4-(4'-aminobenzyl)benzoic acid | 10099-39-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4'-aminobenzyl)benzoic acid
• 英文别名: 4-(4-amino-benzyl)-benzoic acid；4-(4-Amino-benzyl)-benzoesaeure；4-(4'-Aminobenzyl)benzoesaeure；4-[(4-Aminophenyl)methyl]benzoic acid
• CAS: 10099-39-5
• 化学式: C₁₄H₁₃NO₂
• 分子量: 227.263
• InChiKey: KACYBLNWLGHEGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(4'-aminobenzyl)benzoic acid 在 sodium hydroxide 、 sodium azide 、 三乙胺 作用下， 以 1,4-二氧六环 、 水 、 丙酮 、 甲苯 为溶剂， 反应 21.0h， 生成 4-{4'-[(tert-butyloxycarbonyl)amino]benzyl}phenylisocyanate
  参考文献：
  名称：

  Synthesis, Characterization, and Solvolysis of Mono- and Bis-S-(glutathionyl) Adducts of Methylene-bis-(phenylisocyanate) (MDI)

  摘要：

  Bifunctional isocyanates are highly reactive compounds that undergo nucleophilic attack by a variety of functional groups available in the biological system. While the etiology of the respiratory disease caused by diisocyanates is not fully understood, a great deal of research has been performed to elucidate the chemical mechanisms involved in the direct and indirect effects of these compounds. Since adducts of isocyanates are found not only to proteins along the entire respiratory tree but also to proteins in the circulatory system, it is likely that a transport mechanism for the isocyanate from the respiratory to the circulatory system exists. The initial reaction of isocyanates with cellular thiols to form thiocarbamates, which are known to release the isocyanate under physiological conditions, is believed to provide a possible carrier mechanism for the isocyanate functional group. Previous work with aliphatic mono-isocyanates and the aromatic diisocyanate toluene diisocyanate has demonstrated the feasibility of this mechanisin. Adding to this database, the products of the reaction of the highly water-insoluble, low vapor pressure, methylene-bis-(phenylisocyanate) (MDI) with glutathione were synthesized, and their chemical stability under various pH and buffer conditions was tested. Novel synthetic routes were developed for both the mono- and bis-S-(glutathionyl) adducts with MDI that yielded each compound in analytically pure form. Both compounds were found to be unstable under mild basic conditions (phosphate-buffered saline, pH 7.4, and NaHCO3, pH 8.2), however to a different degree. Furthermore, a significant influence of the pH value (the rate of degradation increases with pH) and the concentration of free glutathione (increasing thiol stabilizes the adduct) on the stability was observed, indicating a base-catalyzed mechanism of the degradation/formation of the thiocarbamate bond. Unlike the monoadduct, which forms almost exclusively the polyurea upon degradation, a variety of products were formed upon degradation of the his adduct. Though the disappearance of the his adduct was complete as measured by HPLC, H-1 NMR spectra showed the existence of residual thiocarbamate bonds in the final mixture. In both cases, no evidence of the free methylene-bis-phenylamine (MDA) could be detected under the applicable conditions.

  DOI：

  10.1021/tx0255020
• 作为产物：
  描述：

  4-(苯基甲基)苯甲酸 在 ammonium hydroxide 、 硫化氢 、 硝酸 作用下， 生成 4-(4'-aminobenzyl)benzoic acid
  参考文献：
  名称：

  Colonge; Fichet, Bulletin de la Societe Chimique de France, 1955, p. 412,414

  摘要：

  DOI：

文献信息

• Thermoplastic polyamideimide copolymers and method of preparation
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0017422A1

