Pyrano[3,2-h][1,4]benzodioxin-9-one | 123373-38-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: Pyrano[3,2-h][1,4]benzodioxin-9-one
• CAS: 123373-38-6
• 化学式: C₁₁H₆O₄
• 分子量: 202.166
• InChiKey: RHUOZTFIUQTDRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  formyl-6 hydroxy-5 benzodioxanne-1,4 在 N-溴代丁二酰亚胺(NBS) 、 过氧化氢苯甲酰 、 sodium iodide 作用下， 以 四氯化碳 、 丙酮 、 甲苯 为溶剂， 反应 21.0h， 生成 Pyrano[3,2-h][1,4]benzodioxin-9-one
  参考文献：
  名称：

  Guillaumet, Gerald; Hretani, Mohamed; Coudert, Gerard, Journal of Heterocyclic Chemistry, 1989, vol. 26, p. 193 - 197

  摘要：

  DOI：

文献信息

• GUILLAUMET, GERALD;HRETANI, MOHAMED;COUDERT, GERARD, J. HETEROCYCL. CHEM., 26,(1989) N, C. 193-197
  作者：GUILLAUMET, GERALD、HRETANI, MOHAMED、COUDERT, GERARD

  DOI：——

  日期：——
• IMMUNOMODULATORY PHARMACEUTICAL COMPOSITION CONTAINING A COMBINATION OF THREE COUMARINOLIGNOIDS
  申请人：Council of Scientific and Industrial Research

  公开号：EP1968575A2

  公开（公告）日：2008-09-17
• Immunomodulatory pharmaceutical composition and a process for preparation thereof
  申请人：Khanuja Preet Singh Suman

  公开号：US20070258989A1

  公开（公告）日：2007-11-08

  The present invention provides a novel pharmaceutical composition consisting of a combination of three coumarinolignoids of formula 1, 2 and 3 isolated from the seeds of the plant Cleome viscose along with a pharmaceutically acceptable carrier useful as a immunomodulator. The invention also describes the ability of the compounds to modulate humorral and cell mediated immune response. It further provides a process for the preparation of a novel pharmaceutical composition of the said three coumarinolignoids in an optimized ratio to modulate humorral and cell mediated immune response.
• IMMUNOMODULATORY PHARMACEUTICAL COMPOSITION AND A PROCESS FOR PREPARATION THEREOF
  申请人：Khanuja Suman Preet Singh

  公开号：US20110092585A1

  公开（公告）日：2011-04-21

  The present invention provides a novel pharmaceutical composition consisting of a combination of three coumarinolignoids of formula 1, 2 and 3 isolated from the seeds of the plant Cleome viscosa along with a pharmaceutically acceptable carrier useful as a immunomodulator. The invention also describes the ability of the compounds to modulate humorral and cell mediated immune response. It further provides a process for the preparation of a novel pharmaceutical composition of the said three coumarinolignoids in an optimized ratio to modulate humorral and cell mediated immune response.
• [EN] IMMUNOMODULATORY PHARMACEUTICAL COMPOSITION AND A PROCESS FOR PREPARATION THEREOF<br/>[FR] COMPOSITION PHARMACEUTIQUE IMMUNOMODULATRICE ET SON PROCEDE DE PREPARATION
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2007066197A2

  公开（公告）日：2007-06-14

  [EN] The present invention provides a novel pharmaceutical composition consisting of a combination of three coumarinolignoids of formula 1, 2 and 3 isolated from the seeds of the plant Cleome viscose along with a pharmaceutically acceptable carrier useful as a immunomodulator. The invention also describes the ability of the compounds to modulate humorral and cell mediated immune response. It further provides a process for the preparation of a novel pharmaceutical composition of the said three coumarinolignoids in an optimized ratio to modulate humorral and cell mediated immune response.
  [FR] La présente invention concerne une composition pharmaceutique innovante consistant en une combinaison de trois coumarino-lignoïdes de formule 1, 2 et 3, isolés des graines d'une plante, le Cleome viscose, accompagnés d'un support pharmaceutiquement acceptable, utile en tant qu'immunomodulateur. L'invention concerne également la capacité des composés à moduler la réponse immunitaire à médiation humorale et à médiation cellulaire. Elle concerne en outre un procédé de préparation d'une composition pharmaceutique innovante des trois coumarino-lignoïdes en question dans un rapport optimisé pour moduler la réponse immunitaire à médiation humorale et à médiation cellulaire.