苯并[g][1]苯并呋喃-3-酮 | 58645-78-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 中文名称: 苯并[g][1]苯并呋喃-3-酮
• 英文名称: naphtho<1,2-a>-1H-furan-3-one
• 英文别名: naphtho[1,2-b]furan-3-one；Naphtho[1,2-b]furan-3-on；naphtho[1,2-b]furan-3 (2H)-one；naphtho[1,2-b]furan-3-one；6.7-Benzo-cumaranon-(3)；naphtho[1,2-b]furan-3(2H)-one；benzo[g][1]benzofuran-3-one
• CAS: 58645-78-6
• 化学式: C₁₂H₈O₂
• 分子量: 184.194
• InChiKey: DHQCVZQASJMVEQ-UHFFFAOYSA-N

物化性质

• 熔点：
  118-119 °C
• 沸点：
  366.8±22.0 °C(Predicted)
• 密度：
  1.313±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  苯并[g][1]苯并呋喃-3-酮 在 sodium hydride 、 potassium carbonate 作用下， 以 丙酮 、 苯 为溶剂， 反应 4.33h， 生成 Methoxy-3 naphto<1,2-b>furannecarboxylate-2 de methyle
  参考文献：
  名称：

  Einhorn, Jacques; Demerseman,Pierre; Royer Rene, Journal of Heterocyclic Chemistry, 1985, vol. 22, p. 1243 - 1247

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(萘-1-基氧基)乙酰氯 在 三氯化铝 作用下， 以 苯 为溶剂， 反应 1.0h， 生成 苯并[g][1]苯并呋喃-3-酮
  参考文献：
  名称：

  Bicyclic N-Hydroxyurea Inhibitors of 5-Lipoxygenase:  Pharmacodynamic, Pharmacokinetic, and in Vitro Metabolic Studies Characterizing N-Hydroxy-N-(2,3-dihydro-6-(phenylmethoxy)-3-benzofuranyl)urea

  摘要：

  A series of N-hydroxyurea derivatives have been prepared and examined as inhibitors of 5-lipoxygenase. Oral activity was established by examining the inhibition of LTB(4) biosynthesis in an ex vivo assay in the mouse. The pharmacodynamic performance in the mouse of selected compounds was assessed using an ex vivo LTB(4) assay and an adoptive peritoneal anaphylaxis assay at extended pretreat times. Compounds with an extended duration of action were reexamined as the individual enantiomers in the ex vivo assay, and the (S) enantiomer of N-hydroxy-N-[2,3-dihydro-6-(phenylmethoxy)-3-benzofuranyl]urea, (+)-1a (SE 202235), was selected as the compound with the best overall profile. Higher plasma concentrations and longer plasma half-lives were found for (+)-1a relative to its enantiomer in the mouse, monkey, and dog. In vitro metabolic studies in mouse liver microsomes established enantiospecific glucuronidation as a likely mechanism for the observed differences between the enantiomers of la. Enantioselective glucuronidation favoring (-)-1a was also found in human liver microsomes.

  DOI：

  10.1021/jm960271d

文献信息

• Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use
  申请人：Venkatesan Mudumbai Aranapakam

  公开号：US20050004162A1

  公开（公告）日：2005-01-06

  3-Piperidin-4-yl-1H-indole and 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole derivatives are disclosed. Methods of using the derivatives and compositions containing the derivatives in the prevention and/or treatment of serotonin disorders, such as depression and anxiety, are also disclosed. Additionally, processes for the preparation of 3-piperidin-4-yl-1H-indole and 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole derivatives are disclosed.

  3-哌啶基-1H-吲哚和3-(1,2,3,6-四氢吡啶-4-基)-1H-吲哚衍生物已被披露。还披露了使用这些衍生物以及含有这些衍生物的组合物在预防和/或治疗血清素紊乱，如抑郁症和焦虑症方面的方法。此外，还披露了制备3-哌啶基-1H-吲哚和3-(1,2,3,6-四氢吡啶-4-基)-1H-吲哚衍生物的方法。
• Lipoxygenase inhibitors
  申请人：SmithKline Beecham Corporation

  公开号：US05140047A1

  公开（公告）日：1992-08-18

  Tricyclic hydroxyurea and hydroxamate compounds, pharmaceutical compositions, and their use as as inhibitors of the oxidation of polyunsaturated fatty acids, such as by inhibition on the 5-lipoxygenase enzyme, and treatment of diseases therein.