  公开（公告）日：1980-10-15

  Thermoplastic polyamideimide copolymers are provided which are excellent in both heat stability and melt viscosity characteristics at a temperature of from about 300°C to about 400°C. The copolymers of the invention comprise Units A of the formula in an amount of about 50 mole %, Units B of the formula in an amount of about 15-48 mole % and Units C of the formula in an amount of about 35-2 mole %, wherein Z is a trivalent aromatic group having two of its three carbonyl groups attached to adjacent carbon atoms, a is 0 or 1, b is 0,1,2,3 or 4, R1 is alkyl (C1-4), R2 is selected from alkyl (C1-4), halo and nitro, c is an integer from 1 to 25 and X is chosen from - SO2 -CO- or -C(CH3)2-. The copolymers may be made by reacting diamines containing the Units B and C respectively, e.g. I and II, with trimellitic acid (or another aromatic tribasic carboxylic acid with two carboxyl groups attached to adjacent carbon atoms) in an organic polar solvent using a dehydrating catalyst - or alternatively the diamines may be reacted with the acid anhydride acid chloride using a hydrochloride scavenger, subsequently closing the ring of the polyamide-amic acid thus formed.

  本发明提供的热塑性聚酰胺酰亚胺共聚物在约 300°C 至约 400°C 的温度条件下，热稳定性和熔融粘度特性都非常出色。 本发明的共聚物包含式中的单元 A，其含量约为 50 摩尔%；式中的单元 B，其含量约为 50 摩尔%。 约 50 摩尔%，式中单元 B 含量约为 15-48 摩尔%，以及式中的单元 C 其中 Z 是三价芳香基团，其三个羰基中的两个与相邻碳原子相连；a 是 0 或 1；b 是 0、1、2、3 或 4；R1 是烷基（C1-4）；R2 选自烷基（C1-4）、卤代和硝基；c 是 1 至 25 的整数；X 选自-SO2-CO-或-C(CH3)2-。共聚物的制造方法是：使用脱水催化剂，在有机极性溶剂中，将分别含有单元 B 和单元 C 的二胺（如 I 和 II）与偏苯三酸（或另一种在相邻碳原子上连接有两个羧基的芳香族三元羧酸）反应，或者使用盐酸盐清除剂，将二胺与酸酐酰氯反应，然后封闭由此形成的聚酰胺-氨基甲酸酯环。
• Amorphous aromatic copolyamide, a process for the preparation thereof, and shaped objects
  申请人：AKZO N.V.

  公开号：EP0239159A1

  公开（公告）日：1987-09-30

  An amorphous, injection-mouldable copolyamide comprising linear chains of each of the units having the formulae: (I) -CO-Ar-CO-, (II) -NH-Ar-CO-, and (III) -NH-Ar-CO-, wherein Ar represents one or more optionally substituted arylene radicals selected from the group consisting of (1) para oriented arylene, (2) meta oriented arylene, (3) arylene-X-arylene, wherein X is -C(Y)(H)-, -O-, -S-, -SO₂- or -CO-, with Y is H or C₁-₄-alkyl, and (4) arylene-CZZ′-arylene, wherein Z,Z′ are alkyl or cycloalkyl, provided that at least one of the units of the formulae (I), (II) or (III) are arylene radicals from more than one of the groups (1), (2), (3) and (4). Said units are preferably present in a molar ratio of 17-41.5% of (I), 17-41.5% of (II) and 17-66% of (III).

  一种无定形、可注射成型的共聚多酰胺，由具有以下式子的各单元的线性链组成： (I) -CO-Ar-CO-、 (II) -NH-Ar-CO-, 和 (III) -NH-Ar-CO- 、 其中 Ar 代表一个或多个任选取代的芳烯基，选自以下组成的组 (1) 对位定向芳基、 (2) 对位芳基 (3) 芳烯-X-芳基，其中 X 是-C(Y)(H)-、-O-、-S-、-SO₂- 或-CO-，Y 是 H 或 C₁-₄ 烷基，以及 (4) 芳烯-CZZ′-芳基，其中 Z、Z′为烷基或环烷基、 条件是式 (I)、(II) 或 (III) 的单元中至少有一个是来自 (1)、(2)、(3) 和 (4) 中一个以上基团的芳基。上述单元的摩尔比最好为（I）的 17-41.5%、（II）的 17-41.5%和（III）的 17-66%。
• Polyester copolymer and process for the production of the same
  申请人：BRIDGESTONE CORPORATION

