4-ethyl-1-methyl itaconate | 71428-22-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-ethyl-1-methyl itaconate
• 英文别名: 4-Ethyl-1-methyl-2-methylensuccinat；4-O-ethyl 1-O-methyl 2-methylidenebutanedioate
• CAS: 71428-22-3
• 化学式: C₈H₁₂O₄
• 分子量: 172.181
• InChiKey: QSSQDVQKBZEBNP-UHFFFAOYSA-N

物化性质

• 沸点：
  120-121 °C(Press: 13 Torr)
• 密度：
  1.1354 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-ethyl-1-methyl itaconate 、 2-溴-1-环己烯-1-甲醛 在 palladium diacetate 、 三苯基膦 sodium acetate 作用下， 以 四氢呋喃 为溶剂， 反应 20.0h， 以49%的产率得到2-ethyl 3-methyl 5,6,7,8-tetrahydronaphthalene-2,3-dicarboxylate
  参考文献：
  名称：

  钯催化烯烃对β-溴乙烯基醛的芳构化

  摘要：

  容易从酮和PBr 3 / DMF / CHCl 3中获得的β-溴乙烯基醛在催化量的钯催化剂和碱存在下，在125°C下用适当的吸电子基团取代的烯烃在THF中芳构化。

  DOI：

  10.1016/j.tet.2005.08.001
• 作为产物：
  描述：

  (1S,2S,4R)-2-Ethoxycarbonylmethyl-7-isopropylidene-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester 以 甲苯 为溶剂， 生成 4-ethyl-1-methyl itaconate
  参考文献：
  名称：

  A Facile Synthesis of Methyl 2-Alkyl-2-alkenoates

  摘要：

  DOI：

  10.1055/s-1979-28736

文献信息

• [EN] QUINAZOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER<br/>[FR] DERIVES QUINAZOLINE, UTILISATIONS DE CES DERNIERS DANS LE TRAITEMENT DU CANCER
  申请人：ASTRAZENECA AB

  公开号：WO2004096226A1

  公开（公告）日：2004-11-11

  The invention concerns quinazoline derivatives of the formula: (I); wherein X1, Q1, Z, R1, R2, Y, a and m are as defined in the description, which are erbB tyrosine kinase inhibitors, particularly EGFR tyrosine kinase inhibitors. Also claimed are processes for their preparation; pharmaceutical compositions containing them; and their use as therapeutic agents in the treatment of erbB tyrosine kinase mediated diseases such as cancer.

  该发明涉及喹唑啉衍生物的公式(I)；其中X1、Q1、Z、R1、R2、Y、a和m如描述中定义，它们是erbB酪氨酸激酶抑制剂，特别是EGFR酪氨酸激酶抑制剂。还要求保护它们的制备方法；含有它们的药物组合物；以及它们作为治疗剂在治疗erbB酪氨酸激酶介导的疾病如癌症中的应用。
• Methyl 4-oxothiolane-3-carboxylate and methyl 2-methyl-4-oxothiolane-3-carboxylate anions as synthetic equivalents of α-acrylate and α-crotonate anions. Formal synthesis of integerrinecic acid
  作者：Pier Giovanni Baraldi、Mario Guarneri、Gian Pierp Pollini、Daniele Simoni、Achilla Barco、Simonetta Benetti

  DOI：10.1039/p19840002501

  日期：——

  (8a–e) of methyl 4-oxothiolane-3-carboxylate (4) and methyl 2-methyl-4-oxothiolane-3-carboxylate (5) gave good yields of the α-substituted acrylates (7a–h) and α-substituted crotonates (9a–e); thus the corresponding heterocyclic anions (1a) and (1b) could be considered to be synthetic equivalents of α-acrylate and α-crotonate anions respectively. A formal synthesis of integerrinecic acid (10) is reported

