2-Aethyl-4-oxo-buttersaeure | 89599-36-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Aethyl-4-oxo-buttersaeure
• 英文别名: 2-<2-Oxo-aethyl>-buttersaeure；2-ethyl-4-oxo-butyric acid；2-Ethyl-4-oxobutanoic acid
• CAS: 89599-36-0
• 化学式: C₆H₁₀O₃
• mdl: MFCD19228516
• 分子量: 130.144
• InChiKey: LNSPMOHJLXEULR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  盐酸 、 2-Aethyl-4-oxo-buttersaeure 生成 2-Aethyl-4-oxo-buttersaeure-aethylester 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Carriere, Annales de Chimie (Cachan, France), 1922, vol. <9> 17, p. 122

  摘要：

  DOI：
• 作为产物：
  描述：

  2-ethyl-3-formyl-succinic acid diethyl ester 在 盐酸 、 sodium ethanolate 作用下， 生成 2-Aethyl-4-oxo-buttersaeure
  参考文献：
  名称：

  Schtschukina; Preobrashenski, Zhurnal Obshchei Khimii, 1940, vol. 10, p. 1367

  摘要：

  DOI：

文献信息

• [EN] DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS<br/>[FR] COMPOSÉS DE DIHYDROPYRIMIDINE ET LEUR APPLICATION DANS DES PRODUITS PHARMACEUTIQUES
  申请人：SUNSHINE LAKE PHARMA CO LTD

  公开号：WO2014029193A1

  公开（公告）日：2014-02-27

  Provided herein are dihydropyrimidine compounds and their pharmaceutical　applications, especially for use in treating and preventing HBV diseases. Specifically,provided herein are compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein the variables of the formulas are as defined in the specification. Also provided herein is the use of the compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof for treating and preventing HBV diseases.

  本文提供了二氢嘧啶化合物及其药物应用，特别是用于治疗和预防HBV疾病。具体而言，本文提供了具有化学式(I)或(Ia)的化合物，或其对映体、对二构体、互变异构体、水合物、溶剂合物或其药学上可接受的盐，其中化合物的变量如规范中所定义。本文还提供了使用具有化学式(I)或(Ia)的化合物，或其对映体、对二构体、互变异构体、水合物、溶剂合物或其药学上可接受的盐用于治疗和预防HBV疾病。
• Method of manufacture of 1,3-oxathiolane nucleosides
  申请人：GILEAD SCIENCES, INC.

  公开号：EP1535921A1

  公开（公告）日：2005-06-01

  Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base. Using the processes described herein, the compounds can be provided as isolated enantiomers.

  提供了制备1,3-氧硫杂环嘧啶核苷的过程，其中包括制备1,3-氧硫杂环环的高效方法以及将1,3-氧硫杂环与嘧啶或嘌呤碱基进行后续缩合的方法。使用本文所述的过程，可以提供单体对映体化合物。
• [EN] METHOD OF MANUFACTURE OF 1,3-OXATHIOLANE NUCLEOSIDES<br/>[FR] METHODE DE PRODUCTION DE NUCLEOSIDES DE 1,3-OXATHIOLANE
  申请人：TRIANGLE PHARMACEUTICALS INC

  公开号：WO2000009494A1

  公开（公告）日：2000-02-24

  Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base. Using the processes described herein, the compounds can be provided as isolated enantiomers.

  提供了制备1,3-氧硫杂环核苷的过程，其中包括制备1,3-氧硫杂环环的高效方法以及将1,3-氧硫杂环与嘧啶或嘌呤碱基进行缩合的后续步骤。使用本文所描述的过程，这些化合物可以作为分离的对映体提供。
• Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents
  申请人：Farina Carlo

  公开号：US20070027137A1

  公开（公告）日：2007-02-01

  Described herein are new bicyclic arylimidazolones having nootropic action (i.e., protecting and stimulating cerebral functions), analgesic action and anti hyperalgesic action; also described is the process for their preparation and pharmaceutical compositions comprising them, useful for the treatment of cognitive deficits, and of various types of pain.

  本文介绍了一种具有神经保护和刺激脑功能、镇痛作用和抗高痛敏作用的新型双环芳基咪唑酮；还描述了它们的制备过程和包含它们的制药组合物，用于治疗认知缺陷和各种类型的疼痛。
• Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof
  申请人：Farina Carlo

  公开号：US20100173945A1

  公开（公告）日：2010-07-08

  Described herein are new bicyclic arylimidazolones having nootropic action (i.e., protecting and stimulating cerebral functions), analgesic action and anti hyperalgesic action; also described is the process for their preparation and pharmaceutical compositions comprising them, useful for the treatment of cognitive deficits, and of various types of pain.

  本文介绍了一种新的双环芳基咪唑酮，具有促进和保护大脑功能的诺普利特作用，镇痛作用和抗高敏作用；还介绍了它们的制备过程和包含它们的制药组合物，用于治疗认知缺陷和各种类型的疼痛。