(S)-3-(2-aminophenyl)-4-phenyloxazolidin-2-one | 1407767-20-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-3-(2-aminophenyl)-4-phenyloxazolidin-2-one
• CAS: 1407767-20-7
• 化学式: C₁₅H₁₄N₂O₂
• 分子量: 254.288
• InChiKey: ALCLXALAPPOANH-CQSZACIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.97
• 重原子数：
  19.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  55.56
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (S)-3-(2-aminophenyl)-4-phenyloxazolidin-2-one 、 2-二苯基膦苯甲醛 在 zinc(II) chloride 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以65%的产率得到
  参考文献：
  名称：

  ‘Evans Auxiliary' Based P-N Ligands for Pd-Catalyzed Asymmetric Allylic Alkylation Reactions

  摘要：

  A new type of chiral P-N ligands has been prepared which incorporates the Evans auxiliary as chiral ligand. They were found to act as effective ligands in the Pd-catalyzed allylic alkylation reactions. Using these ligands with allylpalladium chloride dimer as catalyst, the coupling of 1,3-diphenyl-3-acetoxyprop-1-ene and dimethyl malonate proceeded smoothly at -10 degrees C providing the desired product with enantiomeric excess up to 87% and excellent yield.

  DOI：

  10.1055/s-0031-1290404
• 作为产物：
  描述：

  1-氟-2-硝基苯 在 30% Pd/C 、 氢气 、 sodium hydride 作用下， 以 甲醇 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 生成 (S)-3-(2-aminophenyl)-4-phenyloxazolidin-2-one
  参考文献：
  名称：

  ‘Evans Auxiliary' Based P-N Ligands for Pd-Catalyzed Asymmetric Allylic Alkylation Reactions

  摘要：

  A new type of chiral P-N ligands has been prepared which incorporates the Evans auxiliary as chiral ligand. They were found to act as effective ligands in the Pd-catalyzed allylic alkylation reactions. Using these ligands with allylpalladium chloride dimer as catalyst, the coupling of 1,3-diphenyl-3-acetoxyprop-1-ene and dimethyl malonate proceeded smoothly at -10 degrees C providing the desired product with enantiomeric excess up to 87% and excellent yield.

  DOI：

  10.1055/s-0031-1290404