  公开号：EP0571095A2

  公开（公告）日：1993-11-24

  A polyester copolymer having an aromatic amine incorporated in the main chain, which has improved thermal stability as well as dynamic property, and a process for the production of the polyester copolymer, at lower production cost. The polyester copolymer comprises an aromatic dicarboxylic acid, diol and at least one compound selected from aromatic compounds having amino group, represented by the following general formula (I),         H₂N - X - COOR   (I) wherein X is an aromatic ring-containing group and R is a hydrogen atom or a hydrocarbon group selected from alkyl groups and cycloalkyl groups.

  一种主链中含有芳香胺的聚酯共聚物，它具有更好的热稳定性和动态特性，以及一种生产成本更低的聚酯共聚物的生产工艺。该聚酯共聚物由芳香族二羧酸、二元醇和至少一种从具有氨基的芳香族化合物中选出的化合物组成，这些化合物由以下通式 (I) 表示、 h₂n - x - coor (i) 其中 X 是含芳香环的基团，R 是氢原子或选自烷基和环烷基的烃基。
• TREATING AGENT FOR LIQUID CRYSTAL ALIGNMENT LAYER AND LIQUID CRYSTAL DEVICE USING THE SAME, AND METHOD FOR ALIGNMENT OF LIQUID CRYSTAL
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP1111442A1

  公开（公告）日：2001-06-27

  Object Liquid crystal-alignment agent where uniform liquid alignment of liquid crystals is effectively manifested by the irradiation with light over the liquid crystal alignment film without rubbing treatment of the liquid crystal alignment film thereof, and further manifests liquid crystal alignment with high stability and high light resistance, liquid crystals device with the use of said alignment agent and the method of the liquid crystal alignment by the use of said liquid crystal alignment agent. Constitution Liquid crystal alignment agent where polymer compound having bonds shown in the general formula (1) - (7) below wherein R1, R2 and R3 are independently of each other hydrogen, alkyl, substituted alkyl, aryl or propargyl; in the polymer compound thereof with number-average molecular weight of 1,000 - 300,000, and said bond makes the direct bond with either divalent or trivalent aromatic group at the both ends of said bond or with divalent or trivalent aromatic group making the direct bond at one end while at the other forming the direct bond with divalent or trivalent alicyclic hydrocarbon group, liquid crystal device by the use of said liquid crystal alignment agent and the method of the liquid crystal alignment by the use of said liquid crystal alignment agent.

  目标 无需对液晶对位膜进行摩擦处理，通过对液晶对位膜进行光照射，即可有效实现液晶的均匀液态对位，并进一步实现高稳定性和高耐光性液晶对位的液晶对位剂、使用所述对位剂的液晶装置以及使用所述液晶对位剂的液晶对位方法。 构成 液晶配向剂，其中的聚合物化合物具有以下通式（1）-（7）所示的键 其中 R1、R2 和 R3 相互独立地为氢、烷基、取代烷基、芳基或丙基；在其平均分子量为 1,000 - 300,000 的聚合物化合物中，所述键在所述键的两端与二价或三价芳香族基团直接键合，或在一端与二价或三价芳香族基团直接键合，而在另一端与二价或三价脂环烃基团直接键合，通过使用所述液晶配向剂的液晶装置和通过使用所述液晶配向剂的液晶配向方法。
• QUANTUM NANOSTRUCTURES, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING SAME
  申请人：University of Rochester

  公开号：US20140170692A1

  公开（公告）日：2014-06-19

  Provided are methods for making quantum nanostructures based on use of a combination of nucleation and growth precursors. The methods can be used to provide quantum nanostructures of a selected size. Also provided are quantum nanostructures, compositions comprising the quantum nanostructures, and uses of the quantum nanostructures. The quantum nanostructures can be used, for example, in imaging applications.