diethyl 2,2'-(((6-(dimethylamino)-8-methoxy-4-(piperidin-1-yl)quinolin-2-yl)methyl)azanediyl)diacetate | 1443040-45-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: diethyl 2,2'-(((6-(dimethylamino)-8-methoxy-4-(piperidin-1-yl)quinolin-2-yl)methyl)azanediyl)diacetate
• CAS: 1443040-45-6
• 化学式: C₂₆H₃₈N₄O₅
• 分子量: 486.612
• InChiKey: JOSQMCNGZWYUEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.23
• 重原子数：
  35.0
• 可旋转键数：
  11.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  84.44
• 氢给体数：
  0.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  diethyl 2,2'-(((6-(dimethylamino)-8-methoxy-4-(piperidin-1-yl)quinolin-2-yl)methyl)azanediyl)diacetate 、 C.I.酸性橙108 以 乙腈 为溶剂， 反应 10.0h， 以48%的产率得到2,2'-(((6-(dimethylamino)-8-methoxy-4-(piperidin-1-yl)quinolin-2-yl)methyl)azanediyl)bis(N-(2-hydroxyethyl)acetamide)
  参考文献：
  名称：

  Design of quinoline-based fluorescent probe for the ratiometric detection of cadmium in aqueous media

  摘要：

  A new fluorescent probe, DQCd2, based on 4-piperidinoquinoline has been synthesized as a fluorescent probe for Cd2+. It can ratiometrically respond to Cd2+ in PBS buffer by a remarkable emission intensity enhancement (88-fold) and wavelength shift (70 nm). (C) 2013 Lin Xue and Hua Jiang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.04.002
• 作为产物：
  描述：

  (6-(dimethylamino)-8-methoxy-4-(piperidin-1-yl)quinolin-2-yl)methanol 在 氯化亚砜 、 potassium carbonate 、 potassium iodide 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 11.0h， 生成 diethyl 2,2'-(((6-(dimethylamino)-8-methoxy-4-(piperidin-1-yl)quinolin-2-yl)methyl)azanediyl)diacetate
  参考文献：
  名称：

  Design of quinoline-based fluorescent probe for the ratiometric detection of cadmium in aqueous media

  摘要：

  A new fluorescent probe, DQCd2, based on 4-piperidinoquinoline has been synthesized as a fluorescent probe for Cd2+. It can ratiometrically respond to Cd2+ in PBS buffer by a remarkable emission intensity enhancement (88-fold) and wavelength shift (70 nm). (C) 2013 Lin Xue and Hua Jiang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.04.002