Alkenes can be stereoselectively arylated and vinylated without transition-metal catalyst under mild conditions through an interesting NBS-promoted semipinacol rearrangement and a subsequent unusual NaOH-mediated Grob fragmentation.
通过有趣的
NBS促进的半
频哪醇重排以及随后的异常NaOH介导的Grob裂解,烯烃可以在温和的条件下进行立体选择性芳基化和
乙烯基化,而无需使用过渡
金属催化剂。