N-[2-[2-[2-[2-[2,5-dioxo-3,4-bis(phenylsulfanyl)pyrrol-1-yl]ethoxy]ethoxy]ethoxy]ethyl]-2-[2-oxo-2-[4-[3-oxo-3-(2-oxoazetidin-1-yl)propyl]anilino]ethoxy]acetamide | 1415920-60-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: N-[2-[2-[2-[2-[2,5-dioxo-3,4-bis(phenylsulfanyl)pyrrol-1-yl]ethoxy]ethoxy]ethoxy]ethyl]-2-[2-oxo-2-[4-[3-oxo-3-(2-oxoazetidin-1-yl)propyl]anilino]ethoxy]acetamide
• CAS: 1415920-60-3
• 化学式: C₄₀H₄₄N₄O₁₀S₂
• 分子量: 804.942
• InChiKey: TWKHFXYXZXVWDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  56
• 可旋转键数：
  24
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  221
• 氢给体数：
  2
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  3-(4-硝基苯基)丙酸 在 盐酸 、 正丁基锂 、 氯化亚砜 、 新戊醇 、 偶氮二甲酸二异丙酯 、 palladium on activated charcoal 、 氢气 、 N,N-二异丙基乙胺 、 三苯基膦 、 N,N'-二异丙基碳二亚胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 生成 N-[2-[2-[2-[2-[2,5-dioxo-3,4-bis(phenylsulfanyl)pyrrol-1-yl]ethoxy]ethoxy]ethoxy]ethyl]-2-[2-oxo-2-[4-[3-oxo-3-(2-oxoazetidin-1-yl)propyl]anilino]ethoxy]acetamide
  参考文献：
  名称：

  Development of a long acting human growth hormone analog suitable for once a week dosing

  摘要：

  Human growth hormone was conjugated to a carrier aldolase antibody, using a novel linker by connecting a disulphide bond in growth hormone to a lysine-94 amine located on the Fab arm of the antibody. The resulting CovX body showed reduced affinity towards human growth hormone receptor, reduced cell-based activity, but improved pharmacodynamic properties. We have demonstrated that this CovX-body, given once a week, showed comparable activity as growth hormone given daily in an in vivo hypophysectomized rat model. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.11.104

文献信息

• Development of a long acting human growth hormone analog suitable for once a week dosing
  作者：Moorthy S.S. Palanki、Abhijit Bhat、Ben Bolanos、Florence Brunel、Joselyn Del Rosario、Danielle Dettling、Mark Horn、Rodney Lappe、Ryan Preston、Annette Sievers、Nebojsa Stankovic、Gary Woodnut、Gang Chen

  DOI：10.1016/j.bmcl.2012.11.104

  日期：2013.1

  Human growth hormone was conjugated to a carrier aldolase antibody, using a novel linker by connecting a disulphide bond in growth hormone to a lysine-94 amine located on the Fab arm of the antibody. The resulting CovX body showed reduced affinity towards human growth hormone receptor, reduced cell-based activity, but improved pharmacodynamic properties. We have demonstrated that this CovX-body, given once a week, showed comparable activity as growth hormone given daily in an in vivo hypophysectomized rat model. (c) 2012 Elsevier Ltd. All rights reserved.