  三环羟基脲和羟酸酯化合物，制药组合物及其用作抑制多不饱和脂肪酸氧化的抑制剂，例如通过抑制5-脂氧酶酶的作用，并用于治疗相关疾病。
• PIPERIDINYL INDOLE AND TETROHYDROPYRIDINYL INDOLE DERIVATIVES AND METHODS OF THEIR USE
  申请人：Venkatesan Mudumbai Aranapakam

  公开号：US20070225319A1

  公开（公告）日：2007-09-27

  3-Piperidin-4-yl-1H-indole and 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole derivatives are disclosed. Methods of using the derivatives and compositions containing the derivatives in the prevention and/or treatment of serotonin disorders, such as depression and anxiety, are also disclosed. Additionally, processes for the preparation of 3-piperidin-4-yl-1H-indole and 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole derivatives are disclosed.

  本发明揭示了3-哌啶基-1H-吲哚和3-(1,2,3,6-四氢-吡啶-4-基)-1H-吲哚衍生物。本发明还揭示了使用这些衍生物和含有这些衍生物的组合物在预防和/或治疗血清素紊乱，如抑郁症和焦虑症方面的方法。此外，本发明还揭示了制备3-哌啶基-1H-吲哚和3-(1,2,3,6-四氢-吡啶-4-基)-1H-吲哚衍生物的过程。
• Catalyst-Controlled Selectivity Switch in Three-Component Reaction: An NHC-Catalyzed Strategy for the Synthesis of δ-Lactone-Fused Spirobenzofuran-3-ones
  作者：Zhanyong Wang、Ting Yang、Dongfang Liu、Rongxiang Chen、Nan Wang、Hong Liu、Jiarong Li、Kaikai Wang、Hongxin Liu

  DOI：10.3390/molecules27185952

  日期：——

  An efficient, three-component reaction of aldehydes and benzofuran-3-ones was developed. This process provides a new approach for the preparation of synthetically and biologically important spirobenzofuran-3-one derivatives with moderate-to-good yields under mild conditions. A switch of intramolecular to intermolecular domino Michael–aldol–lactonization leading to differential product formation was

  开发了醛和苯并呋喃-3-酮的高效三组分反应。该方法为在温和条件下制备具有中等至良好收率的合成和生物学重要的螺苯并呋喃-3-酮衍生物提供了一种新方法。通过不同的 NHC 催化，实现了分子内多米诺骨牌迈克尔-醇醛-内酯化作用向分子间多米诺骨牌的转变，从而导致不同的产物形成。
• Photocurable coating composition, and overprint and process for producing same
  申请人：FUJIFILM Corporation

  公开号：EP2042563A1

  公开（公告）日：2009-04-01

  A photocurable coating composition is provided that includes (A) a compound represented by Formula (I) below, (B) a photopolymerization initiator, and (C) a compound having an ethylenically unsaturated bond. (In Formula (I), X denotes O, S, or NR, n denotes an integer of 0 to 4, R denotes a hydrogen atom, an alkyl group, or an acyl group, R1 to R8 independently denote a hydrogen atom or a monovalent substituent, and R1 to R4 may form a ring in which two thereof that are adjacent are bonded to each other.) There are also provided an overprint having on an electrophotographically printed material an overprint layer in which the photocurable coating composition is photocured, and a process for producing the overprint that includes a step of obtaining an electrophotographically printed material by carrying out electrophotographic printing on a printing substrate, a step of coating the electrophotographically printed material with the photocurable coating composition, and a step of photocuring the photocurable coating composition.

  光固化涂料组合物包括 (A) 下式 (I) 所代表的化合物、(B) 光聚合引发剂和 (C) 具有乙烯不饱和键的化合物。 (在式(I)中，X 表示 O、S 或 NR，n 表示 0 至 4 的整数，R 表示氢原子、烷基或酰基，R1 至 R8 独立地表示氢原子或单价取代基，R1 至 R4 可形成其中相邻的两个相互键合的环)。 还提供了一种罩印，其在电致发光印刷材料上具有罩印层，在罩印层中光固化了光固化涂层组合物，还提供了一种生产罩印的工艺，该工艺包括通过在印刷基底上进行电致发光印刷获得电致发光印刷材料的步骤、在电致发光印刷材料上涂布光固化涂层组合物的步骤，以及对光固化涂层组合物进行光固化的步骤。