an oxygen or sulfur atom, and B stands for a group represented by the following formula [II]: ##STR2## or the following general formula [III]: ##STR3## wherein Z stands for an oxygen or sulfur atom or a carbonyl or methylene group, R.sup.1 stands for a hydrogen or halogen atom or a lower alkyl group or a lower alkoxy group, and n is an integer of from 1 to 5 with the proviso that when n is 2 or more, the groups R.sup.1 may be the same or different, and also to processes for the preparation or these ethers of thioethers and a use of these ethers or thioethers. These compounds of the present invention have excellent insecticidal and acaricidal activities while the toxicity of these compounds are very low.

  本发明涉及以下一般式[I]所代表的2-芳基丙基醚或硫醚衍生物：其中Ar代表芳基基团，R代表甲基或乙基基团，Y代表氧原子或硫原子，B代表以下式[II]所代表的基团：或以下一般式[III]所代表的基团：其中Z代表氧原子或硫原子或羰基或亚甲基基团，R1代表氢原子或卤素原子或低碳基或低烷氧基，n为1至5的整数，但当n为2或更多时，基团R1可以相同或不同。本发明还涉及制备这些醚或硫醚的方法以及这些醚或硫醚的用途。这些化合物具有优异的杀虫和杀螨活性，而这些化合物的毒性非常低。
• Process for the preparation of 2-arylpropyl ether or thioether
  申请人：Mitsuitoatsu Chemicals Inc.

  公开号：US04570005A1

  公开（公告）日：1986-02-11

  2-Arylpropyl ether or thioether derivatives represented by the following general formula [I]: ##STR1## wherein Ar stands for an aryl group, R stands for a methyl or ethyl group, Y stands for an oxygen or sulfur atom, and B stands for a group represented by the following formula [II]: ##STR2## or the following general formula [III]: ##STR3## wherein Z stands for an oxygen or sulfur atom or a carbonyl or methylene group, R.sup.1 stands for a hydrogen or halogen atom or a lower alkyl group or a lower alkoxy group, and n is an integer of from 1 to 5 with the proviso that when n is 2 or more, the groups R.sup.1 may be the same or different, are produced by reacting a compound represented by the following formula (V): ##STR4## with a compound represented by the following formula (VI): B--CH.sub.2 --D (VI) wherein Ar, R and B are defined above, A is a halogen atom and D is Y--H in which Y is as defined above, in the presence of a base in dimethylsulfoxide or sulfolane. The compounds thus prepared have excellent insecticidal and acaricidal activities while the toxicity of these compounds are very low.

  以下是2-芳基丙基醚或硫醚衍生物的通式[I]：##STR1##其中Ar代表芳基，R代表甲基或乙基，Y代表氧原子或硫原子，B代表以下通式[II]所代表的基团：##STR2##或以下通式[III]的通式：##STR3##其中Z代表氧原子或硫原子或羰基或亚甲基基团，R.sup.1代表氢原子或卤素原子或较低的烷基基团或较低的烷氧基基团，n是1到5之间的整数，但当n为2或更多时，基团R.sup.1可以相同或不同。这些衍生物是通过将以下通式(V)所代表的化合物与以下通式(VI)所代表的化合物反应而制备的：##STR4##其中Ar，R和B如上所定义，A是卤素原子，D是Y-H，其中Y如上所定义，在二甲基亚砜或硫代乙醇中，在碱的存在下。这样制备的化合物具有优异的杀虫和杀螨活性，而这些化合物的毒性非常低。
• 2-aryl-ethyl ether derivatives and insecticidal and acaricidal agents
  申请人：Mitsuitoatsu Chemicals, Inc.

  公开号：US04599362A1

  公开（公告）日：1986-07-08

  The present invention relates to 2-arylethyl ether or thioether derivatives represented by the following general formula [I]: ##STR1## wherein Ar stands for an aryl group, R.sup.1 stands for straight or branched chain alkyl group of 1 to 6 carbons, R.sup.2 stands for a hydrogen atom, or a methyl or ethyl group, R.sup.3 stands for a halogen atom, or a methyl or methoxyl group, R.sup.4 stands for a hydrogen or halogen atom, or a lower alkyl or lower alkoxy group, and n is an integer of 1 or 2 with the proviso that when n is 2, the groups R.sup.4 may be the same or different, and Y stands for an oxygen or sulfur atom, and also to processes for the preparation of these ethers or thioethers and a use of these ethers or thioethers. These compounds of the present invention have excellent insecticidal and acaricidal activities while the toxicity of these compounds are very low.

  本发明涉及由下列通式[I]表示的2-芳基乙基醚或硫醚衍生物：其中Ar代表芳基基团，R1代表1至6个碳的直链或支链烷基，R2代表氢原子，或甲基或乙基基团，R3代表卤原子，或甲基或甲氧基，R4代表氢或卤原子，或较低的烷基或烷氧基，n是1或2的整数，但当n为2时，基团R4可以相同或不同，Y代表氧或硫原子。本发明还涉及制备这些醚或硫醚的过程以及这些醚或硫醚的用途。这些化合物具有优异的杀虫和杀螨活性，而这些化合物的毒性非常低。
• INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE (PI3) AND INDUCERS OF NITRIC OXIDE (NO)
  申请人：Bandyopadhyay Santu

  公开号：US20120190738A1

  公开（公告）日：2012-07-26

  The present invention relates to compounds of general formula I for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention also relates to the use of compound of general formula I for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention further relates to a method of treating malignancy by inhibition of PI3-Akt pathway and or induction of NO by administration of compound or said composition to a mammal in need thereof.

  本发明涉及一般式I的化合物，通过抑制PI3-Akt途径和/或诱导NO治疗恶性肿瘤。本发明还涉及使用一般式I的化合物通过抑制PI3-Akt途径和/或诱导NO治疗恶性肿瘤。本发明还涉及一种通过向需要该治疗的哺乳动物给予化合物或所述组合物来抑制PI3-Akt途径和/或诱导NO治疗恶性肿瘤的方法。