  碱促成的4-氧代硫杂环戊烷-3-羧酸甲酯（4）和2-甲基-4-氧代硫杂环戊烯-3-羧酸甲酯（5）的C烷基化产物（6a - h）和（8a - e）的断裂使α-取代的丙烯酸酯（7a - h）和α-取代的巴豆酸酯（9a - e）具有良好的收率；因此，相应的杂环阴离子（1a）和（1b）可以分别视为α-丙烯酸酯和α-巴豆酸根阴离子的合成等价物。甲萘甲酸的正式合成（10），表明了该策略在天然产物化学中的有用性。
• A novel α-acrylate anion equivalent: a useful synthon for α-substituted acrylic esters
  作者：Pier Giovanni Baraldi、Achille Barco、Simonetta Benetti、Fabio Moroder、Gian Piero Pollini、Daniele Simoni、Vinicio Zanirato

  DOI：10.1039/c39820001265

  日期：——

  An effiecient preparation of α-substituted acrylic esters is described based on the Dieckmann–Michael retrograde reactions of the C-alkylation product of 4-methoxycarbonylthiolan-3-one (1).

  基于4-甲氧基羰基噻喃-3-酮（1）的C-烷基化产物的Dieckmann-Michael逆反应，描述了一种有效的α-取代丙烯酸酯的制备方法。
• ACTIVE ENERGY RAY-CURABLE RESIN COMPOSITION, MANUFACTURING METHOD FOR ACTIVE ENERGY RAY-CURABLE RESIN COMPOSITION, COATING MATERIAL, COATING FILM, AND FILM
  申请人：DIC Corporation

  公开号：US20150361293A1

  公开（公告）日：2015-12-17

  Provided are a coating with good blocking resistance, transparency, and scratch resistance, a laminated film including such a coating, an active-energy-radiation-curable resin composition, and a method for manufacturing such a resin composition. The laminated film includes a coating layer and a plastic film layer. The coating layer is made of a resin composition containing, as essential components, fine inorganic particles (A) and a resin component (b) in a mass ratio [(A)/(b)] of 30/70 to 60/40. The coating has an arithmetic mean roughness (Ra) of 1 to 30 nm and a haze of 1.4 or less for a thickness of 100 μm or less.

  提供了一种具有良好阻塞抗性、透明性和耐刮擦性的涂层、包括这样一种涂层的层压膜、一种活性能量辐射固化树脂组合物以及一种制造这样的树脂组合物的方法。层压膜包括涂层层和塑料膜层。涂层层由含有精细无机颗粒(A)和树脂成分(b)的树脂组合物制成，其中(A)/(b)的质量比为30/70至60/40。对于100μm或更薄的厚度，涂层的算术平均粗糙度(Ra)为1至30nm，混浊度为1.4或更低。
• Process for producing alpha, beta-unsaturated carboxylic acid esters and catalyst for use in such process
  申请人：Nippon Shokubai Co., Ltd.

  公开号：EP1123915A1

  公开（公告）日：2001-08-16

  Economical and efficient processes for producing an α, β-unsaturated carboxylic acid heterocycle-inserted ester and an α,β-unsaturated carboxylic acid polyheteroalkylene ester as well as a catalyst suited for use in economically and efficiently producing an α,β-unsaturated carboxylic acid ester are provided. The invention provides (1) a process for producing an α,β-unsaturated carboxylic acid ester which comprises reacting an α,β-unsaturated carboxylic acid ester with a heterocyclic compound, (2) a process for producing an α,β-unsaturated carboxylic acid ester which comprises reacting an α,β-unsaturated carboxylic acid with a heterocyclic compound in the presence of a polymerization inhibitor and a metal oxide catalyst, and (3) a catalyst for the production of an α,β-unsaturated carboxylic acid ester    comprising a metal oxide.

  本发明提供了经济、高效地生产α，β-不饱和羧酸杂环插入酯和α，β-不饱和羧酸聚异链烷烃酯的工艺，以及适用于经济、高效地生产α，β-不饱和羧酸酯的催化剂。 本发明提供 (1）一种生产α，β-不饱和羧酸酯的工艺，它包括使α，β-不饱和羧酸酯与杂环化合物反应、 (2) α，β-不饱和羧酸酯的生产工艺 其中包括使 α，β-不饱和羧酸与杂环化合物反应 在聚合抑制剂和金属氧化物催化剂存在下，以及 (3) α,β-不饱和羧酸酯生产催化剂 包括一种金属氧化物。