2,6-bis(N-trimellitimido)-4-trifluoromethyl-40-phenoxydiphenyl ether | 1374879-16-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-bis(N-trimellitimido)-4-trifluoromethyl-40-phenoxydiphenyl ether
• CAS: 1374879-16-9
• 化学式: C₃₇H₁₉F₃N₂O₁₀
• 分子量: 708.56
• InChiKey: HFBIUAGIBIHCGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.29
• 重原子数：
  52.0
• 可旋转键数：
  8.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  167.82
• 氢给体数：
  2.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  2,6-bis(N-trimellitimido)-4-trifluoromethyl-40-phenoxydiphenyl ether 在 茴香硫醚 、 水 、 1,2-乙二硫醇 、 三氟乙酸 、 苯酚 作用下， 反应 3.0h， 生成 [D-Gln13]des-acyl-ghrelin-(6-13)
  参考文献：
  名称：

  Des-Acyl Ghrelin Fragments and Analogues Promote Survival of Pancreatic β-Cells and Human Pancreatic Islets and Prevent Diabetes in Streptozotocin-Treated Rats

  摘要：

  Des-acyl ghrelin, although devoid of binding to ghrelin receptor (GRLN), exerts many biological effects, including regulation of glucose and lipid metabolism. Indeed, des-acyl ghrelin promotes pancreatic beta-cell and human islet cell survival and prevents diabetes in streptozotocin (STZ) treated rats. We investigated whether des-acyl ghrelin fragments excluding serine(3), which is essential for binding to GRLN, would display similar actions. Among the different compounds tested, des-acyl ghrelin((6-13)) and des-acyl ghrelin((6-13)) with alanine substitutions or cyclization, but not with D-amino acid substitutions, showed the best survival effect, similar to des-acyl ghrelin. Des-acyl ghrelin((6-13)) even prevented diabetes in STZ-treated rats and protected human circulating angiogenic cells from oxidative stress and senescence, similar to des-acyl ghrelin. These results suggest that not only full-length des-acyl ghrelin but also short des-acyl ghrelin fragments have clear beneficial effects on several tissues in vitro and in vivo.

  DOI：

  10.1021/jm201223m
• 作为产物：
  描述：

  4-苯氧基苯酚 在 palladium 10% on activated carbon 、 potassium carbonate 、 溶剂黄146 、 肼 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 23.17h， 生成 2,6-bis(N-trimellitimido)-4-trifluoromethyl-40-phenoxydiphenyl ether
  参考文献：
  名称：

  Fluoro-containing poly(amide-imide)s with sterically hindered pendants: Synthesis and characterization

  摘要：

  A structurally kinked fluorinated diacid, 2,6-bis(N-trimellitimido)-4-trifluoromethyl-4'-phenoxydiphenyl ether (TFPDPE) was synthesized and then used for preparing a new class of fluoro-containing poly(amide-imide)s via phosphorylation polyamidation with four diamines including 4,4'-(oxidianiline, 2,6-diamino-4-trifluoromethyl)-4'-phenoxydiphenyl ether, 1,5-bis(2-amino4-trifluoromethylphenoxy)-naphthalene, and 2,2'-bis(2-amino-4-trifluoromethylphenoxy)-1,1'-binaphthyl. Chemical structure of monomer TFPDPE as well as the resulted polymers was fully confirmed by IR and NMR spectroscopy. Limited viscosity numbers ([eta]'s) of the resulting polymers at 25 degrees C were measured. The values of (M) over bar (w) and (M) over bar (n) were determined using gel-permeation chromatography (GPC). In addition, the absorption edge values (lambda(0)) obtained from their UV curves were determined, and all the resulting poly(amide-imide)s exhibited high optical transparency. The crystallinity of the polymers was estimated by wide-angle X-ray diffraction (WXRD), and the resulted polymers exhibited nearly an amorphous nature. To study on the surface morphologies, the scanning electron microscopy (SEM) images of the poly(amide-imide)s were taken. Furthermore, solubility of the samples in various kinds of organic solvents was tested. From differential scanning calorimetric (DSC) analyses, the polymers showed Tg's between 304 and 328 degrees C. Thermo-stability of the polymers was determined by thermogravimetric analysis (TGA), and the 10% weight loss temperatures of the poly(amide-imide)s were found to be in the range of 548-553 degrees C. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2012.03.009