Acetic acid;butane-1,4-diamine | 146716-66-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Acetic acid;butane-1,4-diamine
• 英文别名: acetic acid;butane-1,4-diamine
• CAS: 146716-66-7
• 化学式: 2C₂H₄O₂*C₄H₁₂N₂
• 分子量: 208.258
• InChiKey: BBZCJTGNQONLOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.23
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  89.3
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5,8-二甲氧基-3,4-二氢-1H-2-萘酮 、 Acetic acid;butane-1,4-diamine 在 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 24.0h， 生成 N,N'-bis(5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthyl)tetramethylenediamine
  参考文献：
  名称：

  Perez; Rosell; Mauleon, Il Farmaco, 1991, vol. 46, # 10, p. 1155 - 1166

  摘要：

  DOI：

文献信息

• Modified polynucleotides for use in RNA interference
  申请人：Dharmacon, Inc.

  公开号：EP2261334A2

  公开（公告）日：2010-12-15

  Methods and compositions for performing RNA interference comprising a wide variety of stabilized siRNAs suitable for use in serum-containing media and for in vivo applications, such as therapeutic applications, are provided. These siRNAs permit effective and efficient applications of RNA interference to applications such as diagnostics and therapeutics through the use of one or more modifications including orthoesters, terminal conjugates, modified linkages and 2'-modified nucleotides. Uniquely modified siRNAs have been developed that reduce off-target effects incurred in gene-silencing. The modifications include: phosphorylation of the first 5' terminal antisense nucleotide; 2' carbon modifications of the first and second or first, second, and third 5' terminal antisense nucleotides; and optionally 2' carbon modifications of the first and second or first, second, and third 5' terminal sense nucleotide. Control and exaequo molecules are also provided. siRNA molecules and related control, trackability and exaequo agents with specific stability modifications were developed.

  本发明提供了进行 RNA 干扰的方法和组合物，其中包括适合在含血清介质中使用和用于体内应用（如治疗应用）的各种稳定 siRNA。这些 siRNA 通过使用一种或多种修饰（包括正酯、末端共轭物、修饰连接和 2'- 修饰核苷酸），可将 RNA 干扰有效、高效地应用于诊断和治疗等领域。已开发出的独特修饰 siRNA 可减少基因沉默过程中产生的脱靶效应。这些修饰包括：第一个 5'末端反义核苷酸的磷酸化；第一个和第二个或第一个、第二个和第三个 5'末端反义核苷酸的 2'碳修饰；以及第一个和第二个或第一个、第二个和第三个 5'末端有义核苷酸的 2'碳修饰。此外，还提供了具有特定稳定性修饰的 siRNA 分子及相关的控制、可追踪性和 exaequo 剂。
• Stabilized polynucleotides for use in RNA interference
  申请人：Dharmacon, Inc.

  公开号：US20040198640A1

  公开（公告）日：2004-10-07

  Methods and compositions for performing RNA interference comprising a wide variety of stabilized polynucleotides suitable for use in serum-containing media and for in vivo applications, such as therapeutic applications, are provided. These polynucleotides permit effective and efficient applications of RNA interference to applications such as diagnostics and therapeutics through the use of one or more modifications including orthoesters, terminal conjugates, modified linkages and 2′modified nucleotides.

  本发明提供了进行 RNA 干扰的方法和组合物，其中包括适合在含血清介质中使用和用于体内应用（如治疗应用）的各种稳定化多核苷酸。这些多核苷酸通过使用一种或多种修饰，包括正酯、末端共轭物、修饰连接和 2′修饰核苷酸，可将 RNA 干扰有效、高效地应用于诊断和治疗等领域。
• siRNA induced systemic gene silencing in mammalian systems
  申请人：Dharmacon Inc.

  公开号：US20040224405A1

  公开（公告）日：2004-11-11

  The present invention is directed to methods and compositions for performing gene silencing in mammalian cells by targeting a region of a non-protein coding target nucleic acid sequence with at least one siRNA molecule comprising a duplex region of between 19 and 30 base pairs.

  本发明涉及在哺乳动物细胞中进行基因沉默的方法和组合物，其方法是用至少一个 siRNA 分子靶向非蛋白编码靶核酸序列的一个区域，该 siRNA 分子包括 19 至 30 个碱基对的双链区。
• [EN] METHODS TO DETECT A FUNGAL CELL<br/>[FR] PROCÉDÉS POUR DÉTECTER UNE CELLULE FONGIQUE
  申请人：UNIV NEW JERSEY MED

  公开号：WO2013169932A3

  公开（公告）日：2014-01-03
• A NOVEL TRAPPING SYSTEM FOR FRUIT FLIES
  申请人：THE UNITED STATES OF AMERICA, represented by THE SECRETARY OF THE DEPARTMENT OF AGRICULTURE

  公开号：EP0758194A1

  公开（公告）日：1997-02-19