3-[3,5-Ditert-butyl-4-(methoxymethoxy)phenyl]propan-1-ol | 188612-14-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[3,5-Ditert-butyl-4-(methoxymethoxy)phenyl]propan-1-ol
• CAS: 188612-14-8
• 化学式: C₁₉H₃₂O₃
• 分子量: 308.461
• InChiKey: SLZRMMBAAAAMPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-[3,5-Ditert-butyl-4-(methoxymethoxy)phenyl]propan-1-ol 在 sodium hydride 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 4-(3-(3-Benzenesulfonylfuroxan-4-yloxy)propyl)-2,6-di-tertbutylphenol
  参考文献：
  名称：

  Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants

  摘要：

  A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.10.006
• 作为产物：
  描述：

  3,5-二-叔丁基-4-(甲氧基甲氧基)苯甲醛 在 palladium on activated charcoal lithium aluminium tetrahydride 、 potassium tert-butylate 、 氢气 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成 3-[3,5-Ditert-butyl-4-(methoxymethoxy)phenyl]propan-1-ol
  参考文献：
  名称：

  Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants

  摘要：

  A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.10.006